Advertisement

Drugs

, Volume 11, Supplement 1, pp 121–126 | Cite as

Metabolic Effects ofβ-Adrenoreceptor Blockers

  • Hendrika J. Waal-Manning
Session V: Pharmacology of β-Adrenoreceptor Blocking Drugs Chairman: Professor M.J. Rand (Melbourne)

Summary

The effects of β-blockade on glucose metabolism are complex. Some patients with impaired glucose tolerance while taking a non-selectiveβ-blocker, showed some improvement in glucose tolerance when therapy was changed to a β1 -blocker (metoprolol). Serum K+ values tend to rise slightly on β-blocking therapy; small increases in serum urea and creatinine also occur. A rise in plasma triglycerides was noted in patients startingβ-blocking therapy; this effect seemed to be more marked on metoprolol than on non-selectiveβ-blockers.

Keywords

Propranolol Renin Metoprolol Plasma Renin Activity Pindolol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Carruthers, M.; Taggart, P. and Somerville, W.: Some effects of beta-blockade on the lipid response to certain emotions. Ciba Symposium ’New Perspectives in β-blockade’, Scanticon, Aarhus, Denmark (1972).Google Scholar
  2. Marian, M.; Loubatiéres, A.; Sore, L.G. et al.: Etude in vivo des activateurs ou bloqueues bêtaadrénergiques sur l’insulino-sécrétion. Différenciation pharmacologique du type de récepteur bêta implique. Diabetes 19: 129–133 (1971).Google Scholar
  3. Muir, G.G.; Chamberlain, D.A. and Pedoe, D.T.: Effects of β-sympathetic blockade on nonesterified fatty acid and carbohydrate metabolism at rest and during exercise. Lancet 2: 930–932 (1964).PubMedCrossRefGoogle Scholar
  4. Parving, H-H. and Gyntelburg, F.: Minimum transcapillary escape rate and plasma volume during longterm beta-adrenergic blockade in essential hypertension. Scandinavian Journal of Clinical and Laboratory Investigation 32: 105–110 (1973).PubMedCrossRefGoogle Scholar
  5. Tarazi, R.C.; Frohlich, E.D. and Dustan, H.P.: Plasma volume changes with long-term beta-adrenergic blockade. American Heart Journal 82: 770–776 (1971).PubMedCrossRefGoogle Scholar

Copyright information

© ADIS Press 1976

Authors and Affiliations

  • Hendrika J. Waal-Manning
    • 1
  1. 1.Wellcome Medical Research Institute, Department of MedicineUniversity of Otago Medical SchoolDunedinNew Zealand

Personalised recommendations