Drugs

, Volume 11, Supplement 1, pp 121–126 | Cite as

Metabolic Effects ofβ-Adrenoreceptor Blockers

  • Hendrika J. Waal-Manning
Session V: Pharmacology of β-Adrenoreceptor Blocking Drugs Chairman: Professor M.J. Rand (Melbourne)

Summary

The effects of β-blockade on glucose metabolism are complex. Some patients with impaired glucose tolerance while taking a non-selectiveβ-blocker, showed some improvement in glucose tolerance when therapy was changed to a β1 -blocker (metoprolol). Serum K+ values tend to rise slightly on β-blocking therapy; small increases in serum urea and creatinine also occur. A rise in plasma triglycerides was noted in patients startingβ-blocking therapy; this effect seemed to be more marked on metoprolol than on non-selectiveβ-blockers.

Keywords

Propranolol Renin Metoprolol Plasma Renin Activity Pindolol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Carruthers, M.; Taggart, P. and Somerville, W.: Some effects of beta-blockade on the lipid response to certain emotions. Ciba Symposium ’New Perspectives in β-blockade’, Scanticon, Aarhus, Denmark (1972).Google Scholar
  2. Marian, M.; Loubatiéres, A.; Sore, L.G. et al.: Etude in vivo des activateurs ou bloqueues bêtaadrénergiques sur l’insulino-sécrétion. Différenciation pharmacologique du type de récepteur bêta implique. Diabetes 19: 129–133 (1971).Google Scholar
  3. Muir, G.G.; Chamberlain, D.A. and Pedoe, D.T.: Effects of β-sympathetic blockade on nonesterified fatty acid and carbohydrate metabolism at rest and during exercise. Lancet 2: 930–932 (1964).PubMedCrossRefGoogle Scholar
  4. Parving, H-H. and Gyntelburg, F.: Minimum transcapillary escape rate and plasma volume during longterm beta-adrenergic blockade in essential hypertension. Scandinavian Journal of Clinical and Laboratory Investigation 32: 105–110 (1973).PubMedCrossRefGoogle Scholar
  5. Tarazi, R.C.; Frohlich, E.D. and Dustan, H.P.: Plasma volume changes with long-term beta-adrenergic blockade. American Heart Journal 82: 770–776 (1971).PubMedCrossRefGoogle Scholar

Copyright information

© ADIS Press 1976

Authors and Affiliations

  • Hendrika J. Waal-Manning
    • 1
  1. 1.Wellcome Medical Research Institute, Department of MedicineUniversity of Otago Medical SchoolDunedinNew Zealand

Personalised recommendations