Advertisement

Drugs

, Volume 2, Issue 5, pp 416–446 | Cite as

Ibuprofen: A Review of its Pharmacological Properties and Therapeutic Efficacy in Rheumatic Disorders

  • Elizabeth F. Davies
  • G. S. Avery
Evaluations on New Drugs

Synopsis

Ibuprofen, is a new non-steroidal agent advocated for the treatment of rheumatoid arthritis, osteo-arthrosis and allied rheumatic conditions.

Although ibuprofen has been shown to possess anti-inflammatory activity in certain tests in animals, this effect has not been striking in the therapeutic trials published to date. Its analgesic activity is less than that of aspirin when full dosages are compared, but occasional patients may prefer it to aspirin and other drugs because of fewer gastro-intestinal complaints.

Key Words

Analgesics Anti-inflammatory agents, non-steroidal Ibuprofen Arthritis, rheumatoid Osteo-arthrosis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams, S.S.; Bough, R.G.; Cliffe, E.E.; Dickinson, W.; Lessel, B.; McCullough, K.F.; Mills, R.F.N.; Nicholson, J.S., and Williams, G.A.H.: Some aspects of the pharmacology, metabolism and toxicology of ibuprofen. Rheumatology and Physical Medicine. Suppl. 9 (1970).Google Scholar
  2. Adams, S.S.; Bough, R.G.; Cliffe, E.E.; Lessel, B., and Mills, R.F.N.: Absorption, distribution and toxicity of ibuprofen. Toxicology and Applied Pharmacology 15: 310 (1969b).PubMedCrossRefGoogle Scholar
  3. Adams, S.S.; Cliffe, E.E.; Lessel, B., and Nicholson, J.S.: Some biological properties of 2-(4-isobutylphenyl) propionic acid. Journal of Pharmaceutical Sciences 56: 1686 (1967).PubMedCrossRefGoogle Scholar
  4. Adams, S.S.; McCullough, K.F., and Nicholson, J.S.: The pharmacological properties of ibuprofen, an anti-inflammatory, analgesic and antipyretic agent. Archives internationales de Pharmacodynamie et de Therapie 178: 115 (1969a).PubMedGoogle Scholar
  5. Baele, G.; De Weerdt, G.A., and Barbier, F.: Preliminary results of platelet aggregation before and after administration of ibuprofen. Rheumatology and Physical Medicine. Suppl. 108 (1970).Google Scholar
  6. Boardman, P.L.; Nuki, G., and Hart, F.D.: Ibuprofen in the treatment of rheumatoid arthritis and osteoarthritis. Annals of the Rheumatic Diseases 26: 560 (1967).PubMedCrossRefGoogle Scholar
  7. Bolosiu, H. and Ionescu, D.: Treatment with ibuprofen in rheumatology. Viata Medicala 18: 139 (1971).Google Scholar
  8. Brooks, C.D.; Schmid, F.R.; Biundo, J.; Blau, S.; Gonzalez-Alcover, R.; Gowans, J.D.C.; Hurd, E.; Partridge, R.E.H., and Tarpley, E.L.: Ibuprofen and aspirin in the treatment of rheumatoid arthritis: a co-operative double-blind trial. Rheumatology and Physical Medicine. Suppl. 48 (1970).Google Scholar
  9. Buckler, J.W. and Adams, S.S.: The phenylalkanoic acids. Laboratory and clinical studies. Medical Proceedings 14: 574 (1968).Google Scholar
  10. Cardoe, N.: Ibuprofen in the treatment of rheumatoid disease and osteo-arthritis of the hip. Paper read at the 12th International Congress of Rheumatology, Prague, October 1969.Google Scholar
  11. Cardoe, N.: A review of long-term experience with ibuprofen, with special reference to gastric tolerance. Rheumatology and Physical Medicine. Suppl. 28 (1970).Google Scholar
  12. Chalmers, T.M.: Clinical experience with ibuprofen in the treatment of rheumatoid arthritis. Annals of the Rheumatic Diseases 28: 513 (1969).PubMedCrossRefGoogle Scholar
  13. Chalmers, T.M.: Clinical experience with ibuprofen in rheumatoid arthritis. Schweizerische Medizinische Wochenschrift 101: 280 (1971).PubMedGoogle Scholar
  14. Collum, L.M.T. and Bowen, D.I.: Ocular side-effects of ibuprofen. British Journal of Ophthalmology 55: 472 (1971).PubMedCrossRefGoogle Scholar
  15. Cremoncini, C.: Clinical trials of ibuprofen in Milan. Rheumatology and Physical Medicine. Suppl. 64 (1970).Google Scholar
  16. Dick, W.C.; Nuki, G.; Whaley, K.; Deodhar, S., and Buchanan, W.W.: Some aspects in the quantitation of inflammation in joints of patients suffering from rheumatoid arthritis. Rheumatology and Physical Medicine. Suppl. 40 (1970).Google Scholar
  17. Dick-Smith, J.B.: Ibuprofen, aspirin and placebo in the treatment of rheumatoid arthritis. Medical Journal of Australia 2: 853(1969).PubMedGoogle Scholar
  18. Goldberg, A.A.J.; Hall, J.E.; Warwick Buckler, J.; Dodsworth, P.G., and Agar, J.: The long-term benefits of ibuprofen in rheumatological practice. Interim report. Practitioner 207: 343 (1971).PubMedGoogle Scholar
  19. Hingorani, K.: Double-blind cross-over trial comparing ibuprofen with flufenamic acid in rheumatoid arthritis. Rheumatology and Physical Medicine. Suppl. 76 (1970).Google Scholar
  20. Huskisson, E.C.; Shenfield, G.M.; Taylor, R.T., and Dudley Hart, F.: A new look at ibuprofen. Rheumatology and Physical Medicine. Suppl. 88 (1970).Google Scholar
  21. Jasani, M.K.; Wilson, Downie W.; Samuels, B.M., and Watson, Buchanan W.: Ibuprofen in rheumatoid arthritis. Clinical study of analgesic and anti-inflammatory activity. Annals of the Rheumatic Diseases 27: 457 (1968).PubMedCrossRefGoogle Scholar
  22. Lansbury, J.: in Hollander Arthritis and allied conditions (Lea and Febiger, Philadelphia 1966).Google Scholar
  23. Lessei, B.: In discussion, symposium on ibuprofen. Rheumatology and Physical Medicine. Suppl. 23 (1970).Google Scholar
  24. Lewis, D.A.: The actions of some non-steroidal drugs on lysosomes. Journal of Pharmacy and Pharmacology 22: 909 (1970).PubMedCrossRefGoogle Scholar
  25. Mills, R.F.N.: In discussion, symposium on ibuprofen. Rheumatology and Physical Medicine. Suppl. 25 (1970).Google Scholar
  26. Müller, K.H.: Ibuprofen in the treatment of degenerative and rheumatic joint conditions. Ärztliche Praxis 23: 1993 (1971).Google Scholar
  27. O’Brien, J.R.: Effect of anti-inflammatory agents on platelets. Lancet 1: 894 (1968).PubMedCrossRefGoogle Scholar
  28. Oreskovic, A. and Rill, M.: Supplement to the medicinal treatment of rheumatoid arthritis. Rheumatizm 17: 55 (1970).Google Scholar
  29. Owen-Smith, B.D. and Burry, H.C.: Ibuprofen in the management of osteo-arthrosis of the hip. Rheumatology and Physical Medicine. In press 1972.Google Scholar
  30. Sasaki, S.: Clinical trials of ibuprofen in Japan: Report from the Drug Evaluation Committee, the official organ of the Japan Rheumatism Association. Rheumatology and Physical Medicine. Suppl. 32 (1970).Google Scholar
  31. Thompson, M. and Anderson, Mary: Studies of gastrointestinal blood loss during ibuprofen therapy. Rheumatology and Physical Medicine. Suppl. 104 (1970).Google Scholar
  32. Thompson, M. and Bell, D.: Further experience with ibuprofen in the treatment of arthritis. Rheumatology and Physical Medicine. Suppl. 100 (1970).Google Scholar
  33. Thompson, M. and Fox, H.: Ibuprofen in the treatment of arthritis. Medical Proceedings 14: 579 (1968).Google Scholar
  34. Trnavsky, K. and Vrtkova, B.: Brufen (2,4′-isobutylphenylpropionic acid) in the treatment of rheumatoid arthritis. Fysiatricky vestnik 2: 89 (1971).Google Scholar
  35. Wallden, B. and Gyllenberg, B.: A comparative study of ibuprofen and calcium-acetylsalicylic acid in rheumatoid arthritis, with particular reference to biochemical parameters and side-effects. Rheumatology and Physical Medicine. Suppl. 83 (1970).Google Scholar
  36. Ward, T.: Purpura and ibuprofen. British Medical Journal 4: 430 (1969).PubMedCrossRefGoogle Scholar

Copyright information

© Adis International Limited 1971

Authors and Affiliations

  • Elizabeth F. Davies
    • 1
  • G. S. Avery
    • 1
  1. 1.Australasian Drug Information ServicesTakapuna NorthNew Zealand

Personalised recommendations