Abstract
More than 20 individual and fixed-dose combinations of antiretrovirals are approved for the treatment of human immunodeficiency virus (HIV) infection. However, owing to the ongoing limitations of drug resistance and adverse effects, new treatment options are still required. A number of promising new agents in existing or new drug classes are in development or have recently been approved by the US FDA. Since these agents will be used in combination with other new and existing antiretrovirals, understanding the potential for drug interactions between these compounds is critical to their appropriate use. This article summarizes the drug interaction potential of new and investigational protease inhibitors (darunavir), non-nucleoside reverse transcriptase inhibitors (etravirine and rilpivirine), chemokine receptor antagonists (maraviroc, vicriviroc and INCB 9471), integrase inhibitors (raltegravir and elvitegravir) and maturation inhibitors (bevirimat).
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Acknowledgements
This work was supported by Boehringer Ingelheim Pharmaceuticals, Inc. Dr Kashuba has received honoraria from Boehringer Ingelheim Pharmaceuticals, Inc. and Tibotec Pharmaceuticals, and grants from Merck, Pfizer, Tibotec, Abbott and Gilead. The other authors have no conflicts of interest that are directly relevant to the content of this review.
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Brown, K.C., Paul, S. & Kashuba, A.D.M. Drug Interactions with New and Investigational Antiretrovirals. Clin Pharmacokinet 48, 211–241 (2009). https://doi.org/10.2165/00003088-200948040-00001
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DOI: https://doi.org/10.2165/00003088-200948040-00001