Clinical Pharmacokinetics

, Volume 41, Issue 1, pp 1–6 | Cite as

Using Pharmacokinetic-Pharmacodynamic Relationships to Predict the Effect of Poor Compliance

  • Jean-Pierre Boissel
  • Patrice Nony
Leading Article


Since it is difficult to improve patient compliance to drug prescriptions, an alternative is to select a drug with less consequences for poor compliance, that is, a drug that has the capacity of ‘forgiveness’. Forgiveness is the property of a drug which, when compared with another medicine with different pharmacokinetics and/or concentration-effect relationships, blunts the consequences of missing one or two doses in a row, or has a greater variability in the timing of intake. Simulations show that drugs with a concentration-effect relationship modelled with an effect compartment, for example a delayed response, have more forgiveness. A marker of forgiveness would be of some help for doctors deciding which drug to prescribe to patients who are poor compilers.


Poor Compliance Peripheral Compartment Effect Compartment Improve Patient Compliance Drug Holiday 
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This work was supported by APRET (Agence Pour la Recherche et l’Evaluation Thérapeutique), the Luennec Medical School and Lyon Teaching Hospital.


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Copyright information

© Adis International Limited 2002

Authors and Affiliations

  1. 1.Department of Clinical PharmacologyClaude Bernard University and Teaching HospitalLyonFrance

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