Clinical Pharmacokinetics

, Volume 30, Issue 4, pp 314–327 | Cite as

Pharmacokinetic Individualisation of Zidovudine Therapy

Current State of Pharmacokinetic-Pharmacodynamic Relationships
  • Richard M. W. Hoetelmans
  • David M. Burger
  • Pieter L. Meenhorst
  • Jos H. Beijnen
Review Article Pharmacokinetic-Pharmacodynamic Relationships

Summary

Zidovudine is the cornerstone of current antiretroviral treatment of human immunodeficiency virus (HIV) infection. Its use, however, frequently leads to adverse reactions, including myelosuppression. Zidovudine pharmacokinetic s show large interindividual variation with indications of pharmacokinetic-pharmacodynamic relationships, but a clear therapeutic window has not yet been defined. Individualisation of zidovudine therapy with monitoring of drug concentrations might be desirable. This review considers (intracellular) monitoring of zidovudine and anabolites for individualisation of zidovudine therapy and the achievements in describing pharmacokinetic-pharmacodynamic relationships so far.

Keywords

Human Immunodeficiency Virus Zidovudine Antimicrob Agent Zidovudine Therapy Large Interindividual Variation 

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Copyright information

© Adis International Limited 1996

Authors and Affiliations

  • Richard M. W. Hoetelmans
    • 1
  • David M. Burger
    • 2
  • Pieter L. Meenhorst
    • 3
  • Jos H. Beijnen
    • 1
  1. 1.Department of PharmacySlotervaart HospitalAmsterdamThe Netherlands
  2. 2.Department of Clinical PharmacyUniversity Hospital NijmegenNijmegenThe Netherlands
  3. 3.Department of Internal MedicineSlotervaart HospitalAmsterdamThe Netherlands

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