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Clinical Pharmacokinetics

, Volume 29, Issue 1, pp 1–5 | Cite as

Novel Delivery of Antiarrhythmic Agents

  • Vinod Labhasetwar
  • Robert J. Levy
Leading Article

Summary

Conventional antiarrhythmia therapy by oral or intravenous routes of administration is often ineffective and results in drug-associated complications and toxicity. In addition, poor bioavailability and a high first-pass effect limit therapeutic applications of several investigational antiarrhythmic compounds, which are otherwise more potent and less toxic than available agents. The regional nature of the several cardiac diseases, such as ischaemia, restenosis or heart valve calcification, may require a high concentration of drug at the location of the disease, which by conventional routes may not be attainable due to systemic toxicity of the drug.

Localised cardiac delivery of antiarrhythmic agents, based on drug-polymer implants, may have several advantages, including enhanced drug effects and reduced systemic drug toxicity. Computer-assisted automated feedback systems may further enhance the usefulness of this therapy in the clinical setting.

Before clinical application of this method of drug delivery further study will be required, but it is hypothesised that pharmacokinetic variability for drugs delivered in this manner will be reduced and therefore efficacy and toxicity will be more predictable.

Keywords

Sotalol Antiarrhythmic Agent Dofetilide Ibutilide Amidon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis International Limited 1995

Authors and Affiliations

  • Vinod Labhasetwar
    • 1
  • Robert J. Levy
    • 1
  1. 1.Division of Pediatrie CardiologyUniversity of Michigan Medical CenterAnn ArborUSA

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