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Pharmacokinetics and Therapeutic Efficacy of Retinoids in Skin Diseases

  • Review Article
  • Pharmacokinetics — Therapeutics
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Summary

The retinoids are a class of compounds that includes the natural forms and synthetic analogues of vitamin A. Isotretinoin, often referred to as a first generation retinoid, may be of considerable benefit to patients with severe, recalcitrant acne. Etretinate and acitretin, 2 aromatic compounds representing the second generation, have found their major success in the treatment of psoriasis, particularly in combination with more traditional therapies. Retinoid therapy is associated with a distinctive adverse effect profile typical of hypervitaminosis A; thus, it is especially important that fertile women undergoing retinoid therapy adhere to a contraceptive regimen. These drugs are extensively metabolised and only traces of unchanged drugs are eliminated in urine. The terminal elimination half-lives of isotretinoin, etretinate and acitretin after long term treatment are up to 20h, 120 days and 48h, respectively. Because of lack of definite correlation between plasma concentration and desired pharmacological effects, in conjunction with the very pronounced inter- and intraindividual variation in systemic availability (15 to 90%) after oral administration of these drugs, initial dosages in individual patients can only be roughly judged on the basis of the general pharmacokinetics of the agents. Later dosage adjustments should be made on the basis of monitoring of both plasma drug (and possible metabolite) concentrations, and the efficacy and tolerability of the drugs.

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References

  • Berbis P, Bun H, Al Mallah NR, Durand A, Rognin C, et al. Residual plasma concentrations of acitretin (Ro 10-1670) and its metabolite (Ro 13-7652) after chronic administration. Dermatologica 177: 244–246, 1988a

    Article  PubMed  CAS  Google Scholar 

  • Berbis P, Bun H, Geiger JM, Rognin C, Durand A, et al. Acitretin (Ro 10-1670) and oral contraceptives: interaction study. Archives of Dermatological Research 280: 388–389, 1988b

    Article  PubMed  CAS  Google Scholar 

  • Berbis P, Geiger J-M, Vaisse C, Rognin C, Privat Y. Benefit of progressively increasing doses during the initial treatment with acitretin in psoriasis. Dermatologica 178: 88–92, 1989

    Article  PubMed  CAS  Google Scholar 

  • Bollag W. Therapeutic effects of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinoma of mice. European Journal of Cancer 10: 731–737, 1974

    Article  PubMed  CAS  Google Scholar 

  • Bollag W. The development of retinoids in experimental and clinical oncology and dermatology. Journal of the American Academy of Dermatology 9: 797–805, 1983

    Article  PubMed  CAS  Google Scholar 

  • Bollag W, Geiger J-M. The development of retinoids in dermatology. In Cunliffe & Miller (Eds) Retinoid therapy: a review of clinical and laboratory research. Proceedings of an international conference (London), pp. 1–7, MTP Press Limited, 1984

    Google Scholar 

  • Bouclier M, Shroot B, Eustache J, Hensby CN. A rapid and simple test system for the evaluation of the inhibitory activity in the hairless rat epidermis. Journal of Pharmacological Methods 16: 151–160, 1986

    Article  PubMed  CAS  Google Scholar 

  • Brazzell RK, Colburn WA. Pharmacokinetics of the retinoids isotretinoin and etretinate: a comparative review. Journal of the American Academy of Dermatology 6: 642–651, 1982

    Article  Google Scholar 

  • Brazzell RK, Vane FM, Ehmann CW, Colburn WA. Pharmacokinetics of isotretinoin during repetitive dosing to patients. European Journal of Clinical Pharmacology 24: 695–702, 1983

    Article  PubMed  CAS  Google Scholar 

  • Brindley CJ. Overview of recent clinical pharmacokinetic studies with acitretin (Ro 10-1670, Etretin). Dermatologica 178: 79–87, 1989

    Article  PubMed  CAS  Google Scholar 

  • Brion DE, Raynaud F, Plet A, Laurent P, Leduc B. Effect of retinoids on cAMP-mediated events in human psoriatic fibroblasts. In Saurat (Ed.) Retinoids: new trends in research and therapy. Retinoid Symposium, Geneva, pp. 189–193, Karger, Basel, 1985

    Google Scholar 

  • Camisa C, Eisenstat B, Ragaz A, Weissmann G. The effect of retinoids on neutrophil functions in vitro. Journal of the American Academy of Dermatology 6: 620–629, 1982

    Article  PubMed  CAS  Google Scholar 

  • Colburn WA, Gibson DM, Wiens RE, Hanigan JJ. Food increases the bioavailability of isotretinoin. Journal of Clinical Pharmacology 23: 534–539, 1983b

    PubMed  CAS  Google Scholar 

  • Colburn WA, Vane FM, Shorter HJ. Pharmacokinetics of isotretinoin and its major blood metabolite following a single oral dose to man. European Journal of Clinical Pharmacology 24: 689–694, 1983a

    Article  PubMed  CAS  Google Scholar 

  • Cotter S, Bugge CJL, Colburn WA. Role of gut contents, intestinal wall, and liver on the first pass metabolism and absolute bioavailability of isotretinoin in the dog. Drug Metabolism and Disposition 2: 458–462, 1983

    Google Scholar 

  • Cunliffe WJ, Norris JFB. Isotretinoin: an explanation for its long-term benefit. Dermatologica 175 (Suppl. 1): 133–137, 1987

    Article  PubMed  Google Scholar 

  • DiGiovanna JJ, Gross EG, McClean SW, Ruddel ME, Gantt G, et al. Etretinate: effect of milk intake on absorption. Journal of Investigative Dermatology 82: 636–640, 1984

    Article  PubMed  CAS  Google Scholar 

  • DiGiovanna JJ, Helfgott RK, Gerber LH, Peck GL. Extraspinal tendon and ligament calcification associated with long-term therapy with etretinate. New England Journal of Medicine 315: 1177–1182, 1986

    Article  PubMed  CAS  Google Scholar 

  • DiGiovanna JJ, Zech LA, Ruddel ME, Gantt G, Peck GL. Etretinate: persistent serum levels after long-term therapy. Archives of Dermatology 125: 246–251, 1989

    Article  PubMed  CAS  Google Scholar 

  • Dubertret L, Lebreton C, Touraine R. Inhibition of neutrophil migration by etretinate and its main metabolite. British Journal of Dermatology 107: 681–685, 1982

    Article  PubMed  CAS  Google Scholar 

  • Dubertret L, Touraine R. The role of neutrophil leukocytes in the psoriatic epidermal process: preliminary results. In Farber & Cox (Eds) Psoriasis: proceedings of the second international symposium, pp. 371–374, Yorke Medical Books, New York, 1976

    Google Scholar 

  • Ellis CN, Voorhees JJ. Etretinate therapy. Journal of the American Academy of Dermatology 16: 267–291, 1987

    Article  PubMed  CAS  Google Scholar 

  • Farrell L, Strauss JS, Stranieri AM. The treatment of severe cystic acne with 13-cis-retinoic acid. Journal of the American Academy of Dermatology 3: 602–611, 1980

    Article  PubMed  CAS  Google Scholar 

  • Fraunfelder FT, LaBraico JM, Meyer SM. Adverse ocular reactions possibly associated with isotretinoin. American Journal of Ophthalmology 100: 534–537, 1985

    PubMed  CAS  Google Scholar 

  • Giguere V, Ong ES, Segui P, Evans RM. Identification of a receptor for the morphogen retinoic acid. Nature 330: 624–629, 1987

    Article  PubMed  CAS  Google Scholar 

  • Goldfarb MT, Ellis CN, Voorhees JJ. Short-term and long-term considerations in the management of psoriasis with retinoids. Dermatologica 175 (Suppl. 1): 100–106, 1987

    Article  PubMed  Google Scholar 

  • Goldstein JA, Comite H, Mescon H, Pochi PE. Isotretinoin in the treatment of acne: histologic changes, sebum production and clinical observations. Archives of Dermatology 118: 555–558, 1982a

    Article  PubMed  CAS  Google Scholar 

  • Goldstein JA, Socha-Szott A, Thomsen RJ, Pochi PE, Shalita AR, et al. Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion. Journal of the American Academy of Dermatology 6: 760–765, 1982b

    Article  PubMed  CAS  Google Scholar 

  • Gollnick H, Bauer R, Brindley C, Orfanos CE, Plewig G, et al. Acitretin versus etretinate in psoriasis. Journal of the American Academy of Dermatology 19: 458–469, 1988

    Article  PubMed  CAS  Google Scholar 

  • Goodman GE, Einspahr JG, Alberts DS, Davis TP, Leigh SA, et al. Pharmacokinetics of 13-cis-retinoic acid in patients with advanced cancer. Cancer Research 42: 2087–2091, 1982

    PubMed  CAS  Google Scholar 

  • Grekin RC, Ellis CN, Goldstein NG, Swanson NA, Anderson TF, et al. Decreased urinary polyamines in patients with psoriasis treated with etretinate. Journal of Investigative Dermatology 80: 181–184, 1983

    Article  PubMed  CAS  Google Scholar 

  • Gupta AK, Goldfarb MT, Ellis CN, Voorhees JJ. Side-effect profile of acitretin therapy in psoriasis. Journal of the American Academy of Dermatology 20: 1088–1093, 1989

    Article  PubMed  CAS  Google Scholar 

  • Hanni R. Pharmacokinetic and metabolic pathways of systemically applied retinoids. Dermatologica 157 (Suppl. 1): 5–10, 1978

    Article  PubMed  Google Scholar 

  • Happle R, Traupe H, Bounameaux Y, Fisch T. Teratogene Wirkung von Etretinat beim Menschen. Deutsche Medizinische Wochenschrift 109: 1476–1480, 1984

    Article  PubMed  CAS  Google Scholar 

  • Harms M. Systemic isotretinoin (‘Roaccutan’): a unique therapeutic effect and its implications in the pathogenesis of acne. Editions Roche, Basel, 1989

    Google Scholar 

  • Harms M, Masouye I, Radeff B. The relapses of cystic acne after isotretinoin treatment are age-related: a long-term follow-up study. Dermatologica 172: 148–153, 1986

    Article  PubMed  CAS  Google Scholar 

  • Holian O, Kumar R. Cyclic AMP and cyclic AMP-dependent protein kinase in mouse skin II: in vitro effects of isotretinoin and etretinate. Archives of Dermatological Research 278: 161–164, 1985

    Article  PubMed  CAS  Google Scholar 

  • Keddie F. Use of vitamin A in the treatment of cutaneous diseases: relation to estrogen and vitamin B complex. Archives of Dermatology and Syphilology 58: 64–73, 1948

    Article  PubMed  CAS  Google Scholar 

  • Kemper C, Holland ML, Thorne EG, Anders J, Wills RJ. Percutaneous absorption of 3H-tretinoin following long-term administration of topical tretinoin. Abstract. Dermatologica 181: 351, 1990

    Google Scholar 

  • Khoo KC, Reik D, Colburn WA. Pharmacokinetics of isotretinoin following a single oral dose. Journal of Clinical Pharmacology 22: 395–402, 1982

    Article  PubMed  CAS  Google Scholar 

  • Kilcoyne RF. Effects of retinoids in bone. Journal of the American Academy of Dermatology 19: 212–216, 1988

    Article  PubMed  CAS  Google Scholar 

  • King K, Jones DH, Daltrey DC, Cunliffe WJ. A double-blind study of the effects of 13-cis-retinoic acid on acne, sebum excretion rate and microbial population. British Journal of Dermatology 107: 583–590, 1982

    Article  PubMed  CAS  Google Scholar 

  • Kingston TP, Matt LH, Lowe NJ. Etretin therapy for severe psoriasis. Archives of Dermatology 123: 55–58, 1987

    Article  PubMed  CAS  Google Scholar 

  • Kochhar DM, Penner JD, Minutella LM. Biotransformation of etretinate and developmental toxicity of etretin and other aromatic retinoids in teratogenesis bioassays. Drug Metabolism and Disposition 17: 618–624, 1989

    PubMed  CAS  Google Scholar 

  • Korner WF, Vollum J. New aspects of the tolerance of retinol in humans. International Journal of Vitamins and Nutritional Research 45: 363–372, 1975

    CAS  Google Scholar 

  • Kragballe K, Jansen CT, Geiger J-M, Bjerke JR, Falk ES, et al. A double-blind comparison of acitretin and etretinate in the treatment of severe psoriasis. Acta Dermato-Venereologica 69: 35–40, 1989

    PubMed  CAS  Google Scholar 

  • Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, et al. Retinoic acid embryopathy. New England Journal of Medicine 313: 837–841, 1985

    Article  PubMed  CAS  Google Scholar 

  • Landthaler M, Kummermehr J, Wagner A, Plewig G. Inhibitory effects of 13-cis-retinoic acid on human sebaceous glands. Archives of Dermatological Research 269: 297–309, 1980

    Article  PubMed  CAS  Google Scholar 

  • Larsen FG, Jakobsen P, Eriksen H, Grønhøj J, Kragballe K, et al. The pharmacokinetics of acitretin and its 13-cis-metabolite in psoriatic patients. Journal of Clinical Pharmacology 31: 477–483, 1991

    PubMed  CAS  Google Scholar 

  • Larsen FG, Jakobsen P, Larsen CG, Kragballe K, Nielsen-Kudsk F. Pharmacokinetics of etretin and etretinate during long-term treatment of psoriasis patients. Pharmacology and Toxicology 62: 159–165, 1988

    Article  PubMed  CAS  Google Scholar 

  • Larsen FG, Jakobsen P, Larsen CG, Nørgaard A, Kragballe K, et al. Single dose pharmacokinetics of etretin and etretinate in psoriatic patients. Pharmacology and Toxicology 61: 85–88, 1987

    Article  PubMed  CAS  Google Scholar 

  • Larsen FG, Nielsen-Kudsk F, Jakobsen P, Kragballe K. Pharmacokinetics of etretinate in psoriatic patients with liver fibrosis. Pharmacology and Toxicology 65: 393–397, 1989

    Article  PubMed  CAS  Google Scholar 

  • Larsen FG, Nielsen-Kudsk F, Jakobsen P, Schrøder H, Kragballe K. Interaction of etretinate with methotrexate pharmacokinetics in psoriatic patients. Journal of Clinical Pharmacology 30: 802–807, 1990

    PubMed  CAS  Google Scholar 

  • Lebowitz MA, Berson DS. Ocular effects of oral retinoids. Journal of the American Academy of Dermatology 19: 209–211, 1988

    Article  PubMed  CAS  Google Scholar 

  • Leyden JJ, McGinley KJ, Foglia AN. Qualitative and quantitative changes in cutaneous bacteria associated with systemic isotretinoin therapy for acne conglobata. Journal of Investigative Dermatology 86: 390–393, 1986

    Article  PubMed  CAS  Google Scholar 

  • Lowe NJ, Kaplan R, Breeding J. Etretinate treatment for psoriasis inhibits epidermal ornithine decarboxylase. Journal of the American Academy of Dermatology 6: 697–698, 1982

    Article  PubMed  CAS  Google Scholar 

  • Marsden JR. Lipid metabolism and retinoid therapy. Pharmacology and Therapeutics 40: 55–65, 1989

    Article  PubMed  CAS  Google Scholar 

  • Massarella J, Vane F, Bugge C, Rodriguez L, Cunningham WJ, et al. Etretinate kinetics during chronic dosing in severe psoriasis. Clinical Pharmacology and Therapeutics 37: 439–446, 1985

    Article  PubMed  CAS  Google Scholar 

  • Matt L, Lazarus N, Lowe NJ. Newer retinoids for psoriasis: early clinical studies. Pharmacology and Therapeutics 40: 157–169, 1989

    Article  PubMed  CAS  Google Scholar 

  • McNamara PJ, Jewell RC, Jensen BK, Brindley CJ. Food increases the bioavailability of acitretin. Journal of Clinical Pharmacology 28: 1051–1055, 1988

    PubMed  CAS  Google Scholar 

  • Meigel W, Gollnick H, Wokalek H, Plewig G. Orale Behandlung der Acne conglobata mit 13-cis-Retinsaure. Der Hautarzt 34: 387–397, 1983

    CAS  Google Scholar 

  • Norris DA, Osborn R, Robinson W, Tonnesen MG. Isotretinoin produces significant inhibition of monocyte and neutrophil chemotaxis in vivo in patients with cystic acne. Journal of Investigative Dermatology 89: 38–43, 1987

    Article  PubMed  CAS  Google Scholar 

  • Orfanos CE, Ehlert R, Gollnick H. The retinoids: a review of their clinical pharmacology and therapeutic use. Drugs 34: 459–503, 1987

    Article  PubMed  CAS  Google Scholar 

  • Orfanos CE, Mahrle G, Goerz G, Happle R, Hofbauer M, et al. Laboratory investigations in patients with generalized psoriasis under oral retinoid treatment. Dermatologica 159: 62–70, 1979

    Article  PubMed  CAS  Google Scholar 

  • Paravicini U. Pharmacokinetics and metabolism of oral aromatic retinoids. In Orfanos et al. (Eds) Retinoids: advances in basic research and therapy, pp. 13–20, Springer-Verlag, Berlin, 1981

    Google Scholar 

  • Paravicini U, Camenzind M, Gower M, Geiger JM, Saurat JH. Multiple dose pharmacokinetics of Ro 10-1670, the main metabolite of etretinate (Tigason). In Saurat (Ed.) Retinoids: new trends in research and therapy, pp. 289–292, Karger, Basel, 1985

    Google Scholar 

  • Paravicini U, Stockel K, MacNamara PJ, Hanni R, Busslinger A. On metabolism and pharmacokinetics of an aromatic retinoid. Annals of the New York Academy of Sciences 359: 54–67, 1981

    Article  PubMed  CAS  Google Scholar 

  • Peck GL. Retinoids: therapeutic use in dermatology. Drugs 24: 341–351, 1982

    Article  PubMed  CAS  Google Scholar 

  • Peck GL, Olsen TG, Butkus D, Pandya M, Arnaud-Battandier J, et al. Isotretinoin versus placebo in the treatment of cystic acne. Journal of the American Academy of Dermatology 6: 735–745, 1982

    Article  PubMed  CAS  Google Scholar 

  • Peck GL, Olsen TG, Yoder FW. Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid. New England Journal of Medicine 300: 329–333, 1979

    Article  PubMed  CAS  Google Scholar 

  • Petkovich M, Brand NJ, Krust A, Chambon P. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330: 444–450, 1987

    Article  PubMed  CAS  Google Scholar 

  • Pittsley RA, Yoder FW. Retinoid hyperostosis: skeletal toxicity associated with long-term administration of 13-cis-retinoic acid for refractory ichthyosis. New England Journal of Medicine 308: 1012–1014, 1983

    Article  PubMed  CAS  Google Scholar 

  • Rasmussen H, Goodman D. Relationship between calcium and cyclic nucleotides in cell activation. Physiological Reviews 57: 421–509, 1977

    PubMed  CAS  Google Scholar 

  • Ray S, Begg E, Wade D. Pharmacokinetics of an aromatic retinoid, RO 10-9359, and its metabolites RO 10-1670 and RO 13-7652 in patients with Darier’s disease. Clinical and Experimental Pharmacology and Physiology 8: 674, 1981

    Google Scholar 

  • Raynaud F, Leduc C, Anderson WB, Evain-Brion D. Retinoid treatment of human psoriatic fibroblasts induces an increase in cyclic AMP-dependent protein kinase activity. Journal of Investigative Dermatology 89: 105–110, 1987

    Article  PubMed  CAS  Google Scholar 

  • Roenigk HH, Gibstine C, Glazer S, Sparberg M, Yokoo H. Serial liver biopsies in psoriatic patients receiving long-term etretinate. British Journal of Dermatology 112: 77–81, 1985

    Article  PubMed  Google Scholar 

  • Rollman O, Pihl-Lundin I. Acitretin excretion into human breast milk. Acta Dermato-Venereologica 70: 487–490, 1990

    PubMed  CAS  Google Scholar 

  • Rollman O, Vahlquist A. Retinoid concentrations in skin, serum and adipose tissue of patients treated with etretinate. British Journal of Dermatology 109: 439–447, 1983

    Article  PubMed  CAS  Google Scholar 

  • Rollman O, Vahlquist A. Oral isotretinoin (13-cis-retinoic acid) therapy in severe acne: drug and vitamin A concentrations in serum and skin. Journal of Investigative Dermatology 86: 384–389, 1986

    Article  PubMed  CAS  Google Scholar 

  • Saurat J-H, Hirschel-Scholz S, Salomon D, Siegenthaler G. Human skin retinoid-binding proteins and therapy with synthetic retinoids: a still unexplained link. Dermatologica 175 (Suppl. 1): 13–19, 1987

    Article  PubMed  Google Scholar 

  • Shalita AR. Mucocutaneous and systemic toxicity of retinoids: monitoring and management. Dermatologica 175 (Suppl. 1): 151–157, 1987

    Article  PubMed  Google Scholar 

  • Shalita AR. Lipid and teratogenic effects of retinoids. Journal of the American Academy of Dermatology 19: 197–198, 1988

    Article  PubMed  CAS  Google Scholar 

  • Shalita AR, Armstrong RB, Leyden JJ, Pochi PE, Strauss JS. Isotretinoin revisited. Cutis 42: 1–19, 1988

    PubMed  CAS  Google Scholar 

  • Siegenthaler G, Saurat J-H. Retinoid binding proteins and human skin. Pharmacology and Therapeutics 40: 45–54, 1989

    Article  PubMed  CAS  Google Scholar 

  • Sporn MB, Roberts AB. What is a retinoid? In Retinoids, differentiation and disease. Ciba Foundation Symposium, No. 113, pp. 1–5, Pitman, London, 1985

    Google Scholar 

  • Stewart ME, Benoit AM, Stranieri AM, Rapini RP, Strauss JS, et al. Effect of oral 13-cis-retinoic acid at three dose levels on sustainable rates of sebum secretion and on acne. Journal of the American Academy of Dermatology 8: 532–538, 1983

    Article  PubMed  CAS  Google Scholar 

  • Strauss JS, Rapini RP, Shalita AR, Konecky E, Pochi PE, et al. Isotretinoin therapy of acne: results of a multicenter dose-response study. Journal of the American Academy of Dermatology 10: 490–496, 1984

    Article  PubMed  CAS  Google Scholar 

  • Strauss JS, Stranieri AM. Changes in long-term sebum production from isotretinoin therapy. Journal of the American Academy of Dermatology 6: 751–755, 1982

    Article  PubMed  CAS  Google Scholar 

  • Stuck AE, Brindley CJ, Busslinger A, Frey FJ. Pharmacokinetics of acitretin and its 13-cis metabolite in patients on haemodialysis. British Journal of Clinical Pharmacology 27: 301–304, 1989

    Article  PubMed  CAS  Google Scholar 

  • Taieb A, Maleville J. Retinoid dermatitis mimicking ‘eczema craquele’. Acta Dermato-Venereologica 65: 570, 1985

    PubMed  CAS  Google Scholar 

  • Tfelt-Hansen P, Knudsen B, Petersen E, Sørensen EB. Spinal cord compression after long-term etretinate. Lancet 2: 325–326, 1989

    Article  PubMed  CAS  Google Scholar 

  • Tsambaos D, Orfanos CE. Effects of oral retinoid on dermal components in human and animal skin. In Orfanos et al. (Eds) Retinoids: advances in basic research and therapy, pp. 99–108, Springer-Verlag, Berlin, 1981

    Google Scholar 

  • Vahlquist A. Etretinate pharmacokinetics in chronic renal failure. Dermatologica 175: 224–228, 1987

    Article  PubMed  CAS  Google Scholar 

  • Vahlquist A, Michaelsson G, Kober A, Sjoholm I, Palmskog G, et al. In Orfanos et al. (Eds) Retinoids: advances in basic research and therapy, pp 109–116, Springer-Verlag, Berlin, 1981

  • Vahlquist C, Michaelsson G, Vahlquist A, Vessby B. A sequential comparison of etretinate (Tigason) and isotretinoin (Roaccutane) with special regard to their effects on serum lipoproteins. British Journal of Dermatology 112: 69–76, 1985

    Article  PubMed  CAS  Google Scholar 

  • Vahlquist C, Selinus I, Vessby B. Serum lipid changes during acitretin (etretin) treatment of psoriasis and palmoplantar pustulosis. Acta Dermato-Venereologica 68: 300–305, 1988

    PubMed  CAS  Google Scholar 

  • van Ditzhuijsen TJ, van Haelst UJ, van Dooren Greebe, van de Kerkhof PC, Yap SH. Severe hepatotoxic reaction with progression to cirrhosis after use of a novel retinoid (acitretin). Journal of Hepatology 11: 185–188, 1990

    Article  PubMed  Google Scholar 

  • Weiss VC, Layden T, Spinowitz A, Buys M, Nemchausky BA, et al. Chronic active hepatitis associated with etretinate therapy. British Journal of Dermatology 112: 591–597, 1985

    Article  PubMed  CAS  Google Scholar 

  • Wolska H, Jablonska S, Bounameaux Y. Etretinate in severe psoriasis. Journal of the American Academy of Dermatology 9: 883–889, 1983

    Article  PubMed  CAS  Google Scholar 

  • Zachariae H, Foged E, Bjerring P, Kragballe K, Søgaard H. Liver biopsy during etretinate (Tigason) treatment. In Saurat (Ed.) Retinoids: new trends in research and therapy, pp. 494–497, Karger, Basel, 1985

    Google Scholar 

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  1. Department of Dermatology, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400, Copenhagen NV, Denmark

    Frederik Grønhøj Larsen, Folmer Nielsen-Kudsk, Preben Jakobsen, Kaare Weismann & Knud Kragballe

  2. Institute of Pharmacology, University of Aarhus, Denmark

    Frederik Grønhøj Larsen, Folmer Nielsen-Kudsk, Preben Jakobsen, Kaare Weismann & Knud Kragballe

  3. Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark

    Frederik Grønhøj Larsen, Folmer Nielsen-Kudsk, Preben Jakobsen, Kaare Weismann & Knud Kragballe

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Larsen, F.G., Nielsen-Kudsk, F., Jakobsen, P. et al. Pharmacokinetics and Therapeutic Efficacy of Retinoids in Skin Diseases. Clin. Pharmacokinet. 23, 42–61 (1992). https://doi.org/10.2165/00003088-199223010-00004

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