The Relative Bioavailability of Temafloxacin Administered through a Nasogastric Tube With and Without Enterai Feeding
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The relative bioavailability of a single oral dose of temafloxacin given with and without enterai feeding was determined in 18 healthy male volunteers in a randomised crossover study. Subjects were administered 600mg of temafloxacin orally as an intact tablet, or a crushed tablet suspended in water administered through a nasogastric tube with or without an enterai feeding solution [Osmolite® (Ross) 100 ml/h started 2h before administration of temafloxacin and continued for 4h postdose]. Plasma samples were analysed by a high performance liquid Chromatographic technique. Mean peak plasma concentrations (Cmax) for the oral tablet, crushed tablet, and crushed tablet with enterai feeding solution were 3.95 ± 1.02, 4.85 ± 0.69, and 4.69 ± 0.61 mg/L/70kg, respectively, and mean calculated area under the concentration-time curve from time 0 to 48h (AUC(0–48h)) values were 48.1 ± 11.0,54.5 ± 6.52, and 49.7 ± 5.89 mg/L · h/70kg, respectively. In terms of AUC(0–48h) and Cmax, the relative bioavailability of temafloxacin after nasogastric delivery of crushed temafloxacin given with and without an enterai feeding solution was equivalent to the reference oral regimen.
KeywordsEnteral Feeding Pefloxacin Enoxacin Relative Bioavailability Fleroxacin
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