The Relative Bioavailability of Temafloxacin Administered through a Nasogastric Tube With and Without Enterai Feeding

Summary

The relative bioavailability of a single oral dose of temafloxacin given with and without enterai feeding was determined in 18 healthy male volunteers in a randomised crossover study. Subjects were administered 600mg of temafloxacin orally as an intact tablet, or a crushed tablet suspended in water administered through a nasogastric tube with or without an enterai feeding solution [Osmolite® (Ross) 100 ml/h started 2h before administration of temafloxacin and continued for 4h postdose]. Plasma samples were analysed by a high performance liquid Chromatographic technique. Mean peak plasma concentrations (C_max) for the oral tablet, crushed tablet, and crushed tablet with enterai feeding solution were 3.95 ± 1.02, 4.85 ± 0.69, and 4.69 ± 0.61 mg/L/70kg, respectively, and mean calculated area under the concentration-time curve from time 0 to 48h (AUC_(0–48h)) values were 48.1 ± 11.0,54.5 ± 6.52, and 49.7 ± 5.89 mg/L · h/70kg, respectively. In terms of AUC_(0–48h) and C_max, the relative bioavailability of temafloxacin after nasogastric delivery of crushed temafloxacin given with and without an enterai feeding solution was equivalent to the reference oral regimen.