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Clinical Pharmacokinetics

, Volume 21, Issue 4, pp 285–307 | Cite as

Pharmacokinetic Drug Interactions in Anaesthetic Practice

  • Margaret Wood
Review Articles Pharmacokinetic Drug Interactions

Summary

Patients receive on average 10 different drugs while in hospital; when fewer than 6 are administered the probability of an adverse drug interaction is about 5%, but when more than 15 are given the probability increases to over 40%. Patients presenting for anaesthesia and surgery are likely to receive multiple preoperative drug therapy and also many perioperative medications as part of their anaesthetic regimen. Thus, there is a considerable potential for interactions to occur in anaesthetic practice.

Pharmacokinetic interactions occur when the administration of 1 drug alters the disposition of another, and hence alters the concentration of drug at the receptor site, leading to altered drug response. These changes in drug concentration at the receptor site may be produced by alteration of (a) drug absorption and uptake into the body, (b) drug distribution, (c) drug metabolism and (d) drug elimination or excretion by nonmetabolic routes.

Interactions affecting the absorption of orally administered medications are often due to the indirect effect of 1 drug on gastric motility and emptying, which leads to reduced, delayed or variable systemic drug availability. Gastric emptying time before elective surgery is normal, but premedication with morphine, pethidine (meperidine) and anticholinergics all delay gastric emptying and hence drug absorption. Inhalational anaesthesia of short duration does not appear to affect drug absorption, although halothane anaesthetic used for longer periods produces a slight delay in gastric emptying. Volatile anaesthetics have been shown to delay the intramuscular absorption of ketamine.

Anaesthetic agents may affect drug distribution, and peak concentrations of propranolol, for example, are 4 times higher during halothane anaesthesia in dogs, accompanied by a marked decrease in volume of distribution. This effect has been noted for other drugs, including thiopental and verapamil. Volatile anaesthetics also affect plasma protein binding, leading to displacement interactions in some cases.

Volatile anaesthetics affect the metabolism of concomitantly administered drug (a) by altering the rate of delivery to the organ of clearance (e.g. decreasing hepatic blood flow) and (b) by altering the activity of drug metabolising enzymes. It is now well recognised that all the volatile anaesthetics currently in use inhibit the metabolism of a large variety of drugs, e.g. propranolol, lidocaine (lignocaine), fentanyl and pethidine. Other examples of interactions of clinical importance to anaesthesiologists include those between Cimetidine and the local anaesthetics and benzodiazepines; inhibition of plasma Cholinesterase by drugs such as ecothiopate; interactions between monoamine oxidase inhibitors and sympathomimetics or pethidine and between isoniazid and enflurane. Although the clinical importance of pharmacokinetic drug interactions may have been overemphasised in the past, the potential for drug interactions to occur in anaesthetic practice remains substantial.

Keywords

Morphine Cimetidine Halothane Gastric Emptying Bupivacaine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adelhoj B, Petring OU, Erin-Madsen J, Angelo H, Jelert H. General analgesia with halothane and drug absorption: the effect of general anaesthesia with halothane and diazepam on postoperative gastric emptying in man. Acta Anaesthesiologica Scandinavica 28: 390–392, 1984PubMedCrossRefGoogle Scholar
  2. Adjepon-Yamoah KK, Scott DB, Prescott LF. Impaired absorption and metabolism of oral lignocaine in patients undergoing laparoscopy. British Journal of Anaesthesia 45: 143–147, 1973PubMedCrossRefGoogle Scholar
  3. Altmayer P, Buch U, Hutschenreuter K, Buch HP. The volatile anesthetics, halothane, enflurane and isoflurane, influence the distribution of thiopental in man differently. Acta Anaesthesiologica Scandinavica 31: 756–761, 1987PubMedCrossRefGoogle Scholar
  4. Arakawa Y, Bandoh M, Ogasawara H, Tanaka H, Nishida N, et al. Pharmacokinetics of pentazocine in dogs under halothane anesthesia. Chemical and Pharmaceutical Bulletin 27: 2217–2220, 1979CrossRefGoogle Scholar
  5. Balasabramanian D, Wetlaufer DB. Reversible alteration of the structure of globular proteins by anesthetic agents. Proceedings of the National Academy of Sciences of the United States of America 55: 762–765, 1966CrossRefGoogle Scholar
  6. Bartkowski RR, Goldberg ME, Larijani GM, Boerner TF. Inhibition of alfentanil metabolism by erythromycin. Clinical Pharmacology and Therapeutics 46: 99–102, 1989PubMedCrossRefGoogle Scholar
  7. Bell LE, Slattery JT, Calkins DF. Effect of halothane-oxygen anesthesia on the pharmacokinetics of diazepam and its metabolites in rats. Journal of Pharmacology and Experimental Therapeutics 233: 94–99, 1985PubMedGoogle Scholar
  8. Bennett EJ, Schmidt GB, Patel KP, Grundy EM. Muscle relaxants, myasthenia and mustards? Anesthesiology 46: 220–221, 1977PubMedCrossRefGoogle Scholar
  9. Bentley JB, Glass S, Gandolfi AJ. The influence of halothane on lidocaine pharmacokinetics in man. Anesthesiology 59: A246, 1983Google Scholar
  10. Berger JM, Stirt JA, Sullivan SF. Enflurane, halothane and aminophylline uptake and pharmacokinetics. Anesthesia and Analgesia 62: 733–777, 1983PubMedCrossRefGoogle Scholar
  11. Borel JD, Bentley JB, Nenad RE, Gillespie TJ. The influence of halothane on fentanyl pharmacokinetics. Anesthesiology 57: A239, 1982CrossRefGoogle Scholar
  12. Boyce JR, Cervenko FW, Wright FJ. Effects of halothane on the pharmacokinetics of lidocaine in digitalis-toxic dogs. Canadian Anaesthetists Society Journal 25: 323–328, 1978PubMedCrossRefGoogle Scholar
  13. Brown BR. The diphasic action of halothane on the oxidative metabolism of drugs by the liver: an in vitro study in the rat. Anesthesiology 35: 241–246, 1971PubMedCrossRefGoogle Scholar
  14. Bruce DL. Anesthetic-induced increase in murine mortality from cyclophosphamide. Cancer 31: 36–363, 1973CrossRefGoogle Scholar
  15. Buch HP, Altmayer P, Buch U. Thiopental binding to human serum albumin in the presence of halothane. Acta Anaesthesiologica Scandinavica 34: 35–40, 1990PubMedGoogle Scholar
  16. Burney RG, DiFazio CA. Hepatic clearance of lidocaine during N2O anesthesia in dogs. Anesthesia and Analgesia 55: 322–325, 1976PubMedCrossRefGoogle Scholar
  17. Calvo R, Aguilera L, Suarez E, Rodriguez-Sasain JM. Displacement of warfarin from human serum proteins by halothane anesthesia. Acta Anaesthesiologica Scandinavica 33: 575–577, 1989PubMedCrossRefGoogle Scholar
  18. Chelly JE, Hysing ES, Abernethy DR, Doursout MF, Hartley CT, et al. Role of isoflurane on hemodynamic properties and disposition of nicardipine. Journal of Pharmacology and Therapeutics 241: 899–906, 1987Google Scholar
  19. Chelly JE, Hysing ES, Abernethy DR, Doursout MF, Merin RG. Effects of inhalational anesthetics on verapamil pharmacokinetics in dogs. Anesthesiology 65: 266–271, 1986aPubMedCrossRefGoogle Scholar
  20. Chelly JE, Hysing ES, Abernethy DS, Doursout MF, Merin RG. Effects of inhalational anesthetics on verapamil pharmacokinetics in dogs. Anesthesiology 65: 266–271, 1986cPubMedCrossRefGoogle Scholar
  21. Chelly JE, Rogers K, Hysing ES, Taylor A, Hartley C, et al. Cardiovascular effects of an interaction between calcium blocking drugs and anesthetics in chronically instrumented dogs: I. Verapamil and halothane. Anesthesiology 64: 560–567, 1986bPubMedCrossRefGoogle Scholar
  22. Cherksey BD, Altszuler N. On the mechanism of potentiation by morphine on thiopental sleeping time. Pharmacology 12: 362–371, 1974PubMedCrossRefGoogle Scholar
  23. Clark B, Thompson JW. Analysis of the inhibition of pethidine N-demethylation by monoamine oxidase inhibitors and some other drugs with special reference to drug interactions in man. British Journal of Pharmacology 44: 89–99, 1972PubMedCrossRefGoogle Scholar
  24. Clark JM, Seager SJ. Gastric emptying following premedication with glycopyrrolate or atropine. British Journal of Anaesthesia 55: 1195–1199, 1983PubMedCrossRefGoogle Scholar
  25. Cousins MJ, Greenstein LR, Hitt BA, Mazze RI. Metabolism and renal effects of enflurane in man. Anesthesiology 44: 44–53, 1976PubMedCrossRefGoogle Scholar
  26. Csogor SI, Kerek SF. Enhancement of thiopental anaesthesia by sulphafurazole. British Journal of Anaesthesia 42: 988–990, 1970PubMedCrossRefGoogle Scholar
  27. Dailey PA, Hughes SC, Rosen MA, Healy K, Cheek DB, et al. Effect of Cimetidine and ranitidine on lidocaine concentrations during epidural anesthesia for cesarean section. Anesthesiology 69: 1013–1017, 1988PubMedCrossRefGoogle Scholar
  28. Dale O. The interaction of enflurane, halothane and the halothane metabolite trifluoroacetic acid with the binding of acidic drugs to human serum albumin: an in vitro study. Biochemical Pharmacology 35: 557–561, 1986PubMedCrossRefGoogle Scholar
  29. Dale O, Gandolfi AJ, Brendel K, Schuman S. Rat liver slices and diazepam metabolism: in vitro interactions with volatile anaesthetic drugs and albumin. British Journal of Anaesthesia 60: 692–696, 1988PubMedCrossRefGoogle Scholar
  30. Dale O, Nilsen OG. Displacement of some basic drugs from human serum proteins by enflurane, halothane and their major metabolites. British Journal of Anaesthesia 56: 535–542, 1984PubMedCrossRefGoogle Scholar
  31. Denson D, Coyle D, Thompson G, Myers J. Alpha1-acid glycoprotein and albumin in human serum bupivacaine binding. Clinical Pharmacology and Therapeutics 35: 409–415, 1984aPubMedCrossRefGoogle Scholar
  32. Denson DD, Coyle DE, Thompson GA, Santos D, Turner PA, et al. Bupivacaine protein binding in the term parturient: effects of lactic acidosis. Clinical Pharmacology and Therapeutics 35: 702–709, 1984bPubMedCrossRefGoogle Scholar
  33. Desmond PV, Mashford ML, Harman PJ, Morphett BJ, Breen KJ, et al. Decreased oral warfarin clearance after ranitidine and Cimetidine. Clinical Pharmacology and Therapeutics 35: 338–341, 1984PubMedCrossRefGoogle Scholar
  34. Donati F, Bevan DR. Controlled succinylcholine infusion in a patient receiving echothiophate eye drops. Canadian Anaesthetists Society Journal 28: 488–490, 1981PubMedCrossRefGoogle Scholar
  35. Eade NR, Renton KW. The effect of phenelzine and tranylcypromine on the degradation of meperidine. Journal of Pharmacology and Experimental Therapeutics 173: 31–36, 1970PubMedGoogle Scholar
  36. Eger II EI. The pharmacology of isoflurane. British Journal of Anaesthesia 56: 71S–99S, 1984PubMedGoogle Scholar
  37. El-Ganzouri AR, Ivankovich AD, Braverman B, McCarthy R. Monoamine oxidase inhibitors: should they be discontinued preoperatively. Anesthesia and Analgesia 64: 592–596, 1985PubMedCrossRefGoogle Scholar
  38. Evans-Prosser CDG. The use of pethidine and morphine in the presence of monoamine oxidase inhibitors. British Journal of Anaesthesia 40: 279–282, 1968PubMedCrossRefGoogle Scholar
  39. Fee JPH, Collier PS, Howard PJ, Dundee JW. Cimetidine and ranitidine increase midazolam bioavailability. Clinical Pharmacology and Therapeutics 41: 80–84, 1987PubMedCrossRefGoogle Scholar
  40. Feely J, Wilkinson GR, McAllister C, Wood AJJ. Increased toxicity and reduced clearance of lidocaine by Cimetidine. Annals of Internal Medicine 96: 592–594, 1982PubMedGoogle Scholar
  41. Feely J, Wilkinson GR, Wood AJJ. Reduction of liver blood flow and propranolol metabolism by Cimetidine. New England Journal of Medicine 304: 692–695, 1981PubMedCrossRefGoogle Scholar
  42. Fine A, Churchill DN. Potentially lethal interaction of Cimetidine and morphine. Canadian Medical Association Journal 124: 1434–1436, 1981PubMedGoogle Scholar
  43. Fiserova-Bergerova V, Dolan DF. Transient inhibitory effect of isoflurane upon oxidative halothane metabolism. Anesthesia and Analgesia 64: 1171–1177, 1985PubMedCrossRefGoogle Scholar
  44. Fish KJ, Rice SA. Halothane inhibits metabolism of enflurane in Fischer 344 rats. Anesthesiology 59: 417–420, 1983PubMedCrossRefGoogle Scholar
  45. Flynn RJ, Moore J, Collier PS, Howard PJ. Effect of intravenous Cimetidine on lignocaine dispositon during extradural caesarean section. Anaesthesia 44: 739–741, 1989PubMedCrossRefGoogle Scholar
  46. Flynn RJ, Moore J, Collier PS, McClean E. Does pretreatment with Cimetidine and ranitidine affect the disposition of bupivacaine? British Journal of Anaesthesia 62: 87–91, 1989PubMedCrossRefGoogle Scholar
  47. Gamble JAS, Gaston JH, Nair SG, Dundee JW. Some pharmacological factors influencing the absorption of diazepam following oral administration. British Journal of Anaesthesia 48: 1181–1185, 1976PubMedCrossRefGoogle Scholar
  48. Ghoneim MM, Pandya H. Plasma protein binding of bupivacaine and its interactions with other drugs in man. British Journal of Anaesthesia 46: 435–438, 1974PubMedCrossRefGoogle Scholar
  49. Gordon L, Wood AJJ, Koshakji RP, Wilkinson GR, Dupont WD, et al. Acute effects of halothane anesthesia on arterial and venous concentrations of propranolol in the dog. Anesthesiology 67: 225–230, 1987PubMedCrossRefGoogle Scholar
  50. Grant IS, Nimmo WS, Clements JA. Lack of effect of ketamine analgesia on gastric emptying in man. British Journal of Anaesthesia 53: 1321–1323, 1981PubMedCrossRefGoogle Scholar
  51. Greenblatt DJ, Abernethy DR, Morse DS, Harmatz JS, Shader RI. Clinical importance of the interaction of diazepam and Cimetidine. New England Journal of Medicine 310: 1639–1643, 1984PubMedCrossRefGoogle Scholar
  52. Greenblatt DJ, Locniskar A, Scavnoe JM, Blyden GT, Ochs HR, et al. Absence of interaction of Cimetidine and ranitidine with intravenous and oral midazolam. Anesthesia and Analgesia 65: 176–180, 1986PubMedGoogle Scholar
  53. Guay DRP, Meatherall RC, Chalmers JL, Grahame GR, Hudson RJ. Ranitidine does not alter pethidine disposition in man. British Journal of Clinical Pharmacology 20: 55–59, 1985PubMedCrossRefGoogle Scholar
  54. Guay DRP, Meatherall RC, Chalmers JL, Grahame GR. Cimetidine alters pethidine disposition in man. British Journal of Clinical Pharmacology 18: 907–914, 1984PubMedCrossRefGoogle Scholar
  55. Gurman GM. Prolonged apnea after succinylcholine in a case treated with cytostatics for cancer. Anesthesia and Analgesia 51: 761–765, 1972PubMedCrossRefGoogle Scholar
  56. Harrington RA, Hamilton CW, Brogden RN, Linkewich JA, Romankiewizc JA, et al. Metoclopramide: an updated review of its pharmacological properties and clinical use. Drugs 25: 451–494, 1983PubMedCrossRefGoogle Scholar
  57. Havdala HS, Borison RL, Diamond BI. Potential hazards and applications of lithium in anesthesiology. Anesthesiology 50: 534–537, 1979PubMedCrossRefGoogle Scholar
  58. Herman RJ, Nakamura K, Wilkinson GR, Wood AJJ. Induction of propranolol metabolism by rifampicin: British Journal of Clinical Pharmacology 16: 565–569, 1983PubMedCrossRefGoogle Scholar
  59. Hiller A, Olkkola KT, Isohanni P, Saarnivarra L. Unconsciousness associated with midazolam and erythromycin. British Journal of Anaesthesia 65: 826–828, 1990PubMedCrossRefGoogle Scholar
  60. Idvall J, Aronsen KF, Stenberg P, Paalzow L. Pharmacodynamic and pharmacokinetic interactions between ketamine and diazepam. European Journal of Clinical Pharmacology 24: 337–343, 1983PubMedCrossRefGoogle Scholar
  61. Jensen JF, Gugler R. Cimetidine interaction with liver microsomes in vitro and in vivo: involvement of an activated complex with cytochrome P-450. Biochemical Pharmacology 34: 2141–2146, 1985PubMedCrossRefGoogle Scholar
  62. Jick H, Miettinen OS, Shapiro S, Lewis GP, Siskind V, et al. Comprehensive drug surveillance. Journal of the American Medical Association 213: 1455–1460, 1970PubMedCrossRefGoogle Scholar
  63. Kapur PA, Bloor BC, Flacke WE, Olewine SK. Comparison of cardiovascular responses to verapamil during enflurane, isoflurane or halothane anesthesia in the dog. Anesthesiologist 61: 156–160, 1984CrossRefGoogle Scholar
  64. Karlin JM, Kutt H. Acute diphenylhydantoin intoxication following halothane anesthesia. Pediatric Pharmacology and Therapeutics 76: 941–944, 1970Google Scholar
  65. Kaukinen S, Eerola M, Ylitalo P. Prolongation of thiopentone anaesthesia by probenecid. British Journal of Anaesthesia 52: 603–607, 1980PubMedCrossRefGoogle Scholar
  66. Klotz U, Arvela P, Rosenkranz B. Effect of single doses of Cimetidine and ranitidine on the steady state plasma levels of midazolam. Clinical Pharmacology and Therapeutics 38: 652–655, 1985PubMedCrossRefGoogle Scholar
  67. Klotz U, Avant GR, Hoyumpa A, Schenker S, Wilkinson GR. The effect of age and disease on the disposition and elimination of diazepam in adult man. Journal of Clinical Investigation 55: 347–359, 1975PubMedCrossRefGoogle Scholar
  68. Klotz U, Reimann I. Delayed clearance of diazepam due to Cimetidine. New England Journal of Medicine 302: 1012–1014, 1980PubMedCrossRefGoogle Scholar
  69. Kuhnert BR, Zuspan JK, Kuhnert PM, Syracuse CD, Brashear WT, et al. Lack of influence of Cimetidine on bupivacaine levels during parturition. Anaesthesia and Analgesia 66: 986–990, 1987Google Scholar
  70. Lam AM, Clement JL. Effect of Cimetidine premedication on morphine-induced ventilatory depression. Canadian Anaesthetists Society Journal 31: 36–43, 1984PubMedCrossRefGoogle Scholar
  71. Lee JT, Erbguth PH, Stevens WC. Failure to detect toxicity with the concomitant use of cyclophosphamide and halothane in humans. Anesthesiology 64: 810–811, 1986PubMedCrossRefGoogle Scholar
  72. Lehmann KA, Weski C, Hunger L, Henrich C, Daub D. Biotransformation of fentanyl: II. Acute drug interactions in rats and men. Anaesthetist 31: 221–227 1982Google Scholar
  73. Levy WJ. Clinical anaesthesia with isoflurane. British Journal of Anaesthesia 56 (Suppl. 1): 101S–112S 1984PubMedGoogle Scholar
  74. MacKenzie JE, Frank LW. Influence of pretreatment with a monoamine oxidase inhibitor (Phenelzine) on the effects of buprenorphine and pethidine in the conscious rabbit. British Journal of Anaesthesia 60: 216–221, 1988PubMedCrossRefGoogle Scholar
  75. Manchikanti L, Kraus JW, Edds SP. Cimetidine and related drugs in anesthesia. Anesthesia and Analgesia 61: 595–608, 1982PubMedCrossRefGoogle Scholar
  76. Marsh RHK, Spencer R, Nimmo WS. Gastric emptying and drug absorption before surgery. British Journal of Anaesthesia 56: 161–164, 1984PubMedCrossRefGoogle Scholar
  77. Mather LE, Runciman WB, Carapetis RJ, Ilsley A, Upton RN. Hepatic and renal clearance of lidocaine in conscious and anesthetized sheep. Anesthesia and Analgesia 65: 943–949, 1986aPubMedCrossRefGoogle Scholar
  78. Mather LE, Runciman WB, Ilsley AH, Carapetis RJ, Upton RN. A sheep preparation for studying interactions between blood flow and drug disposition: V. The effects of general and subarachnoid anaesthesia on blood flow and pethidine disposition. British Journal of Anaesthesia 58: 888–896, 1986bPubMedCrossRefGoogle Scholar
  79. Mather LE, Selby DG, Runciman WB. Effects of propofol and of thiopentone anaesthesia on the regional kinetics of pethidine in the sheep. British Journal of Anaesthesia 65: 365–372, 1990PubMedCrossRefGoogle Scholar
  80. Mazze RI. Metabolism of the inhaled anaesthetics: implications of enzyme induction. British Journal of Anaesthesia 56: 27S–41S, 1984PubMedGoogle Scholar
  81. Mazze RI, Woodruff RE, Heerdt ME. Isoniazid-induced enflurane defluorination in humans. Anesthesiology 57: 5–8, 1982PubMedCrossRefGoogle Scholar
  82. Merrell WJ, Gordon L, Wood AJ, Shay S, Jackson EK, et al. The effect of halothane on morphine disposition: relative contributions of the liver and kidney to morphine glucuronidation in the dog. Anesthesiology 72: 308–314, 1990PubMedCrossRefGoogle Scholar
  83. Michaels I, Serrins M, Shier NQ, Barash PG. Anesthesia for cardiac surgery in patients receiving monoamine oxidase inhibitors. Anesthesia and Analgesia 63: 1041–1044, 1984PubMedGoogle Scholar
  84. Miller RR. Drug surveillance utilizing epidemiologic methods: a report from the Boston Collaborative Drug Surveillance Program. American Journal of Hospital Pharmacy 30: 584–592, 1973PubMedGoogle Scholar
  85. Mirakhur RK, Fernes CJ, Lavery TD. Plasma Cholinesterase levels following pancuronium and vecuronium. Acta Anaesthesiologica Scandinavica 27: 451–453, 1983PubMedCrossRefGoogle Scholar
  86. Mojaverian P, Fedder IL, Vlasses PH, Rotmensch H, Rocci JL, et al. Cimetidine does not alter morphine disposition in man. British Journal of Clinical Pharmacology 14: 809–813, 1982PubMedCrossRefGoogle Scholar
  87. Morgan M. Control of intragastric pH and volume. British Journal of Anaesthesia 56: 47–57, 1984PubMedCrossRefGoogle Scholar
  88. Mouton-Perry S, Whelan E, Shay S, Wood AJJ. Wood M. The effect of intravenous anesthesia with propofol on drug distribution and metabolism in the dog: lack of effect of intravenous fat emulsion. British Journal of Anesthesiology 61: 66–72, 1991CrossRefGoogle Scholar
  89. Nakatsu K. Anesthetics and theophylline metabolism. Anesthesia and Analgesia 64: 456–463, 1985CrossRefGoogle Scholar
  90. Nimmo AWS, Wilson J, Prescott LF. Narcotic analgesics and delayed gastric emptying during labour. Lancet 1: 890–893, 1975PubMedCrossRefGoogle Scholar
  91. Nimmo WS. Effect of anaesthesia on gastric motility and emptying. British Journal of Anaesthesia 56: 29–36, 1984PubMedCrossRefGoogle Scholar
  92. Noble DW, Smith JK, Dundas CR. Effects of H2-antagonists on the elimination of bupivacaine. British Journal of Anaesthetics 59: 735–737, 1987CrossRefGoogle Scholar
  93. Oikkonen M, Rosenberg PH, Saarnivaara L. Cimetidine and ranitidine do not affect enflurane metabolism in surgical patients. Acta Anaesthesiologica Scandinavica 33: 129–131, 1989PubMedCrossRefGoogle Scholar
  94. Orme M. Drug absorption in the gut. British Journal of Anaesthesia 55: 59–67, 1984CrossRefGoogle Scholar
  95. O’Sullivan GM, Smith M, Morgan B, Brighouse D, Reynolds H: H2 antagonists and bupivacaine clearance. Anaesthesia 43: 93–95, 1988PubMedCrossRefGoogle Scholar
  96. Pantuck EJ. Ecothiopate idide eye drops and prolonged response to suxamethonium: a case report. British Journal of Anaesthetics 38: 406–407, 1966CrossRefGoogle Scholar
  97. Pearson GR, Bogan JA, Sanford J. An increase in the half-life of pentobarbitone with the administration of halothane in sheep. British Journal of Anaesthesia 45: 586–588, 1973PubMedCrossRefGoogle Scholar
  98. Plummer JL, Wanwimolruk S, Jenner MA, de la M Hall P, Cousins MJ. Effects of Cimetidine and ranitidine on halothane metabolism and hepatotoxicity in an animal model. Drug Metabolism and Disposition 12: 106–110, 1984PubMedGoogle Scholar
  99. Prince RA, Wing DS, Weingberger MM, Hendeles LS, Riegelman S. Effect of erythromycin theophylline kinetics. Journal of Allergy and Clinical Immunology 68: 427–431, 1981PubMedCrossRefGoogle Scholar
  100. Reilly CS, Biollaz J, Koshakji RP, Wood AJJ. Enprostil, in contrast to Cimetidine, does not inhibit hepatic drug metabolism. Clinical Pharmacology and Therapeutics 40: 37–41, 1986PubMedCrossRefGoogle Scholar
  101. Reilly CS, Merrell WJ, Wood AJJ, Koshakji RP, Wood M. Comparison of the effects of isoflurane and fentanyl-nitrous oxideatracurium anesthesia on propranolol disposition in the dog. British Journal of Anaesthesia 60: 791–796, 1988PubMedCrossRefGoogle Scholar
  102. Reilly CS, Nimmo WS. Drug absorption after general anaesthesia for minor surgery. Anaesthesia 39: 859–861, 1984PubMedCrossRefGoogle Scholar
  103. Reilly CS, Wood AJJ, Koshakji R, Wood M. The effect of halothane on drug disposition: contribution of changes in intrinsic drug metabolizing capacity and hepatic blood flow. Anesthesiology 63: 70–76, 1985PubMedCrossRefGoogle Scholar
  104. Rendic S, Kajfez F, Ruf H-H. Characterization of Cimetidine, ranitidine, and related structures interaction with cytochrome P-450. Drug Metabolism and Disposition 11: 137–142, 1983PubMedGoogle Scholar
  105. Renton KW, Eade NR. Microsomal enzymes and potentiation of tyramine pressor response. Biochemical Pharmacology 21: 1393–1402, 1972PubMedCrossRefGoogle Scholar
  106. Rice SA, Talcot RE. Effects of isoniazid treatment on selected hepatic mixed function oxidases. Drug Metabolism and Disposition 7: 260–262, 1979PubMedGoogle Scholar
  107. Rogers KJ, Thornton JA. The interaction between monoamine oxidase inhibitors and narcotic analgesics in mice. British Journal of Pharmacology 36: 470–480, 1969PubMedCrossRefGoogle Scholar
  108. Rogers K, Hysing ES, Merin R, Taylor A, Hartley C, et al. Cardiovascular effects and interactions between calcium blocking drugs and anesthetics in chronically instrumented dogs: II. Verapamil, enflurane and isoflurane. Anesthesiology 64: 568–575, 1986PubMedCrossRefGoogle Scholar
  109. Rosenow S, Kooistra KL, Powis G, Van Dyke RA. Increased toxicity of the antitumor drug cyclophosphamide in mice in the presence of the volatile anesthetic agent halothane. Cancer Chemotherapy and Pharmacology 16: 35–42, 1986PubMedCrossRefGoogle Scholar
  110. Runciman WB, Ilsley AH, Mather LE, Carapetis R, Rao MM. A sheep preparation for studying interactions between blood flow and drug disposition: I. Physiological profile. British Journal of Anaesthesia 56: 1015–1028, 1984PubMedCrossRefGoogle Scholar
  111. Runciman WB, Mather LE, Ilsley AH, Carapetis RJ, Upton RN. A sheep preparation for studying interactions between blood flow and drug disposition: VI. Effects of general or subarachnoid anaesthesia on blood flow and chlormethiazole disposition. British Journal of Anaesthesia 58: 1308–1316, 1986PubMedCrossRefGoogle Scholar
  112. Salem RB, Mojaverian P, Swanson BN, Vlasses PH, Ferguson RK. Potentially lethal interaction of Cimetidine and morphine. Canadian Medical Association Journal 125: 1212–1213, 1981Google Scholar
  113. Sear JW, Hand CW, Moore RA, McQuay HJ. Studies on morphine disposition: influence of general anaesthesia on plasma concentrations of morphine and its metabolites. British Journal of Anaesthesia 62: 22–27, 1989PubMedCrossRefGoogle Scholar
  114. Sellars EM, Koch-Weser J. Potentiation of warfarin-induced hypoprothrombinemia by chloral hydrate. New England Journal of Medicine 283: 827–831, 1970CrossRefGoogle Scholar
  115. Serlin MJ, Breckenridge AM. Drug interactions with warfarin. Drugs 25: 610–620, 1983PubMedCrossRefGoogle Scholar
  116. Shull HJ, Wilkinson GR, Johnson R, Shenker S. Normal disposition of oxazepam in acute viral hepatitis and cirrhosis. Annals of Internal Medicine 84: 420–425, 1976PubMedGoogle Scholar
  117. Sides CA. Hypertension during anaesthesia with monoamine oxidase inhibitors. Anaesthesia 42: 633–635, 1987PubMedCrossRefGoogle Scholar
  118. Smith SR, Kendall MJ. Ranitidine versus Cimetidine. A comparison of their potential to cause clinically important drug interactions. Clinical Pharmacokinetics 15: 44–56, 1988PubMedCrossRefGoogle Scholar
  119. Somogyi A, Gugler R. Drug interactions with Cimetidine. Clinical Pharmacokinetics 7: 23–41, 1982PubMedCrossRefGoogle Scholar
  120. Somogyi A, Muirhead M. Pharmacokinetic interactions of Cimetidine 1987. Clinical Pharmacokinetics 12: 321–366, 1987PubMedCrossRefGoogle Scholar
  121. Stack CG, Rogers P, Linter SPK. Monoamine oxidase inhibitors and anaesthesia: a review. British Journal of Anaesthesia 60: 222–227, 1988PubMedCrossRefGoogle Scholar
  122. Steffey EP, Martucci R, Howland D, Asling JH, Eisele JH. Meperidine-halothane interaction in dogs. Canadian Anaesthetists Society Journal 24: 459–467, 1977PubMedCrossRefGoogle Scholar
  123. Todd JG, Nimmo WS. Effect of premedication on drug absorption and gastric emptying. British Journal of Anaesthesia 55: 1189–1193, 1983PubMedCrossRefGoogle Scholar
  124. Tucker GT, Mather LE. Plasma protein binding of bupivacaine and its interactions with other drugs in man. British Journal of Anaesthesia 47: 1029–1030, 1975PubMedCrossRefGoogle Scholar
  125. Vigran IM. Dangerous potentiation of meperidine hydrochloride by pargyline hydrochloride. Journal of the American Medical Association 187: 953–954, 1964PubMedCrossRefGoogle Scholar
  126. Wells DG, Bjorksen AR. Monoamine oxidase inhibitors revisited. Canadian Journal of Anaesthesia 36: 64–74, 1989PubMedCrossRefGoogle Scholar
  127. Whelan E, Wood AJJ, Koshakji R, Shay S, Wood M. Halothane inhibition of propranolol metabolism is stereoselective. Anesthesiology 71: 561–564, 1989aPubMedCrossRefGoogle Scholar
  128. Whelan E, Wood AJJ, Shay S, Wood M. Lack of effect of spinal anesthesia on drug metabolism. Anesthesia and Analgesia 69: 307–312, 1989bPubMedCrossRefGoogle Scholar
  129. White PF, Johnston RR, Pudwill CR. Interaction of ketamine and halothane in rats. Anesthesiology 42: 179–186, 1975PubMedCrossRefGoogle Scholar
  130. White PF, Marietta MP, Pudwill CR, Way WL, Trevor AJ. Effects of halothane anesthesia on the biodisposition of ketamine in rats. Journal of Pharmacology and Experimental Therapeutics 196: 545–555, 1976PubMedGoogle Scholar
  131. White PF, Shuttler J, Shafer A, Stanski DR, Horai Y, et al. Comparative pharmacology of the ketamine isomers. British Journal of Anaesthesia 57: 197–203, 1985PubMedCrossRefGoogle Scholar
  132. Williams JG. H2 Receptor antagonists and anaesthesia. Canadian Anaesthetists Society Journal 30: 264–269, 1983PubMedCrossRefGoogle Scholar
  133. Wood M. Plasma drug binding: implications for anesthesiologists. Anesthesia and Analgesia 65: 786–804, 1986PubMedGoogle Scholar
  134. Wood M. Inhalational anesthetic agents. In Wood & Wood (Eds) Drugs and anesthesia: pharmacology for anesthesiologists, Williams & Wilkins, Baltimore, 1990Google Scholar
  135. Wood M, Uetrecht J, Phythyon JM, Shay S, Sweetman BJ, et al. The effect of Cimetidine on anesthetic metabolism and toxicity. Anesthesia and Analgesia 65: 481–488, 1986PubMedGoogle Scholar
  136. Wood M, Whelan E, Shay S, Wood AJJ. Acute effect of halothane on drug distribution. Anesthesiology 71: A259, 1989CrossRefGoogle Scholar
  137. Wood M, Wood AJJ. Contrasting effects of halothane, isoflurane and enflurane on in vivo drug metabolism in the rat. Anesthesia and Analgesia 63: 709–714, 1984PubMedCrossRefGoogle Scholar
  138. Yeager MP, Coombs DW, Dodge CP, Maloney LA. Effect of Cimetidine on biotransformation of enflurane in man. Canadian Anaesthetists Society Journal 33: 466–470, 1986PubMedCrossRefGoogle Scholar
  139. Ying Yu H, Sawada Y, Sugiyama Y, Iga T, Hanano M. Effect of sulfadimethoxine on thiopental distribution and elimination in rats. Journal of Pharmaceutical Sciences 70: 323–326, 1981CrossRefGoogle Scholar
  140. Zarowit BJM, Szefler SJ, Lasezkay GM. Effect of erythromycin base on theophylline kinetics. Clinical Pharmacology and Therapeutics 29: 601–605, 1981CrossRefGoogle Scholar
  141. Zsigmond EK, Robins G. The effect of a series of anti-cancer drugs on plasma Cholinesterase activity. Canadian Anaesthetists Society Journal 19: 75–82, 1972PubMedCrossRefGoogle Scholar

Copyright information

© Adis International Limited 1991

Authors and Affiliations

  • Margaret Wood
    • 1
  1. 1.Departments of Anesthesiology and PharmacologyVanderbilt University School of MedicineNashvilleUSA

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