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Single-Dose and Steady-State Pharmacokinetics of Doxazosin Given in Combination with Chlorothiazide to Hypertensive Subjects

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Summary

The pharmacokinetics of doxazosin were determined in hypertensive subjects after a single dose of 1mg, and at steady-state while receiving doses of 1, 2, 4 and 8mg of the drug daily. Chlorothiazide 500mg once daily was administered as additional therapy throughout the study. After a single dose doxazosin was rapidly absorbed, with peak plasma drug concentrations (Cmax) occurring after 2.1 ± 0.4 hours. The elimination half-life in plasma was 10.7 ± 1.2 hours. These parameters remained essentially unchanged during maintenance administration of doxazosin at each of the dose levels. Calculations of Cmax and area under the concentration-time curve (A UC0→∞) indicated that the pharmacokinetic disposition of the drug remained linear over the dose range 1 to 8mg.

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Authors and Affiliations

  1. Clinical Pharmacology and Therapeutics Units, Austin Hospital, University of Melbourne, Heidelberg, Victoria, 3084, Australia

    E. L. Conway, J. J. McNeil, L. Meng, O. H. Drummer, L. G. Howes, K. Raymond & W. J. Louis

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  1. E. L. Conway
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  2. J. J. McNeil
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  3. L. Meng
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  4. O. H. Drummer
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  5. L. G. Howes
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  6. K. Raymond
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  7. W. J. Louis
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Conway, E.L., McNeil, J.J., Meng, L. et al. Single-Dose and Steady-State Pharmacokinetics of Doxazosin Given in Combination with Chlorothiazide to Hypertensive Subjects. Clin-Pharmacokinet 16, 387–391 (1989). https://doi.org/10.2165/00003088-198916060-00004

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  • DOI: https://doi.org/10.2165/00003088-198916060-00004

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