Skip to main content
SpringerLink
Log in

Unique Aspects of Quinolone Pharmacokinetics

  • Published:
Clinical Pharmacokinetics Aims and scope Submit manuscript

Summary

Despite some limited differences in pharmacokinetic parameters among the newer quinolones, their pharmacology is characterised by high volumes of distribution, long elimination half-lives, good to excellent bioavailability, low protein binding, limited biotransformation and different elimination pathways (mainly through the kidneys). The unique aspects of quinolones in comparison with β-lactams and aminoglycosides are their higher volumes of distribution, longer elimination half-lives and their intracellular high concentration, especially in phagocytic cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Borner K, Höffken G, Lode H, Koeppe P, Prinzing C, et al. Pharmacokinetics of ciprofloxacin in healthy volunteers after oral and intravenous administration. European Journal of Clinical Microbiology 5: 179–186, 1986

    Article  PubMed  CAS  Google Scholar 

  • Borner K, Lode H. Biotransformation von ausgewählten Gyrasehemmern. Infection 14 (Suppl. 1): 54–59, 1986

    Article  Google Scholar 

  • Drusano GL, Standiford HC, Plaisance K, Forrest A, Leslie J, et al. Absolute oral bioavailability of ciprofloxacin. Antimicrobial Agents and Chemotherapy 30: 444–446, 1986

    Article  PubMed  CAS  Google Scholar 

  • Höffken G, Lode H, Prinzing C, Borner U, Koeppe P. Pharmacokinetics of ciprofloxacin after oral and parenteral administration. Antimicrobial Agents and Chemotherapy 27: 375–379, 1985

    Article  PubMed  Google Scholar 

  • Höffken G, Lode H, Wiley R, Glatzel TD, Sievers D. et al. Pharmacokinetics and bioavailability of ciprofloxacin and ofloxacin: effect of food and antacid intake. Reviews of Infectious Diseases 10 (Suppl. 1): 138–139, 1988

    Google Scholar 

  • Höffler D, Dalhoff A, Gau W, Beermann D, Michl A. Dose- and sex-independent disposition of ciprofloxacin. European Journal of Clinical Microbiology 3: 363–366, 1984

    Article  PubMed  Google Scholar 

  • Humbert G, Brosa R, Couet W, Fourtillan JB, Vincent de Laurier M, et al. Pharmacokinetics of ofloxacin in young healthy subjects (abstract) 14th International Congress of Chemotherapy, Kyoto, 1985

  • Jack DB, Wilkins MR, Laugher SJ, Kendall MJ, Wise R. A clinical pharmacokinetic study of ciprofloxacin administered chronically as iv bolus doses to young healthy volunteers (abstract S-41-12) 14th International Congress of Chemotherapy, Kyoto, 1985

  • Lode H, Höffken G, Olschewski P, Sievers B, Borner K, et al. Pharmacokinetics of ofloxacin after oral and parenteral administration. Antimicrobial Agents and Chemotherapy 31: 1338–1342, 1987a

    Article  PubMed  CAS  Google Scholar 

  • Lode H, Höffken G, Prinzing C, Glatzel P, Wiley R. et al. Comparative pharmacokinetics of new quinolones. Drugs 34 (Suppl. 1): 21–25, 1987b

    Article  PubMed  CAS  Google Scholar 

  • Neuman N. Clinical pharmacokinetics of 4-quinolones. Clinical Pharmacokinetics 14: 96–121, 1988

    Article  PubMed  CAS  Google Scholar 

  • Schwartz J, Jauregni L, Lettieri J, Bachmann K. Impact of ciprofloxacin on theophylline clearance and steady-state concentrations in serum. Antimicrobial Agents and Chemotherapy 32: 75–77, 1988

    Article  PubMed  CAS  Google Scholar 

  • Sörgel F, Brüning I, Stephan U, Lang E. The pharmacokinetics of pefloxacin and its metabolites in healthy volunteers (abstract S-41-10) 14th International Congress of Chemotherapy. Kyoto, 1985

  • Sörgel F, Mahr G, Koch HU, et al. Effects of cimetidine on the pharmacokinetics of pefloxacin in healthy volunteers. Reviews of Infectious Diseases 10 (Suppl. 1): S137. 1988

    Google Scholar 

  • Wijnands W, Van Herwaarden C, Vree T. Enoxacin raises plasma theophylline concentrations. Lancet 2: 108–109, 1984

    Article  PubMed  CAS  Google Scholar 

  • Wingender W, Grade K, Gau W, et al. Pharmacokinetics of ciprofloxacin after oral and IV administration. European Journal of Clinical Microbiology 3: 355–359. 1984

    Article  PubMed  CAS  Google Scholar 

  • Wingender W, Forster W, Beermann D, Rohweder T. Effect of the gastric emptying time on rat and extent of the systemic availability of ciprofloxacin in humans (abstract) 14th International Congress of Chemotherapy, Kyoto, 1985

  • Wise R, Lockley R, Dent J, Webberly M, Pharmacokinetics and tissue penetration of enoxacin. Antimicrobial Agents and Chemotherapy 26: 17–19, 1984

    Article  PubMed  CAS  Google Scholar 

  • Wise R, Lister D, McNully CAM, Griggs D, Andrews JM. The comparative pharmacokinetics of five quinolones. Journal of Antimicrobial Chemotherapy 18 (Suppl. D): 71–81. 1986

    PubMed  CAS  Google Scholar 

  • Wolff M, Regnier B, Baldoss C, Nkam M, Vachon F. Penetration of pefloxacin into cerebrospinal fluid of patients with meningitis. Antimicrobial Agents and Chemotherapy 26: 289–291. 1984

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Department of Klinikum Steglitz, Freie Universität, Hindenburgdamm 30, D-1000, Berlin 45, Federal Republic of Germany

    H. Lode, G. Höffken, K. Borner & P. Koeppe

Authors
  1. H. Lode
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Höffken
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Borner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Koeppe
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lode, H., Höffken, G., Borner, K. et al. Unique Aspects of Quinolone Pharmacokinetics. Clin-Pharmacokinet 16 (Suppl 1), 1–4 (1989). https://doi.org/10.2165/00003088-198900161-00003

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003088-198900161-00003

Keywords

Search

Navigation