Clinical Pharmacokinetics

, Volume 13, Issue 5, pp 334–343 | Cite as

Clinical Pharmacokinetic Significance of the Renal Tubular Secretion of Digoxin

  • Gideon Koren
Research Review


Tubular secretion appears to be a major route of the renal elimination of digoxin. Secretion of the drug by the tubules is modulated by renal blood flow, by a number of commonly coadministered drugs (e.g. quinidine, spironolactone, verapamil, amiodarone), and by age. The maximal transport capacity does not appear to be achieved with clinically relevant concentrations. The tubular transport of digoxin does not appear to be associated with the anionic or cationic transport systems, nor the Na+/K+-ATPase receptor.

Further studies are needed to elucidate the exact mechanisms involved in the transtubular movement of the glycoside.


Digoxin Inulin Quinidine Spironolactone Renal Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© ADIS Press Limited 1987

Authors and Affiliations

  • Gideon Koren
    • 1
    • 2
  1. 1.Department of Clinical PharmacologyThe Hospital for Sick ChildrenTorontoCanada
  2. 2.Department of PediatricsUniversity of TorontoTorontoCanada

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