Clinical Pharmacokinetics

, Volume 9, Issue 4, pp 349–353 | Cite as

Renal Function Related Changes in Lithium Kinetics

  • T. R. Norman
  • R. G. Walker
  • G. D. Burrows
Review Article


The renal clearance of lithium will decrease, and hence the risk of acute lithium toxicity will increase, in any situation leading to dehydration and sodium depletion. Patients on long term lithium therapy with progressively declining urinary concentrating ability may be at special risk in this regard.

Chronic histological changes in the kidney attributed to lithium therapy correlate with age rather than with the duration of lithium therapy. Age-related renal histological changes are associated with decreased glomerular filtration rate and therefore reduced renal lithium clearance. Thus, the dose of lithium should be reduced with advancing age.


Lithium Glomerular Filtration Rate Renal Clearance Lithium Treatment Lithium Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© ADIS Press Limited 1984

Authors and Affiliations

  • T. R. Norman
    • 1
    • 2
  • R. G. Walker
    • 1
    • 2
  • G. D. Burrows
    • 1
    • 2
  1. 1.Department of PsychiatryUniversity of Melbourne Austin and Larundel HospitalsHeidelbergAustralia
  2. 2.Department of NephrologyRoyal Melbourne HospitalParkvilleUSA

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