Clinical Pharmacokinetics

, Volume 4, Issue 5, pp 395–399 | Cite as

Haemoperfusion in the Management of Digoxin Toxicity: Is it Warranted?

  • John T. Slattery
  • Jeffrey R. Koup
Original Article

Summary

Several recent publications have encouraged the use of haemoperfusion to remove digoxin from the body of overdosed patients. The usefulness of haemoperfusion in removing digoxin from the body has therefore been examined using pharmacokinetic simulation techniques and published data. Haemoperfusion for a period of 4 hours with a clearance of 100ml/min removes less than 7% of the amount of digoxin in the body (including that in the gastrointestinal tract at the beginning of haemoperfusion), regardless of the time after the dose that haemoperfusion is started. Dramatic therapeutic benefit in digoxin intoxication is unlikely to be a consequence of the amount of digoxin removed from the body by haemoperfusion. If therapeutic benefit is derived from a transient decline of digoxin concentration in plasma, it may be expected to be negated as the drug redistributes from tissues.

Keywords

Digoxin Digoxin Concentration Transient Decrease Digoxin Toxicity Digitalis Intoxication 

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Copyright information

© ADIS Press Australasia Pty Ltd. 1979

Authors and Affiliations

  • John T. Slattery
    • 1
  • Jeffrey R. Koup
    • 1
  1. 1.From the Departments of Pharmaceutical Sciences and Pharmacy Practice, School of PharmacyUniversity of WashingtonSeattleUSA

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