Clinical Pharmacokinetics

, Volume 4, Issue 1, pp 63–68 | Cite as

Malabsorption of Hydrochlorothiazide Following Intestinal Shunt Surgery

  • L. Backman
  • Bjorn Beermann
  • M. Groschinsky-Grind
  • D. Hallberg
Original Article

Summary

Hydrochlorothiazide 775mg was administered orally to 5 patients who had undergone intestinal shunt operations for obesity 1.5 to 6 years previously. Postoperative weight loss averaged 53.4kg. The concentrations of hydrochlorothiazide in plasma and urine were determined with gas/liquid chromatography. The mean area under the plasma concentration time curve during 9h in 4 of the patients was 889ng/ml · h. Mean total urinary recovery of hydrochlorothiazide amounted to 23.0mg in the 5 patients, which corresponds to approximately half that seen in healthy volunteers. The gastrointestinal hydrochlorothiazide appears to be substantially reduced after intestinal shunt surgery.

Keywords

Hydrochlorothiazide Urinary Recovery Chlorothiazide Thiouracil Postoperative Weight Loss 

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Copyright information

© ADIS Press Australasia Pty Ltd. 1979

Authors and Affiliations

  • L. Backman
    • 1
  • Bjorn Beermann
    • 1
  • M. Groschinsky-Grind
    • 1
  • D. Hallberg
    • 1
  1. 1.Departments of Surgery and Medicine and Clinical Pharmacology LaboratorySerafimerlasarettetStockholmSweden

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