Malabsorption of Hydrochlorothiazide Following Intestinal Shunt Surgery
Hydrochlorothiazide 775mg was administered orally to 5 patients who had undergone intestinal shunt operations for obesity 1.5 to 6 years previously. Postoperative weight loss averaged 53.4kg. The concentrations of hydrochlorothiazide in plasma and urine were determined with gas/liquid chromatography. The mean area under the plasma concentration time curve during 9h in 4 of the patients was 889ng/ml · h. Mean total urinary recovery of hydrochlorothiazide amounted to 23.0mg in the 5 patients, which corresponds to approximately half that seen in healthy volunteers. The gastrointestinal hydrochlorothiazide appears to be substantially reduced after intestinal shunt surgery.
KeywordsHydrochlorothiazide Urinary Recovery Chlorothiazide Thiouracil Postoperative Weight Loss
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- Klein, H.; Kampmann, J.; Lumholtz, B. and Hansen, J.: Drug absorption in intestinal shunt operations. Acta Pharmacologica et Toxicologica 41 (Suppl. IV): 58 (1977).Google Scholar