Drugs & Aging

, Volume 13, Issue 2, pp 173–180 | Cite as


  • Julia A. Balfour
  • Diana Faulds
Adis New Drug Profile


  • ▲ Repaglinide is a novel insulin secretagogue being developed for the management of type 2 (non-insulin-dependent) diabetes mellitus. It stimulates release of insulin from the pancreatic β-cell, but appears to bind to a different receptor site from sulphonylureas.

  • ▲ Repaglinide lowers fasting and postprandial blood glucose levels in animals, healthy volunteers and patients with type 2 diabetes mellitus.

  • ▲ Repaglinide is rapidly absorbed and eliminated, which may allow a relatively fast onset and offset of action. Excretion occurs almost entirely by non-renal mechanisms.

  • ▲ In comparative clinical trials in patients with type 2 diabetes mellitus, repaglinide 0.5 to 4mg twice or 3 times daily before meals provided similar glycaemic control to glibenclamide (glyburide) 2.5 to 15 mg/day. Addition of repaglinide to existing metformin therapy resulted in improved glycaemic control.

  • ▲ In contrast with glibenclamide, use of repaglinide allowed patients to miss a meal without apparently increasing the risk of hypoglycaemia.


Metformin Adis International Limited Glibenclamide Repaglinide Glimepiride 
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Copyright information

© Adis International Limited 1998

Authors and Affiliations

  1. 1.Adis International LimitedMairangi Bay, Auckland 10New Zealand

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