Skip to main content

The Cost of Inappropriate Use of Anti-Infective Agents in Older Patients

This is a preview of subscription content, access via your institution.

References

  1. 1.

    Yoshikawa TT. Antimicrobial therapy for the elderly patient. J Am Geriatr Soc 1990; 38: 1353–72

    PubMed  CAS  Google Scholar 

  2. 2.

    Yoshikawa TT, Norman DC. Antibiotic therapy: what to consider when treating geriatric patients. Hosp Formul 1993; 28: 754–68

    PubMed  CAS  Google Scholar 

  3. 3.

    Norman DC, Grahn D, Yoshikawa TT. Fever and aging. J Am Geriatr Soc 1985; 33: 859–63

    PubMed  CAS  Google Scholar 

  4. 4.

    Lindeman RD, Tobin J, Shock NW. Longitudinal studies on rate of decline in renal function with age. J Am Geriatr Soc 1985; 33: 278–85

    PubMed  CAS  Google Scholar 

  5. 5.

    McCue JD. Antibiotic dosing in renally impaired elderly. P & T 19: 349–62

  6. 6.

    Health Care Financing Administration Office of National Cost Estimates. National health expenditures, 1988. Health Care Financ Rev 1990; 11: 1–41

    Google Scholar 

  7. 7.

    Ives TJ, Bentz EJ, Gwyther RE. Drug-related admissions to a family medicine inpatient service. Arch Intern Med 1987; 147: 1117–20

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Fincham JE. Adverse drug reaction occurrence in elderly patients. J Geriatr Drug Ther 1991; 5: 3–50

    Google Scholar 

  9. 9.

    Grymonpre RE, Mitenko PA, Sitar DS, et al. Drug-associated hospital admissions in older medical patients. J Am Geriatr Soc 1988; 36: 1092–8

    PubMed  CAS  Google Scholar 

  10. 10.

    Lakshanan MC, Hershey CO, Breslau D. Hospital admissions caused by iatrogenic disease. Arch Intern Med 1986; 146: 1931–4

    Article  Google Scholar 

  11. 11.

    Col N, Fanale JE, Kronholm P. The role of medication noncompliance and adverse drug reactions in hospitalizations of the elderly. Arch Intern Med 1990; 150: 841–5

    PubMed  Article  CAS  Google Scholar 

  12. 12.

    Colt HG, Shapiro AP. Drug-induced illness as a cause for admission to a community hospital. J Am Geriatr Soc 1989; 37: 323–6

    PubMed  CAS  Google Scholar 

  13. 13.

    Willcox SM, Himmelstein DU, Woolhandler S. Inappropriate drug prescribing for the community-dwelling elderly. JAMA 1994; 272: 292–315

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Beers MH, Ouslander JG, Fingold SF, et al. Inappropriate medication prescribing in skilled-nursing facilities. Ann Intern Med 1992; 117: 684–9

    PubMed  CAS  Google Scholar 

  15. 15.

    Beers MH, Ouslander JG, Rollingher I, et al. Explicit criteria for determining inappropriate medication use in nursing home residents. Arch Intern Med 1991; 151: 1825–32

    PubMed  Article  CAS  Google Scholar 

  16. 16.

    Cheung R, Sullens CM, Seal D, et al. The paradox of using a 7 day antibacterial course to treat urinary tract infections in the community. Br J Clin Pharmacol 1988; 26: 391–8

    PubMed  Article  CAS  Google Scholar 

  17. 17.

    Cramer JA, Mattson RH, Prevey ML, et al. How often is medication taken as prescribed? JAMA 1989; 261: 3273–7

    PubMed  Article  CAS  Google Scholar 

  18. 18.

    Eisen SA, Miller DK, Woodward RS, et al. The effect of prescribed daily dose frequency on patient medication compliance. Arch Intern Med 1990; 150: 1881–4

    PubMed  Article  CAS  Google Scholar 

  19. 19.

    Kruse W, Eggert-Kruse W, Rampmaier J, et al. Dosage frequency and drug-compliance behavior — a comparative study on compliance with a medication to be taken twice or four times daily. Eur J Clin Pharmacol 1991; 41: 589–92

    PubMed  Article  CAS  Google Scholar 

  20. 20.

    Achong MR, Hauser BA, Krusky JL. Rational and irrational use of antibiotics in a Canadian teaching hospital. JAMA 1977; 116: 256–9

    CAS  Google Scholar 

  21. 21.

    McGowan Jr JE, Finland M. Usage of antibiotics in a general hospital: effect of requiring justification. J Infect Dis 1974; 130: 165–8

    PubMed  Article  Google Scholar 

  22. 22.

    Shapiro M, Townsend TR, Rosner B, et al. Use of antimicrobial drugs in general hospitals. N Engl J Med 1979; 301: 351–5

    PubMed  Article  CAS  Google Scholar 

  23. 23.

    Townsend TR, Shapiro M, Rosner B, et al. Use of antimicrobial drugs in general hospitals, I: description of population and definition of methods. J Infect Dis 1979; 139: 688–97

    PubMed  Article  CAS  Google Scholar 

  24. 24.

    Kunin CM, Tupasi T, Craig WA. Use of antibiotics: a brief exposition of the problem and some tentative solutions. Ann Intern Med 1973; 79: 555–60

    PubMed  CAS  Google Scholar 

  25. 25.

    Scheckler WE, Bennett JV. Antibiotic usage in seven community hospitals. JAMA 1970; 213: 264–7

    PubMed  Article  CAS  Google Scholar 

  26. 26.

    Dunagan WC, Woodward RS, Medoff G, et al. Antibiotic misuse in two clinical situations: positive blood culture and administration of aminoglycosides. Rev Infect Dis 1991; 13: 405–12

    PubMed  Article  CAS  Google Scholar 

  27. 27.

    Brody JA, Foley DJ. Epidemiologic considerations. In: Schneider EL, Wendland CJ, Zimmer AW, et al., editors. The teaching nursing home: a new approach to geriatric research, education, and clinical care. New York: Raven, 1990: 9–25

    Google Scholar 

  28. 28.

    Mott PD, Barker WH. Treatment decisions for infections occurring nursing home residents. J Am Geriatr Soc 1988; 36: 820–4

    PubMed  CAS  Google Scholar 

  29. 29.

    Zimmer JG, Bentley DW, Valenti WM, et al. Systemic antibiotic use in nursing homes a quality assessment. J Am Geriatr Soc 1986; 34: 703–10

    PubMed  CAS  Google Scholar 

  30. 30.

    Katz PR, Beam Jr TR, Brand F, et al. Antibiotic use in the nursing home. Arch Intern Med 1990; 150: 1465–8

    PubMed  Article  CAS  Google Scholar 

  31. 31.

    Warren JW, Palumbo FB, Fitterman L, et al. Incidence and characteristics of antibiotic use in aged nursing home patients. J Am Geriatr Soc 1991; 39: 963–72

    PubMed  CAS  Google Scholar 

  32. 32.

    Lee Y-L, Thrupp LD, Friis RH, et al. Nosocomial infections and antibiotic utilization in geriatric patients: a pilot prospective surveillance program in skilled nursing facilities. Gerontology 1992; 38: 223–32

    PubMed  Article  CAS  Google Scholar 

  33. 33.

    Pickering T-D, Gurwitz JH, Zaleznik D, et al. The appropriateness of oral fluoroquinolone-prescribing in the long-term care setting. J Am Geriatr Soc 1994; 42: 28–32

    PubMed  CAS  Google Scholar 

  34. 34.

    Kunin CM. Problems of antibiotic usage definitions, causes, and proposed solutions. Ann Intern Med 1978; 89: 802–5

    PubMed  CAS  Google Scholar 

  35. 35.

    Jones RN. The current and future impact of antimicrobial resistance among nosocomial bacterial pathogens. Diagn Microbiol Infect Dis 1992; 15: 3S–10S

    PubMed  CAS  Google Scholar 

  36. 36.

    Counts GW. Review and control of antimicrobial usage in hospitalized patients a recommended collaborative approach. JAMA 1977; 238: 2170–2

    PubMed  Article  CAS  Google Scholar 

  37. 37.

    Gurwitz J. The ambiguous relation between aging and adverse drug reactions. Ann Intern Med 1991; 114: 956–66

    PubMed  CAS  Google Scholar 

  38. 38.

    Schneider JK, Mion LC, Frengley JD. Adverse drug reactions in an elderly outpatient population. Am J Hosp Pharm 1992; 49: 90–6

    PubMed  CAS  Google Scholar 

  39. 39.

    Fong IW, Fenton RS, Bird R. Comparative toxicity of gentamicin versus tobramycin: a randomized prospective study. J Antimicrob Chemother 1981; 7: 81–8

    PubMed  Article  CAS  Google Scholar 

  40. 40.

    Eisenberg JM, Koffer H, Glick HA, et al. What is the cost of nephrotoxicity associated with aminoglycosides? Ann Intern Med 1987; 107: 900–9

    PubMed  CAS  Google Scholar 

  41. 41.

    Holmberg SD, Solomon SL, Blake PA. Health and economic impacts of antimicrobial resistance. Rev Infect Dis 1987; 9: 1065–78

    PubMed  Article  CAS  Google Scholar 

  42. 42.

    North D. Controlling the costs of antibiotic resistance. Clin Ther 1993; 15 (Suppl. A): 3–11

    PubMed  Google Scholar 

  43. 43.

    Yoshikawa TT. Unique aspects of infection in older adults. In: Yoshikawa TT, Norman DC, editors. Antimicrobial therapy for elderly patients. New York: Marcel Dekker, Inc., 1994: 1–7

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Thomas T. Yoshikawa.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rho, J.P., Yoshikawa, T.T. The Cost of Inappropriate Use of Anti-Infective Agents in Older Patients. Drugs & Aging 6, 263–267 (1995). https://doi.org/10.2165/00002512-199506040-00001

Download citation

Keywords

  • Nursing Home
  • Adverse Drug Reaction
  • Nursing Home Resident
  • Positive Blood Culture
  • Inappropriate Prescribe