Drugs & Aging

, Volume 6, Issue 4, pp 263–267 | Cite as

The Cost of Inappropriate Use of Anti-Infective Agents in Older Patients

  • Jay P. Rho
  • Thomas T. Yoshikawa
Leading Article

Keywords

Nursing Home Adverse Drug Reaction Nursing Home Resident Positive Blood Culture Inappropriate Prescribe 

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References

  1. 1.
    Yoshikawa TT. Antimicrobial therapy for the elderly patient. J Am Geriatr Soc 1990; 38: 1353–72PubMedGoogle Scholar
  2. 2.
    Yoshikawa TT, Norman DC. Antibiotic therapy: what to consider when treating geriatric patients. Hosp Formul 1993; 28: 754–68PubMedGoogle Scholar
  3. 3.
    Norman DC, Grahn D, Yoshikawa TT. Fever and aging. J Am Geriatr Soc 1985; 33: 859–63PubMedGoogle Scholar
  4. 4.
    Lindeman RD, Tobin J, Shock NW. Longitudinal studies on rate of decline in renal function with age. J Am Geriatr Soc 1985; 33: 278–85PubMedGoogle Scholar
  5. 5.
    McCue JD. Antibiotic dosing in renally impaired elderly. P & T 19: 349–62Google Scholar
  6. 6.
    Health Care Financing Administration Office of National Cost Estimates. National health expenditures, 1988. Health Care Financ Rev 1990; 11: 1–41Google Scholar
  7. 7.
    Ives TJ, Bentz EJ, Gwyther RE. Drug-related admissions to a family medicine inpatient service. Arch Intern Med 1987; 147: 1117–20PubMedCrossRefGoogle Scholar
  8. 8.
    Fincham JE. Adverse drug reaction occurrence in elderly patients. J Geriatr Drug Ther 1991; 5: 3–50Google Scholar
  9. 9.
    Grymonpre RE, Mitenko PA, Sitar DS, et al. Drug-associated hospital admissions in older medical patients. J Am Geriatr Soc 1988; 36: 1092–8PubMedGoogle Scholar
  10. 10.
    Lakshanan MC, Hershey CO, Breslau D. Hospital admissions caused by iatrogenic disease. Arch Intern Med 1986; 146: 1931–4CrossRefGoogle Scholar
  11. 11.
    Col N, Fanale JE, Kronholm P. The role of medication noncompliance and adverse drug reactions in hospitalizations of the elderly. Arch Intern Med 1990; 150: 841–5PubMedCrossRefGoogle Scholar
  12. 12.
    Colt HG, Shapiro AP. Drug-induced illness as a cause for admission to a community hospital. J Am Geriatr Soc 1989; 37: 323–6PubMedGoogle Scholar
  13. 13.
    Willcox SM, Himmelstein DU, Woolhandler S. Inappropriate drug prescribing for the community-dwelling elderly. JAMA 1994; 272: 292–315PubMedCrossRefGoogle Scholar
  14. 14.
    Beers MH, Ouslander JG, Fingold SF, et al. Inappropriate medication prescribing in skilled-nursing facilities. Ann Intern Med 1992; 117: 684–9PubMedGoogle Scholar
  15. 15.
    Beers MH, Ouslander JG, Rollingher I, et al. Explicit criteria for determining inappropriate medication use in nursing home residents. Arch Intern Med 1991; 151: 1825–32PubMedCrossRefGoogle Scholar
  16. 16.
    Cheung R, Sullens CM, Seal D, et al. The paradox of using a 7 day antibacterial course to treat urinary tract infections in the community. Br J Clin Pharmacol 1988; 26: 391–8PubMedCrossRefGoogle Scholar
  17. 17.
    Cramer JA, Mattson RH, Prevey ML, et al. How often is medication taken as prescribed? JAMA 1989; 261: 3273–7PubMedCrossRefGoogle Scholar
  18. 18.
    Eisen SA, Miller DK, Woodward RS, et al. The effect of prescribed daily dose frequency on patient medication compliance. Arch Intern Med 1990; 150: 1881–4PubMedCrossRefGoogle Scholar
  19. 19.
    Kruse W, Eggert-Kruse W, Rampmaier J, et al. Dosage frequency and drug-compliance behavior — a comparative study on compliance with a medication to be taken twice or four times daily. Eur J Clin Pharmacol 1991; 41: 589–92PubMedCrossRefGoogle Scholar
  20. 20.
    Achong MR, Hauser BA, Krusky JL. Rational and irrational use of antibiotics in a Canadian teaching hospital. JAMA 1977; 116: 256–9Google Scholar
  21. 21.
    McGowan Jr JE, Finland M. Usage of antibiotics in a general hospital: effect of requiring justification. J Infect Dis 1974; 130: 165–8PubMedCrossRefGoogle Scholar
  22. 22.
    Shapiro M, Townsend TR, Rosner B, et al. Use of antimicrobial drugs in general hospitals. N Engl J Med 1979; 301: 351–5PubMedCrossRefGoogle Scholar
  23. 23.
    Townsend TR, Shapiro M, Rosner B, et al. Use of antimicrobial drugs in general hospitals, I: description of population and definition of methods. J Infect Dis 1979; 139: 688–97PubMedCrossRefGoogle Scholar
  24. 24.
    Kunin CM, Tupasi T, Craig WA. Use of antibiotics: a brief exposition of the problem and some tentative solutions. Ann Intern Med 1973; 79: 555–60PubMedGoogle Scholar
  25. 25.
    Scheckler WE, Bennett JV. Antibiotic usage in seven community hospitals. JAMA 1970; 213: 264–7PubMedCrossRefGoogle Scholar
  26. 26.
    Dunagan WC, Woodward RS, Medoff G, et al. Antibiotic misuse in two clinical situations: positive blood culture and administration of aminoglycosides. Rev Infect Dis 1991; 13: 405–12PubMedCrossRefGoogle Scholar
  27. 27.
    Brody JA, Foley DJ. Epidemiologic considerations. In: Schneider EL, Wendland CJ, Zimmer AW, et al., editors. The teaching nursing home: a new approach to geriatric research, education, and clinical care. New York: Raven, 1990: 9–25Google Scholar
  28. 28.
    Mott PD, Barker WH. Treatment decisions for infections occurring nursing home residents. J Am Geriatr Soc 1988; 36: 820–4PubMedGoogle Scholar
  29. 29.
    Zimmer JG, Bentley DW, Valenti WM, et al. Systemic antibiotic use in nursing homes a quality assessment. J Am Geriatr Soc 1986; 34: 703–10PubMedGoogle Scholar
  30. 30.
    Katz PR, Beam Jr TR, Brand F, et al. Antibiotic use in the nursing home. Arch Intern Med 1990; 150: 1465–8PubMedCrossRefGoogle Scholar
  31. 31.
    Warren JW, Palumbo FB, Fitterman L, et al. Incidence and characteristics of antibiotic use in aged nursing home patients. J Am Geriatr Soc 1991; 39: 963–72PubMedGoogle Scholar
  32. 32.
    Lee Y-L, Thrupp LD, Friis RH, et al. Nosocomial infections and antibiotic utilization in geriatric patients: a pilot prospective surveillance program in skilled nursing facilities. Gerontology 1992; 38: 223–32PubMedCrossRefGoogle Scholar
  33. 33.
    Pickering T-D, Gurwitz JH, Zaleznik D, et al. The appropriateness of oral fluoroquinolone-prescribing in the long-term care setting. J Am Geriatr Soc 1994; 42: 28–32PubMedGoogle Scholar
  34. 34.
    Kunin CM. Problems of antibiotic usage definitions, causes, and proposed solutions. Ann Intern Med 1978; 89: 802–5PubMedGoogle Scholar
  35. 35.
    Jones RN. The current and future impact of antimicrobial resistance among nosocomial bacterial pathogens. Diagn Microbiol Infect Dis 1992; 15: 3S–10SPubMedGoogle Scholar
  36. 36.
    Counts GW. Review and control of antimicrobial usage in hospitalized patients a recommended collaborative approach. JAMA 1977; 238: 2170–2PubMedCrossRefGoogle Scholar
  37. 37.
    Gurwitz J. The ambiguous relation between aging and adverse drug reactions. Ann Intern Med 1991; 114: 956–66PubMedGoogle Scholar
  38. 38.
    Schneider JK, Mion LC, Frengley JD. Adverse drug reactions in an elderly outpatient population. Am J Hosp Pharm 1992; 49: 90–6PubMedGoogle Scholar
  39. 39.
    Fong IW, Fenton RS, Bird R. Comparative toxicity of gentamicin versus tobramycin: a randomized prospective study. J Antimicrob Chemother 1981; 7: 81–8PubMedCrossRefGoogle Scholar
  40. 40.
    Eisenberg JM, Koffer H, Glick HA, et al. What is the cost of nephrotoxicity associated with aminoglycosides? Ann Intern Med 1987; 107: 900–9PubMedGoogle Scholar
  41. 41.
    Holmberg SD, Solomon SL, Blake PA. Health and economic impacts of antimicrobial resistance. Rev Infect Dis 1987; 9: 1065–78PubMedCrossRefGoogle Scholar
  42. 42.
    North D. Controlling the costs of antibiotic resistance. Clin Ther 1993; 15 (Suppl. A): 3–11PubMedGoogle Scholar
  43. 43.
    Yoshikawa TT. Unique aspects of infection in older adults. In: Yoshikawa TT, Norman DC, editors. Antimicrobial therapy for elderly patients. New York: Marcel Dekker, Inc., 1994: 1–7Google Scholar

Copyright information

© Adis International Limited 1995

Authors and Affiliations

  • Jay P. Rho
    • 1
  • Thomas T. Yoshikawa
    • 2
    • 3
  1. 1.Department of Clinical PharmacyUniversity of Southern California School of PharmacyLos AngelesUSA
  2. 2.Office of Geriatrics and Extended CareUnited States Department of Veterans AffairsUSA
  3. 3.Department of Healthcare SciencesGeorge Washington University School of MedicineUSA

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