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Drug Safety

, Volume 26, Issue 6, pp 381–403 | Cite as

Benefits and Risks of Pharmacological Smoking Cessation Therapies in Chronic Obstructive Pulmonary Disease

  • Edwin J. Wagen
  • Maurice P.A. Zeegers
  • Constant P. van Schayck
  • Emiel F.M. Wouters
Review Article

Abstract

Smoking cessation is the most effective way to reduce the risk of developing chronic obstructive pulmonary disease (COPD) or to reduce its progression. However, little is known about the efficacy and safety of different pharmacological smoking cessation therapies used for the treatment of patients with COPD who smoke. The aim of this review was to evaluate the benefits and risks of pharmacological smoking cessation therapies in COPD. We conducted an extensive computer-aided literature search which resulted in the identification of four papers that met the inclusion criteria and contributed to this review.

In two studies the efficacy of nicotine polacrilex (nicotine gum) was assessed. In one study, which did not have a control group, the efficacy of nicotine nasal spray was evaluated. The fourth study, a placebo-controlled trial, evaluated the efficacy of bupropion sustained release. The results of these studies indicated that nicotine gum, nicotine nasal spray and bupropion have a good safety profile and seem to increase abstinence rates in smokers with COPD. The incidence and nature of specific adverse effects occurring in patients with COPD seem to be comparable with the adverse effects reported by healthy smokers. However, the efficacy seems to depend on the follow-up period used to define success (i.e. abstinence rates decline with longer follow-up), as well as the intensity and duration of the concomitant psychosocial intervention.

This review indicates that for a continuation of the effect of pharmacological smoking cessation therapies, the combination of pharmacotherapy (to reduce craving and withdrawal) and a relapse-prevention programme, in which attention is focused on the behavioural aspects of smoking and smoking cessation, seems to increase abstinence, especially when the psychosocial intervention is prolonged for a longer period. Also, the characteristics of the smokers who are motivated to quit must be taken into account in order to increase the number of successful attempts to quit smoking and prevent relapses. We therefore recommend using a holistic approach in which the possible coexistence of multiple problems (which are known to affect the success of smoking cessation strategies) is integrated.

Keywords

Chronic Obstructive Pulmonary Disease Nicotine Smoking Cessation Bupropion Nicotine Replacement Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The work presented in this paper was supported by the Dutch Asthma Foundation (NAF grant no. 3.2.00.21) and the Health Research and Development Council (ZorgOnderzoek Nederland grant no. 2200.0111), The Netherlands. The authors have no (potential) conflict of interest, which is or might be relevant to the contents of this manuscript.

References

  1. 1.
    Sethi JM, Rochester CL. Smoking and chronic obstructive pulmonary disease. Clin Chest Med 2000; 21(1): 67–86, viiiPubMedCrossRefGoogle Scholar
  2. 2.
    US Surgeon General. The health consequences of smoking: chronic obstructive lung disease. Report no.: DHHS 84–50205. Washington (DC): US Department of Health and Human Services; 1984Google Scholar
  3. 3.
    Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001; 163(5): 1256–76PubMedGoogle Scholar
  4. 4.
    Murray CJL, Lopez AD. Mortality by cause for eight regions of the world: global burden of disease study. Lancet 1997; 349: 1269–76PubMedCrossRefGoogle Scholar
  5. 5.
    Barnes PJ. Chronic obstructive pulmonary disease. N Engl J Med 2000; 343(4): 269–80PubMedCrossRefGoogle Scholar
  6. 6.
    Murray CJL, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study. Lancet 1997; 349: 1498–504PubMedCrossRefGoogle Scholar
  7. 7.
    Anthonisen NR, Connett JE, Kiley JP, et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1: The Lung Health Study. JAMA 1994; 272(19): 1497–505PubMedCrossRefGoogle Scholar
  8. 8.
    Xu X, Dockery DW, Ware JH, et al. Effects of cigarette smoking on rate of loss of pulmonary function in adults: a longitudinal assessment. Am Rev Respir Dis 1992; 146: 1345–8PubMedGoogle Scholar
  9. 9.
    Coleman T. Smoking cessation: integrating recent advances into clinical practice. Thorax 2001; 56: 579–82PubMedCrossRefGoogle Scholar
  10. 10.
    Lancaster T, Stead L, Silagy C, et al. Effectiveness of interventions to help people stop smoking: findings from the Cochrane Library. BMJ 2000; 321(7257): 355–8PubMedCrossRefGoogle Scholar
  11. 11.
    Wagena EJ, Huibers MJ, van Schayck CP. Antidepressants in the treatment of patients with COPD: possible associations between smoking cigarettes, COPD and depression. Thorax 2001; 56(8): 587–8PubMedCrossRefGoogle Scholar
  12. 12.
    Mannino DM. COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. Chest 2002; 121: 121S–6SPubMedCrossRefGoogle Scholar
  13. 13.
    American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995; 152: S77–121Google Scholar
  14. 14.
    Medical Research Council. Definition and classification of chronic bronchitis for clinical and epidemiological purposes: a report to the Medical Research Council by their committee on the etiology of chronic bronchitis. Lancet 1965; I: 775–9Google Scholar
  15. 15.
    Fletcher C, Pride NB. Definitions of emphysema, chronic bronchitis, asthma, and airflow obstruction: 25 years on from the Ciba symposium. Thorax 1984; 39: 81–5PubMedCrossRefGoogle Scholar
  16. 16.
    Roche N, Huchon GJ. Current issues in the management of chronic obstructive pulmonary disease. Respirology 1997; 2: 215–29PubMedCrossRefGoogle Scholar
  17. 17.
    US Department of Health and Human Services. The health consequences of smoking: chronic obstructive lung disease. Report No. (CDC) 8.416. Rockville (MD): Office on Smoking and Health, Department of Health and Human Services; 1984Google Scholar
  18. 18.
    Fletcher C, Peto R. The natural history of chronic airflow obstruction. BMJ 1977; 1(6077): 1645–8PubMedCrossRefGoogle Scholar
  19. 19.
    Withey CH, Papacosta AO, Swan AV, et al. Respiratory effects of lowering tar and nicotine levels of cigarettes smoked by young male middle tar smokers: II. results of a randomised controlled trial. J Epidemiol Community Health 1992; 46: 281–5PubMedCrossRefGoogle Scholar
  20. 20.
    Fletcher CM, Peto R, Tinker CM, Speizer FE. The natural history of chronic bronchitis and emphysema. Oxford: Oxford University Press, 1976Google Scholar
  21. 21.
    Benowitz NL, Hall SM, Herning RI, et al. Smokers of low-yield cigarettes do not consume less nicotine. N Engl J Med 1983; 309(3): 139–42PubMedCrossRefGoogle Scholar
  22. 22.
    Herning RI, Jones RT, Benowitz NL, et al. How a cigarette is smoked determines blood nicotine levels. Clin Pharmacol Ther 1983; 33(1): 84–90PubMedCrossRefGoogle Scholar
  23. 23.
    Lange P, Groth S, Nyboe J, et al. Decline of the lung function related to the type of tobacco smoked and inhalation. Thorax 1990; 45: 22–6PubMedCrossRefGoogle Scholar
  24. 24.
    Burchfiel C, Marcus E, Curb J, et al. Effects of smoking and smoking cessation on longitudinal decline in pulmonary function. Am J Respir Crit Care Med 1995; 151(6): 1778–85PubMedGoogle Scholar
  25. 25.
    Camilli AE, Burrows B, Knudson RJ, et al. Longitudinal changes in forced expiratory volume in one second in adults. Am Rev Respir Dis 1987; 135: 794–9PubMedGoogle Scholar
  26. 26.
    Muers MF. Quitting smoking and lungs. Lancet 1999; 354: 177–8PubMedCrossRefGoogle Scholar
  27. 27.
    Pelkonen M, Notkola I-L, Tukiainen H, et al. Smoking cessation, decline in pulmonary function and total mortality: a 30 year follow up study among the Finnish cohorts of the Seven Countries Study. Thorax 2001; 56(9): 703–7PubMedCrossRefGoogle Scholar
  28. 28.
    Tashkin DP, Detels R, Simmons M, et al. The UCLA population studies of chronic obstructive respiratory disease: XI. impact of air pollution and smoking on annual change in forced expiratory volume in one second. Am J Respir Crit Care Med 1994; 149: 1209–17PubMedGoogle Scholar
  29. 29.
    Tager IB, Segal MR, Speizer FE, et al. The natural history of forced expiratory volumes: effect of cigarette smoking and respiratory symptoms. Am Rev Respir Dis 1988; 138: 837–49PubMedCrossRefGoogle Scholar
  30. 30.
    Sherrill D, Holberg C, Enright P, et al. Longitudinal analysis of the effects of smoking onset and cessation on pulmonary function. Am J Respir Crit Care Med 1994; 149(3): 591–7PubMedGoogle Scholar
  31. 31.
    Soejima K, Yamaguchi K, Kohda E, et al. Longitudinal follow-up study of smoking-induced lung density changes by high resolution computed tomography. Am J Respir Crit Care Med 2000; 161: 1264–73PubMedGoogle Scholar
  32. 32.
    Burrows B, Knudson RJ, Cline MG, et al. Quantitative relationships between cigarette smoking and ventilatory function. Am Rev Respir Dis 1979; 115: 195–205Google Scholar
  33. 33.
    Medici TC, Unger S, Ruegger M. Smoking pattern of smokers with and without tobacco-smoke-related lung diseases. Am Rev Respir Dis 1985; 131: 385–8PubMedGoogle Scholar
  34. 34.
    O’Donnell D. Ventilatory limitations in chronic obstructive pulmonary disease. Med Sci Sports Exerc 2001; 33(7): S647–55PubMedGoogle Scholar
  35. 35.
    Palmes ED, Altshuler B, Nelson N. Deposition of aerosols in the human respiratory tract during breath holding. Oxford: Pergamon, 1966Google Scholar
  36. 36.
    Killen JD, Fortmann SP, Kraemer HC, et al. Who will relapse? Symptoms of nicotine dependence predict long-term relapse after smoking cessation. J Consult Clin Psychol 1992; 60(5): 797–801PubMedCrossRefGoogle Scholar
  37. 37.
    Jiménez-Ruiz CA, Masa F, Miravitlles M, et al. Smoking characteristics: differences in attitudes and dependence between healthy smokers and smokers with COPD. Chest 2001; 119(5): 1365–70PubMedCrossRefGoogle Scholar
  38. 38.
    Heatherton TF, Kozlowski LT, Frecker RC, et al. The Fagerström test for nicotine dependence: a revision of the Fagerström tolerance questionnaire. Br J Addict 1991; 86: 1119–27PubMedCrossRefGoogle Scholar
  39. 39.
    Breslau N, Johnson EO. Predicting smoking cessation and major depression in nicotine-dependent smokers. Am J Public Health 2000; 90(7): 1122–7PubMedCrossRefGoogle Scholar
  40. 40.
    Killen JD, Fortmann SP, Kraemer HC, et al. Interactive effects of depression symptoms, nicotine dependence, and weight change on late smoking relapse. J Consult Clin Psychol 1996; 64(5): 1060–7PubMedCrossRefGoogle Scholar
  41. 41.
    Breslau N, Peterson EL, Schultz LR, et al. Major depression and stages of smoking: a longitudinal investigation. Arch Gen Psychiatry 1998; 55(2): 161–6PubMedCrossRefGoogle Scholar
  42. 42.
    Covey LS, Glassman AH, Stetner F. Cigarette smoking and major depression. J Addict Dis 1998; 17(1): 35–46PubMedCrossRefGoogle Scholar
  43. 43.
    Glassman AH, Helzer JE, Covey LS, et al. Smoking, smoking cessation, and major depression. JAMA 1990; 264(12): 1546–9PubMedCrossRefGoogle Scholar
  44. 44.
    Glassman AH, Covey LS, Stetner F, et al. Smoking cessation and the course of major depression: a follow-up study. Lancet 2001; 357: 1929–32PubMedCrossRefGoogle Scholar
  45. 45.
    Glassman AH, Stetner F, Walsh BT, et al. Heavy smokers, smoking cessation, and clonidine: results of a double-blind, randomized trial. JAMA 1988; 259(19): 2863–6PubMedCrossRefGoogle Scholar
  46. 46.
    van Manen JG, Bindels PJ, Ijzermans CJ, et al. Prevalence of comorbidity in patients with a chronic airway obstruction and controls over the age of 40. J Clin Epidemiol 2001; 54(3): 287–93PubMedCrossRefGoogle Scholar
  47. 47.
    van Manen JG, Bindels PJ, Dekker FW, et al. Risk of depression in patients with chronic obstructive pulmonary disease and its determinants. Thorax 2002; 57: 412–6PubMedCrossRefGoogle Scholar
  48. 48.
    Peveler R, Carson A, Rodin G. ABC of psychological medicine: depression in medical patients. BMJ 2002; 325: 149–52PubMedCrossRefGoogle Scholar
  49. 49.
    McKinney B. COPD and depression: treat them both. RN 1994; 57(4): 48–50PubMedGoogle Scholar
  50. 50.
    Borson S, McDonald GJ, Gayle T, et al. Improvement in mood, physical symptoms, and function with nortriptyline for depression in patients with chronic obstructive pulmonary disease. Psychosomatics 1992; 33(2): 190–201PubMedCrossRefGoogle Scholar
  51. 51.
    Humerfelt S, Eide GE, Kvale G, et al. Effectiveness of postal smoking cessation advice: a randomised controlled trial in young men with reduced FEV1 and asbestos exposure. Eur Respir J 1998; 11: 284–90PubMedCrossRefGoogle Scholar
  52. 52.
    Walters N, Coleman T. Comparison of the smoking behaviour and attitudes of smokers who attribute respiratory symptoms to smoking with those who do not. Br J Gen Pract 2002; 52: 132–4PubMedGoogle Scholar
  53. 53.
    Brandt CJ, Ellegaard H, Joensen MB, et al. Effect of diagnosis of ‘smoker’s lung’ [letter]. Lancet 1997; 349: 253PubMedCrossRefGoogle Scholar
  54. 54.
    Ayanian JZ, Cleary PD. Perceived risks of heart disease and cancer among cigarette smokers. JAMA 1999; 281(11): 1019–21PubMedCrossRefGoogle Scholar
  55. 55.
    Gibbons FX, Eggleston TJ, Benthin AC. Cognitive reactions to smoking relapse: the reciprocal relation between dissonance and self-esteem. J Pers Soc Psychol 1997; 72(1): 184–95PubMedCrossRefGoogle Scholar
  56. 56.
    Halpern MT. Effect of smoking characteristics on cognitive dissonance in current and former smokers. Addict Behav 1994; 19(2): 209–17PubMedCrossRefGoogle Scholar
  57. 57.
    Rigotti NA. Treatment of tobacco use and dependence. N Engl J Med 2002; 346(7): 506–12PubMedCrossRefGoogle Scholar
  58. 58.
    Emmons KM. Smoking cessation and tobacco control. Chest 1999; 116: 490S–2SPubMedCrossRefGoogle Scholar
  59. 59.
    Moxham J. Nicotine addiction. BMJ 2000; 320(7232): 391–2PubMedCrossRefGoogle Scholar
  60. 60.
    Benowitz NL, Henningfield JE. Establishing a nicotine threshold for addiction: the implications for tobacco regulations. N Engl J Med 1994; 331(2): 123–5PubMedCrossRefGoogle Scholar
  61. 61.
    Department of Health and Human Services, Public Health Service. The health consequences of smoking: nicotine addiction: a report of the Surgeon General. Report no.: DHHS publication no. (CDC) 88–8406. Washington (DC): Government Printing Office; 1988Google Scholar
  62. 62.
    Diagnostic and statistical manual of mental disorders. 4th ed. DSM-IV. Washington (DC): American Psychiatric Association, 1994Google Scholar
  63. 63.
    Henningfield JE. Drug therapy: nicotine medications for smoking cessation. N Engl J Med 1995; 333: 1196–203PubMedCrossRefGoogle Scholar
  64. 64.
    Bancroft A, Wiltshire S, Parry O, Amos A. It’s like an addiction first thing, afterwards it’s like a habit: daily smoking behaviour among people living in areas of deprivation. Soc Sci Med. In pressGoogle Scholar
  65. 65.
    Balfour DJK, Ridley DL. The effects of nicotine on neural pathways implicated in depression: a factor in nicotine addiction? Pharmacol Biochem Behav 2000; 66(1): 79–85PubMedCrossRefGoogle Scholar
  66. 66.
    Breslau N, Johnson EO, Hiripi E, et al. Nicotine dependence in the United States: prevalence, trends and smoking persistence. Arch Gen Psychiatry 2001; 58: 810–16PubMedCrossRefGoogle Scholar
  67. 67.
    Breslau N, Kilbey MM, Andreski P. Nicotine dependence and major depression: new evidence from a prospective investigation. Arch Gen Psychiatry 1993; 50(1): 31–5PubMedCrossRefGoogle Scholar
  68. 68.
    Covey LS. Tobacco cessation among patients with depression. Prim Care 1999; 26(3): 691–706PubMedCrossRefGoogle Scholar
  69. 69.
    Markou A, Kosten TR, Koob GF. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology 1998; 18(3): 135–74PubMedCrossRefGoogle Scholar
  70. 70.
    Kendler KS, Neale MC, MacLean CJ, et al. Smoking and major depression: a causal analysis. Arch Gen Psychiatry 1993; 50(1): 36–43PubMedCrossRefGoogle Scholar
  71. 71.
    Manheimer E, Anderson D. Survey of public information about ongoing clinical trials funded by industry: evaluation of completeness and accessibility. BMJ 2002; 325: 528–31PubMedCrossRefGoogle Scholar
  72. 72.
    McCray AT. Better access to information about clinical trials. Ann Intern Med 2000; 133: 609–14PubMedGoogle Scholar
  73. 73.
    Anderson D, Costa I, Dickersin K. TrialsCentral, an online register of clinical trials registers. Control Clin Trials 2001; 22: 40–1SGoogle Scholar
  74. 74.
    BTS guidelines for the management of chronic obstructive pulmonary disease: The COPD Guideline Group of the Standards of Care Committee of the BTS. Thorax 1997; 52 Suppl. 5: S1–28Google Scholar
  75. 75.
    Siafakas NM, Vermeire P, Pride NB, et al. Optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force. Eur Respir J 1995; 8(8): 1398–420PubMedCrossRefGoogle Scholar
  76. 76.
    Sachs DPL, Benowitz NL, Silver KJ. Effective use of nicotine polacrilex (Nicorette®) in patients with chronic obstructive pulmonary disease. In: Aoki M, et al., editors. Smoking and health. Amsterdam: Elsevier, 1987: 793–5Google Scholar
  77. 77.
    Glover ED, Glover PN, Abrons HL, et al. Smoking cessation among COPD and chronic bronchitis patients using the nicotine nasal spray. Am J Health Behav 1997; 21(4): 310–7Google Scholar
  78. 78.
    Tashkin DP, Kanner R, Bailey W, et al. Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebo-controlled, randomised trial. Lancet 2001; 357(9268): 1571–5PubMedCrossRefGoogle Scholar
  79. 79.
    Zevin S, Gourlay SG, Benowitz NL. Clinical pharmacology of nicotine. Clin Dermatol 1998; 16: 557–64PubMedCrossRefGoogle Scholar
  80. 80.
    Dempsey DA, Benowitz NL. Risks and benefits of nicotine to aid smoking cessation in pregnancy. Drug Saf 2001; 24(4): 277–322PubMedCrossRefGoogle Scholar
  81. 81.
    Benowitz NL. Nicotine replacement therapy: what has been accomplished: can we do better? Drugs 1993; 45(2): 157–70PubMedCrossRefGoogle Scholar
  82. 82.
    Ferry LH. Non-nicotine pharmacotherapy for smoking cessation. Prim Care 1999; 26(3): 653–69PubMedCrossRefGoogle Scholar
  83. 83.
    Gourlay SG, Benowitz NL. The benefits of stopping smoking and the role of nicotine replacement therapy in older patients. Drugs Aging 1996; 9(1): 8–23PubMedCrossRefGoogle Scholar
  84. 84.
    Okuyemi KS, Ahluwalia JS, Harris KJ. Pharmacotherapy of smoking cessation. Arch Fam Med 2000; 9(3): 270–81PubMedCrossRefGoogle Scholar
  85. 85.
    Balfour DJK, Fagerström K. Pharmacology of nicotine and its therapeutic use in smoking cessation and neurodegenerative disorders. Pharmacol Ther 1996; 72(1): 51–81PubMedCrossRefGoogle Scholar
  86. 86.
    Hughes JR, Goldstein MG, Hurt RD, et al. Recent advances in the pharmacotherapy of smoking. JAMA 1999; 281(1): 72–6PubMedCrossRefGoogle Scholar
  87. 87.
    Connett JE, Kusek JW, Bailey WC, et al. Design of the Lung Health Study: a randomized clinical trial of early intervention for chronic obstructive pulmonary disease. Control Clin Trials 1993; 14: 3S–19SPubMedCrossRefGoogle Scholar
  88. 88.
    Buist AS, Connett JE, Miller RD, et al. Chronic obstructive pulmonary disease early intervention trial (Lung Health Study): baseline characteristics of randomized participants. Chest 1993; 103(6): 1863–72PubMedCrossRefGoogle Scholar
  89. 89.
    O’Hara P, Grill J, Rigdon MA, et al. Design and results of the initial intervention program for the Lung Health Study. Prev Med 1993; 22(3): 304–15PubMedCrossRefGoogle Scholar
  90. 90.
    Murray RP, Bailey WC, Daniels K, et al. Safety of nicotine polacrilex gum used by 3094 participants in the Lung Health Study. Chest 1996; 109: 438–45PubMedCrossRefGoogle Scholar
  91. 91.
    Jarvis MJ, Powell SR, Marsh HS, et al. A meta-analysis of clinical studies confirms the effectiveness of bupropion SR (Zyban™) in smoking cessation. Poster presentation at the 8th Annual Meeting of the Society for Research on Nicotine and Tobacco; 2002 Feb 20-23; Savannah (GA)Google Scholar
  92. 92.
    Benowitz NL. Pharmacodynamics of nicotine: implications for rational treatment and addiction. Br J Addict 1991; 86: 495–9PubMedCrossRefGoogle Scholar
  93. 93.
    Schneider NG, Lunell E, Olmstead RE, et al. Clinical pharmacokinetics of nasal nicotine delivery: a review and comparison to other nicotine systems. Clin Pharmacokinet 1996; 31(1): 65–80PubMedCrossRefGoogle Scholar
  94. 94.
    Sutherland G, Stapleton JA, Russell MA, et al. Randomised controlled trial of nasal nicotine spray in smoking cessation. Lancet 1992; 340(8815): 324–9PubMedCrossRefGoogle Scholar
  95. 95.
    Covey LS, Sullivan MA, Johnston JA, et al. Advances in non-nicotine pharmacotherapy for smoking cessation. Drugs 2000; 59(1): 17–31PubMedCrossRefGoogle Scholar
  96. 96.
    Holm KJ, Spencer CM. Bupropion: a review of its use in the management of smoking cessation. Drugs 2000; 59(4): 1007–24PubMedCrossRefGoogle Scholar
  97. 97.
    Lerman C, Roth D, Kaufmann V, et al. Mediating mechanisms for the impact of bupropion in smoking cessation treatment. Drug Alcohol Depend 2002; 67: 219–23PubMedCrossRefGoogle Scholar
  98. 98.
    Glaxo Wellcome. Bupropion hydrochloride sustained-release tablets prescribing information. Research Triangle Park (NC): Glaxo Wellcome, 1999Google Scholar
  99. 99.
    Wagena EJ, de Graaf L, Chavannes NH, et al. Unrest about safety of bupropion as an aid to smoking cessation unwarranted [in Dutch]. Ned Tijdschr Geneeskd 2001; 145(31): 1489–92PubMedGoogle Scholar
  100. 100.
    Kelso P. Smoking pill link to 35 deaths. The Guardian 2001; Apr 26Google Scholar
  101. 101.
    Finch J. Safety agency clears Zyban. The Guardian 2002; Jul 27Google Scholar
  102. 102.
    Silagy C, Lancaster T, Stead L, et al. Nicotine replacement therapy for smoking cessation (Cochrane Review). Available in The Cochrane Library [database on disk and CD ROM]. Updated quarterly. The Cochrane Collaboration; issue 2. Oxford: Update Software, 2002Google Scholar
  103. 103.
    Fiore MC, Bailey WC, Cohen SJ. Treating tobacco use and dependence: clinical practice guideline. Rockville (MD): US Department of Health and Human Services, Public Health Service, 2000 JunGoogle Scholar
  104. 104.
    Lancaster T, Stead LF. Individual behavioural counselling for smoking cessation (Cochrane Review). Available in The Cochrane Library [database on disk and CD ROM]. Updated quarterly. The Cochrane Collaboration; issue 2. Oxford: Update Software, 2002Google Scholar
  105. 105.
    Stead LF, Lancaster T. Group behaviour therapy for smoking cessation. Available in The Cochrane Library [database on disk and CD ROM]. Updated quarterly. The Cochrane Collaboration; issue 2. Oxford: Update Software, 2002Google Scholar
  106. 106.
    Zimmerman M, Mattia JL, Posternak MA. Are subjects in pharmacological treatment trials of depression representative of patients in routine clinical practice? Am J Psychiatry 2002; 159(3): 469–73PubMedCrossRefGoogle Scholar
  107. 107.
    Silagy C, Formica N. Place of bupropion in smoking-cessation therapy [letter]. Lancet 2001; 357: 1550PubMedCrossRefGoogle Scholar
  108. 108.
    Hughes JR. Rigidity in measures of smoking cessation. Addiction 2002; 97: 795–800CrossRefGoogle Scholar
  109. 109.
    Velicer WF, Prochaska JO, Rossi JS, et al. Assessing outcome in smoking cessation studies. Psychol Bull 1992; 111(1): 23–41PubMedCrossRefGoogle Scholar
  110. 110.
    Ferry LH, Burchette RJ. Efficacy of bupropion for smoking cessation in non depressed smokers [abstract]. J Addict Dis 1994; 13(4): 249Google Scholar
  111. 111.
    Hurt RD, Sachs DP, Glover ED, et al. A comparison of sustained-release bupropion and placebo for smoking cessation. N Engl J Med 1997; 337(17): 1195–202PubMedCrossRefGoogle Scholar
  112. 112.
    Jorenby DE, Leischow SJ, Nides MA, et al. A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. N Engl J Med 1999; 340(9): 685–91PubMedCrossRefGoogle Scholar
  113. 113.
    Hays JT, Hurt RD, Rigotti NA, et al. Sustained-release bupropion for pharmacologic relapse prevention after smoking cessation: a randomized, controlled trial. Ann Intern Med 2001; 135(6): 423–33PubMedGoogle Scholar
  114. 114.
    Tonstad S, Aaserud E, Hjalmarson A, et al. Zyban is an effective and well-tolerated aid to smoking cessation in a general smoking population: a multicountry study [abstract]. 3rd European Conference of the Society for Research on Nicotine and Tobacco; 2001, ParisGoogle Scholar
  115. 115.
    Zellweger JP, Blaziene A, Astbury C, et al. Bupropion hydrochloride sustained release (SR) is an effective and well tolerated aid to smoking cessation in a healthcare professionals population: a multi-country study [abstract]. Eur Respir J 2001; 18Suppl. 33: 166sGoogle Scholar
  116. 116.
    Puska PMJ, Brath H, Astbury C, et al. Zyban is an effective and well tolerated aid to smoking cessation in a healthcare professionals population: a multi-country study [abstract]. 3rd European Conference of the Society for Research on Nicotine and Tobacco; 2001, ParisGoogle Scholar
  117. 117.
    George TP, Vessicchio JC, Termine A, et al. A placebo controlled trial of bupropion for smoking cessation in schizophrenia. Biol Psychiatry 2002; 52: 53–61PubMedCrossRefGoogle Scholar
  118. 118.
    Weiner E, Ball MP, Summerfelt A, et al. Effects of sustained-release pion and supportive group therapy on cigarette consumption in patients with schizophrenia. Am J Psychiatry 2001; 158: 635–7PubMedCrossRefGoogle Scholar
  119. 119.
    Evins AE, Mays VK, Rigotti NA, et al. A pilot trial of bupropion added to cognitive behavioral therapy for smoking cessation in schizophrenia. Nicotine Tob Res 2001; 3: 397–403PubMedCrossRefGoogle Scholar
  120. 120.
    Chengappa KN, Kambhampati RK, Perkins K, et al. Bupropion sustained release as a smoking cessation treatment in remitted depressed patients maintained on treatment with selective serotonin reuptake inhibitor antidepressants. J Clin Psychiatry 2001; 62(7): 503–8PubMedCrossRefGoogle Scholar
  121. 121.
    Hertzberg MA, Moore SD, Feldman ME, et al. A preliminary study of bupropion sustained-release for smoking cessation in patients with chronic post-traumatic stress disorder. J Clin Psychopharmacol 2001; 21: 94–8PubMedCrossRefGoogle Scholar
  122. 122.
    McRobbie H, Aaserud E, Lefrandt JD, et al. Zyban is an effective and well tolerated aid to smoking cessation in smokers with cardiovascular disease: an international study [abstract]. 3rd European Conference of the Society for Research on Nicotine and Tobacco; 2001, ParisGoogle Scholar
  123. 123.
    Gonzales DH, Nides MA, Ferry LH, et al. Bupropion SR as an aid to smoking cessation in smokers treated previously with bupropion: a randomized placebo-controlled study. Clin Pharmacol Ther 2001; 69: 438–44PubMedCrossRefGoogle Scholar
  124. 124.
    Selby P, Brosky G, Baker R, et al. Zyban is effective in the retreatment of relapsed adult smokers [abstract]. 3rd European Conference of the Society for Research on Nicotine and Tobacco; 2001, ParisGoogle Scholar
  125. 125.
    Hughes JR, Stead LF, Lancaster T. Antidepressants for smoking cessation (Cochrane Review). Available in The Cochrane Library [database on disk and CD ROM]. Updated quarterly. The Cochrane Collaboration; issue 2. Oxford: Update Software, 2002Google Scholar
  126. 126.
    Cox A, Anton C. Safety profile for chronic obstructive pulmonary disease [letter]. Lancet 2001; 358: 1010PubMedCrossRefGoogle Scholar
  127. 127.
    Eypasch E, Lefering R, Kum CK, et al. Probability of adverse events that have not yet occurred: a statistical reminder. BMJ 1995; 311: 619–20PubMedCrossRefGoogle Scholar
  128. 128.
    García-Río F, Serrano S, Mediano O, et al. Safety profile of bupropion for chronic obstructive pulmonary disease. Lancet 2001; 358: 1009PubMedCrossRefGoogle Scholar
  129. 129.
    Tashkin DP, Jamerson BD, Patel MJ. Safety profile of bupropion hydrochloride for chronic obstructive pulmonary disease. Lancet 2001; 358: 1009–10CrossRefGoogle Scholar
  130. 130.
    Robinson TE, Berridge KC. The psychology and neurobiology of addiction: an incentive-sensitization view. Addiction 2000; 95Suppl. 2: S91–S117PubMedGoogle Scholar
  131. 131.
    Silagy C, Mant D, Fowler G, et al. Meta-analysis on efficacy of nicotine replacement therapies in smoking cessation. Lancet 1994; 343(8890): 139–42PubMedCrossRefGoogle Scholar
  132. 132.
    Tang JL, Law M, Wald N. How effective is nicotine replacement therapy in helping people to stop smoking? BMJ 1994; 308(6920): 21–6PubMedCrossRefGoogle Scholar
  133. 133.
    Fiore MC, Smith SS, Jorenby DE, et al. The effectiveness of the nicotine patch for smoking cessation: a meta-analysis. JAMA 1994; 271(24): 1940–7PubMedCrossRefGoogle Scholar
  134. 134.
    Young R, Glennon RA. Nicotine and bupropion share a similar discriminative stimulus effect. Eur J Pharmacol 2002; 443: 113–8PubMedCrossRefGoogle Scholar
  135. 135.
    Johnston JA, Ascher J, Leadbetter R, et al. Pharmacokinetic optimisation of sustained-release bupropion for smoking cessation. Drugs 2002; 62Suppl. 2: 11–24PubMedCrossRefGoogle Scholar
  136. 136.
    Epping Jordan MP, Watkins SS, Koob GF, et al. Dramatic decreases in brain reward function during nicotine withdrawal. Nature 1998; 393(6680): 76–9PubMedCrossRefGoogle Scholar
  137. 137.
    Durcan MJ, Deener G, White JD, et al. The effect of bupropion sustained-release on cigarette craving after smoking cessation. Clin Ther 2002; 24(4): 540–51PubMedCrossRefGoogle Scholar
  138. 138.
    Hughes JR. Distinguishing nicotine dependence from smoking: why it matters to tobacco control and psychiatry. Arch Gen Psychiatry 2001; 58: 817–8PubMedCrossRefGoogle Scholar

Copyright information

© Adis Data Information BV 2003

Authors and Affiliations

  • Edwin J. Wagen
    • 1
  • Maurice P.A. Zeegers
    • 2
  • Constant P. van Schayck
    • 1
  • Emiel F.M. Wouters
    • 3
  1. 1.Department of General Practice, Research Institute for Extramural and Transmural Health Care (ExTra)Maastricht UniversityMaastrichtThe Netherlands
  2. 2.Department of EpidemiologyMaastricht UniversityMaastrichtThe Netherlands
  3. 3.Department of Respiratory MedicineUniversity Hospital MaastrichtMaastrichtThe Netherlands

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