Abstract
Drug interactions are a common and serious problem arising from polypharmacy. Strategies to reduce the likelihood of the co-prescription of hazardous drug combinations are likely to enhance the quality of care provided for patients requiring polypharmacotherapy. Drugs for which patient-oriented information strategies may decrease the likelihood of drug interactions tend to be those of low therapeutic index, and have interaction potential with other drugs commonly prescribed or available without prescription.
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References
Strand LM, Morley PC, Cipolle RJ, et al. Drug-related problems: their structure and function. DICP Ann Pharmacother 1999; 24: 1093–7
Stanton LA, Peterson GM, Rumble RH, et al. Drug-related admissions to an Australian hospital. J Clin Pharm Ther 1994; 19: 341–7
Mok H, Mulpeter K, O’Connor P. Drug-drug interactions in the hospital. Ir Med J 1991; 84: 26
Jankel CA, Fitterman LK. Epidemiology of drug-drug interactions as a cause of hospital admissions. Drug Saf 1993; 9: 51–9
Goldberg RM, Mabee J, Chan L, et al. Drug-drug and drug-disease interactions in the ED: analysis of a high-risk population. Am J Emerg Med 1996; 14: 447–50
Costa AJ. Potential drug interactions in an ambulatory geriatric population. Fam Pract 1991; 8: 234–6
Cadieux RJ. Drug interactions in the elderly. How multiple drug use increases risk exponentially. Postgrad Med 1989; 86: 179–86
Marik PE, Fromm L. A case series of hospitalized patients with elevated digoxin levels. Am J Med 1998; 105: 110–5
Hamilton RA, Gordon T. Incidence and cost of hospital admissions secondary to drug interactions involving theophylline. Ann Pharmacother 1992; 26: 1507–11
Jankel CA, McMillan JA, Martin BA. Effect of drug interactions on outcome of patients receiving warfarin or theophylline. Am J Hosp Pharm 1994; 51: 661–6
Atkin PA, Stringer RS, Duffy JB, et al. The influence of information provided by patients in the accuracy of medication records. Med J Aust 1998; 169: 85–8
Atkin PA, Finnegan TP, Ogle SJ, et al. Are medication cards useful? Med J Aust 1995; 162: 300–1
Sansom LN, editor. Australian pharmaceutical formulary and handbook. 16th ed. Canberra, Australia: Pharmaceutical Society of Australia, 1997
Duguid MJ. CPI - education or information? Aust J Hosp Pharm 1994; 24: 229
Joseph P. Consumer product information affects us all: IV - medical practitioner view. Aust Prescr 1996; 19: 33–4
Fogg S. Consumer product information affects us all: II - consumer view. Aust Presc 1996; 19: 32
Baker SJ. Who can read consumer product information? Aust J Hosp Pharm 1997; 27: 126–31
Davidson J, Zung WW, Walker JI. Practical aspects of MAO inhibitor therapy. J Clin Psychiatry 1984; 45: 81–4
Scalley RD, Kearney E, Jakobs E. Interdisciplinary inpatient warfarin education program. Am J Hosp Pharm 1979; 36: 219–20
Walker JI. Use of a patient education booklet to improve compliance with lithium therapy [letter]. Psychosomatics 1981; 22: 51
Alderman CP. Medication alert cards to minimise antidepressant drug interactions. Aust J Hosp Pharm 1998; 28: 259–60
Lacro JP, Jeste DV. Physical comorbidity and polypharmacy in older psychiatric patients. Biol Psychiatry 1994; 36: 146–52
Nemeroff CB, DeVane CL, Pollock BG. Newer antidepressants and the cytochrome p450 system. Am J Psychiatry 1996; 153: 311–20
Adson DE, Crow SJ, Meller WH, et al. Potential drug interactions on a tertiary-care hospital consultation-liaison psychiatry service. Psychosomatics 1998; 39: 360–5
McClung HJ, Murray RD, Heitlinger LA. The internet as a source of current patient information. Pediatrics 1998; 101: E2
Dowe MC, Lawrence PA, Carlson J, et al. Patients’ use of health teaching materials at three readability levels. Appl Nurs Res 1997; 10: 86–93
Monk D. Who can read consumer product information [letter]. Aust J Hosp Pharm 1997; 27: 250–1
Tasker J, Parker S, Friedel H, et al. Who can read consumer product information [letter]. Aust J Hosp Pharm 1997; 27: 251–2
Sless D. Who can read consumer product information [letter]. Aust J Hosp Pharm 1997; 27: 252–3
Baker S. Who can read consumer product information [letter]. Aust J Hosp Pharm 1997; 27: 253–4
Lasater L, Mehler PS. The illiterate patient: screening and management. Hosp Pract 1998; 33: 169–70
Fogarty JS. Reactance theory and patient noncompliance. Soc Sci Med 1997; 45: 1277–88
Feste C, Anderson RM. Empowerment: from philosophy to practice. Patient Educ Couns 1995; 26: 139–44
Chaplin R, Kent A. Informing patients about tardive dyskinesia. Controlled trial of patient education. Br J Psychiatry 1998; 172: 78–81
Arthur VA. Written patient information: a review of the literature. J Adv Nurs 1995; 21: 1081–6
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This work was supported in part by financial grants from the Medical Benefits Fund (MBF) of Australia, and the Special Purposes Trust Fund of the Repatriation General Hospital, Daw Park, South Australia.
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Alderman, C.P. Patient-Oriented Strategies for the Prevention of Drug Interactions. Drug-Safety 22, 103–109 (2000). https://doi.org/10.2165/00002018-200022020-00003
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DOI: https://doi.org/10.2165/00002018-200022020-00003