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Drug Safety

, Volume 17, Issue 1, pp 8–36 | Cite as

Adverse Effects of Class I Antiarrhythmic Drugs

  • Jacques Caron
  • Christian Libersa
Review Articles Drug Experience

Summary

Class I antiarrhythmic drugs are characterised by their ability to block the fast inward sodium current in cardiac muscle tissue. However, at the same time, they can be responsible for various effects involving other organs and systems. Although some of these effects can be helpful in specific situations, most of them, such as their pro-arrhythmic propensity, are deleterious.

Some of the adverse effects of class I antiarrhythmic drugs are directly linked to sodium-channel blockade (conduction disorders, haemodynamic perturbations, and digestive and neurological effects), while others are linked to other specific pharmacological properties (e.g. atropinic, or α- or β-adrenergic blockade) or to nonspecific properties (idiosyncratic hypersensitivity, and haematological, dermatological or hepatic reactions).

Other adverse effects are associated with complex interactions between class I antiarrhythmics and individual predisposing factors, trigger mechanisms and physiological factors (including concomitant drug treatment). These numerous variations and interactions within a specific environment and underlying disorder might be of pharmacological or/and pharmacokinetic origin, making analysis of the true liability of the class I drugs very difficult when adverse effects occur.

Keywords

Quinidine Antiarrhythmic Drug Disopyramide Flecainide Procainamide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis International Limited 1997

Authors and Affiliations

  • Jacques Caron
    • 1
  • Christian Libersa
    • 2
    • 3
  1. 1.Centre Régional de Pharmacovigilance, Service de Pharmacologie Hospitalière, Faculté de MédecineUniversité Droit et SantéLilleFrance
  2. 2.Unité de Pharmacologie Clinique, Service de Pharmacologie Hospitalière, Faculté de MédecineUniversité Droit et SantéLilleFrance
  3. 3.Clinical Investigation Center CH&U — INSERMHôpital CardiologiqueLilleFrance

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