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Drug Safety

, Volume 12, Issue 2, pp 110–119 | Cite as

Tenoxicam and Renal Function

  • Roland C. A. Heintz
Review Article Drug Experience

Summary

The association of some nonsteroidal anti-inflammatory drugs (NSAIDs) with adverse effects on renal function has led to the need to systematically determine the risk of clinically relevant renal effects in patients treated with these drugs. Tenoxicam, an NSAID with established efficacy in the treatment of rheumatic diseases, has been studied in a variety of patient populations to evaluate its effects on renal function.

Investigational studies, up to 5 years’ duration, evaluated glomerular filtration rate, renal blood flow and tubular function. There was no evidence of clinically relevant renal toxicity in patients with normal renal function, in elderly patients with age-related renal function, or in patients with mild to moderate renal impairment. There was, however, one patient with pre-existing renal pathology, who experienced raised plasma creatinine after 5 years of treatment. These findings are supported by an analysis of urinary system adverse effects in clinical trials that included over 67 000 patients, 25% of whom were elderly. The prevalence of these events, 0.07%, was similar in patients in both age groups. The most common events were dysuria and renal pain.

Thus, patients treated long term with tenoxicam are at low risk for nephrotoxic effects. It is not recommended, however, that patients with severe pre-existing renal insufficiency receive tenoxicam.

Keywords

Glomerular Filtration Rate Piroxicam Sulindac Tenoxicam Renal Plasma Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis International Limited 1995

Authors and Affiliations

  • Roland C. A. Heintz
    • 1
    • 2
  1. 1.Faculty of PharmacyUniversity Louis PasteurStrasbourgFrance
  2. 2.Faculty of PharmacyF. Hoffmann-La Roche LtdBaselSwitzerland

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