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Photosensitivity Associated with Antibacterial Agents

  • Review Article
  • Drug Experience
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Summary

Skin reactions following the interaction of photoactive drugs and ultraviolet or visible radiation are usually rapidly reversible after drug cessation. Within the antibacterial group, photosensitivity to sulphonamides, nalidixic acid, fluoroquinolones and tetracycline members have all been reported.

In general such reactions are mild, although rarely some individuals have a severe response. Precise subcellular mechanisms are drug specific, appear complex, and as yet are ill understood. Measures such as drug dosage reduction, the wearing of photoprotective clothing and use of broad spectrum sunscreens can alleviate the problem.

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References

  • Bjellerup M. Tetracycline phototoxicity: an experimental and clinical study, Thesis, Malmo University, 1986

  • Bilsland D, Douglas WS. Sunbed pseudoporphyria induced by nalidixic acid. British Journal of Dermatology 123: 547, 1990

    Article  PubMed  CAS  Google Scholar 

  • Bowie WR, Willetts V, Jewesson PJ. Adverse reactions in a dose-ranging study with a new long-acting fluoroquinolone, fleroxacin. Antimicrobial Agents and Chemotherapy 33: 1778–1782, 1989

    Article  PubMed  CAS  Google Scholar 

  • Burry JN, Crosby RWL. A case of phototoxicity to nalidixic acid. Medical Journal of Australia 2: 698, 1966

    PubMed  CAS  Google Scholar 

  • Epstein JH, Tuffanelli DL, Seibert JS, Epstein WL. Porphyria-like cutaneous changes induced by tetracycline hydrochloride photosensitization. Archives of Dermatology 112: 661–666, 1976

    Article  PubMed  CAS  Google Scholar 

  • Epstein S. Photoallergy and primary phototoxicity to sulfanilamide. Journal of Investigative Dermatology 2: 43–51, 1939

    Article  CAS  Google Scholar 

  • Ferguson J, Johnson BE. Ciprofloxacin-induced photosensitivity: in vitro and in vivo studies. British Journal of Dermatology 123: 9–20, 1990

    Article  PubMed  CAS  Google Scholar 

  • Ferguson J, Johnson BE. Clinical and laboratory studies of the photosensitizing potential of norfloxacin, a 4-quinoline broad-spectrum antibiotic. British Journal of Dermatology 128: 285–295, 1993

    Article  PubMed  CAS  Google Scholar 

  • Ferguson J, Addo HA, McGill PE, Woodcock KR, Johnson BE, et al. A study of benoxaprofen-induced photosensitivity. British Journal of Dermatology 107: 429–442, 1982

    Article  PubMed  CAS  Google Scholar 

  • Frain-Bell W. A study of persistent photosensitivity as a sequel of the prior administration of the drug benoxaprofen. British Journal of Dermatology 121: 551–562, 1989

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez JP, Henwood JM. Pefloxacin: a review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 37: 628–668, 1989

    Article  PubMed  CAS  Google Scholar 

  • Henderson CA, Cunliffe WJ. Unusual side-effects in patients receiving doxycycline. Journal of Dermatological Treatment 1: 95–96,1989

    Article  Google Scholar 

  • Izu R, Gardeazabal J, Gonzalez M, Landa N, Raton JA, et al. Enoxacin-induced photosensitivity: study of two cases. Photodermatology Photoimmunology Photomedicine 9: 86–88, 1992

    CAS  Google Scholar 

  • Jensen T, Pedersen SS, Nielsen CH, Hoiby N, Koch C. The efficacy and safety of ciprofloxacin and ofloxacin in chronic Pseudomonas aeruginosa infection in cystic fibrosis. Journal of Antimicrobial Chemotherapy 20: 585–594, 1987

    Article  PubMed  CAS  Google Scholar 

  • Johnson BE, Ferguson J. Drug and chemical photosensitivity. Seminars in Dermatology 9: 39–46, 1990

    PubMed  CAS  Google Scholar 

  • Johnson BE, Walker EM, Hetherington AM. In vitro models for cutaneous phototoxicity. In Marks & Plewig (Eds) Skin models, models to study function and disease of skin, pp. 264–281, Springer-Verlag, Berlin, 1986

    Google Scholar 

  • Johnson BE, Walker EM, Ferguson J. Quinoline-induced photosensitivity. Reviews of Infectious Diseases 11(Suppl. 5): S1396–S1397, 1989

    Google Scholar 

  • Layton AM, Cunliffe WJ. Phototsensitive eruptions to doxycycline — a dose related phenomenon. British Journal of Dermatology 127(Suppl. 40): 31, 1992

    Google Scholar 

  • Nielsen OH. Sulphasalazine intolerance: retrospective survey of the reasons for discontinuing treatment with sulphasalazine in patients with chronic inflammatory bowel disease. Scandinavian Journal of Gastroenterology 17: 389–393, 1982

    Article  PubMed  CAS  Google Scholar 

  • Okada N, Moriya K, Nishida K, Kitano Y, Kobayashi T, et al. Skin pigmentation associated with minocycline therapy. British Journal of Dermatology 121: 247–254, 1989

    Article  PubMed  CAS  Google Scholar 

  • Orentreich N, Harber LC, Tromovitch TA. Photosensitivity and photo-onycholysis due to demethylchlortetracycline. Archives of Dermatology 83: 730–737, 1961

    Article  PubMed  CAS  Google Scholar 

  • Parent M, St Laurent M, LeBel M. Safety of fleroxacin coadministered with theophylline to young and elderly volunteers. Antimicrobial Agents and Chemotherapy 34: 1249–1253, 1990

    Article  PubMed  CAS  Google Scholar 

  • Peterkin GAG. Sulphonamide rashes: an analysis of 500 cases seen in North Africa and Italy. British Medical Journal 2:4409–4414,1945

    Article  Google Scholar 

  • Phillips G, Johnson BE, Ferguson J. The loss of antibiotic activity of ciprofloxacin by photodegradation. Journal of Antimicrobial Chemotherapy 26: 783–789, 1990

    Article  PubMed  CAS  Google Scholar 

  • Ramsay CA, Obreshkova E. Photosensitivity from nalidixic acid. British Journal of Dermatology 91: 523–528, 1974

    Article  PubMed  CAS  Google Scholar 

  • Zuehlke RL. Papular doxycycline photosensitivity. Archives of Dermatology 108: 837–838, 1973

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Consultant in Dermatology, Photobiology Unit, Department of Dermatology, Ninewells Hospital and Medical School, Dundee, DDI 9SY, Scotland

    Nicholas J. Wainwright, Paul Collins &  James Ferguson

Authors
  1. Nicholas J. Wainwright
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  2. Paul Collins
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  3. James Ferguson
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Wainwright, N.J., Collins, P. & Ferguson, J. Photosensitivity Associated with Antibacterial Agents. Drug-Safety 9, 437–440 (1993). https://doi.org/10.2165/00002018-199309060-00006

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  • DOI: https://doi.org/10.2165/00002018-199309060-00006

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