Drug-induced sexual dysfunction is well known to occur with antihypertensive drugs in men. There are much less data on the effects of drugs on female sexual function.
The physiology of the female sexual response has similarities to that of the male sexual response and there are therefore good reasons for suspecting that antihypertensive drugs are likely to adversely affect sexual function in women. Present evidence suggests that clonidine, methyldopa, guanethidine and reserpine are associated with adverse effects on sexual function. In healthy volunteers, labetalol appears to reduce vaginal lubrication, but there are no studies in patients receiving the drug therapeutically. Thiazide diuretics may be associated with the worsening of sexual problems, which interestingly appear to be ameliorated by weight reduction. Present evidence on the effects of vasodilators is limited but the evidence suggests that sexual function in women receiving calcium antagonists is not altered by changing to an angiotensin converting enzyme (ACE) inhibitor.
Although present evidence suggests that effects on female sexual function may not be very great, it should be recognised that there are very few data in this area. Further work is clearly necessary.
Sexual Function Antihypertensive Drug Sexual Dysfunction Labetalol Sexual Problem
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Riley AJ, Riley EJ. The effect of labetalol and propranolol on the pressor response to sexual arousal in women. British Journal of Clinical Pharmacology 12: 341–344, 1981PubMedCrossRefGoogle Scholar
Schoenberger JA, Testa M, Ross AD, Brennan WK, Bannon JA. Efficacy, safety, and quality-of-life assessment of captopril antihypertensive therapy in clinical practice. Archives of Internal Medicine 150: 301–306, 1990PubMedCrossRefGoogle Scholar
Semmens JP, Semmens FJ. Inadequate vaginal lubrication. Medical Aspects of Human Sexuality 12: 58–71, 1978Google Scholar
Smith PJ, Talbert RL. Sexual dysfunction with antihypertensives and antipsychotic agents. Clinical Pharmacy 5: 373–384, 1986PubMedGoogle Scholar
Spark RF, Melby JC. Aldosteronism in hypertension. Annals of Internal Medicine 69: 685–691, 1968PubMedGoogle Scholar
Stevenson JG, Umstead GS. Sexual dysfunction due to antihypertensive agents. Drug Intelligence and Clinical Pharmacy 18: 113–121, 1984PubMedGoogle Scholar
Wartman SA. Sexual side effects of antihypertensive drugs: treatment strategies and strictures. Postgraduate Medicine 73: 133–138, 1983PubMedGoogle Scholar
Wassertheil-Smoller S, Blanfox MD, Oberman A, Davis BR, Swencionis C, et al. Effect of antihypertensives on sexual function and quality of life: the TAIM Study. Annals of Internal Medicine 114: 613–620, 1991PubMedGoogle Scholar
Wein AJ, Van Arsdalen KN. Drug-induced male sexual dysfunction. Urologic Clinics of North America 15: 23–31, 1988PubMedGoogle Scholar
Weinberger MH. Lowering blood pressure in patients without affecting quality of life. American Journal of Medicine 86 (Suppl. 1B): 94–97, 1989PubMedCrossRefGoogle Scholar