Drug Safety

, Volume 7, Issue 1, pp 3–7 | Cite as

Activated Charcoal in the Treatment of Drug Overdose

An Update
  • Wesley Palatnick
  • Milton Tenenbein
Leading Article

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References

  1. Albertson TE, Derlet RW, Foulke GE, Inguillon ML, Tharratt SR. Superiority of activated charcoal alone compared with ipecac and activated charcoal in the treatment of acute toxic ingestions. Annals of Emergency Medicine 18: 56–59, 1989PubMedCrossRefGoogle Scholar
  2. Benson B, Van Antwerp M, Hergott T. A fatality resulting from multiple dose activated charcoal therapy. Veterinary and Human Toxicology 31: 335, 1989Google Scholar
  3. Berg MJ, Berlinger WG, Goldberg MJ, Spector R, Johnston GF. Acceleration of body clearance of phenobarbital by oral activated charcoal. New England Journal of Medicine 307: 642–644, 1982PubMedCrossRefGoogle Scholar
  4. Berlinger WG, Spector R, Goldberg MJ, Johnson GE, Que CK, et al. Enhancement of theophylline clearance by oral activated charcoal. Clinical Pharmacology and Therapeutics 33: 351–354, 1983PubMedCrossRefGoogle Scholar
  5. Brent J, Kulig K, Rumack BH. Iatrogenic death from sorbitol and magnesium sulfate during treatment for salicylism. Veterinary and Human Toxicology 31: 334, 1989Google Scholar
  6. Caldwell JW, Nava AJ, De Haas DD. Hypernatremia associated with cathartics in overdose management. Western Journal of Medicine 147: 593–5 96, 1987PubMedGoogle Scholar
  7. Cooney DO. Activated charcoal. Antidotal and other medicinal uses. Marcel Dekker, New York, 1980Google Scholar
  8. Curtis RA, Barone J, Giacona N. Efficacy of ipecac and activated charcoal/cathartic: prevention of salicylate absorption in a simulated overdose. Archives of Internal Medicine 144: 48–52, 1984PubMedCrossRefGoogle Scholar
  9. Deriet RW, Albertson TE. Activated charcoal — past, present and future. Western Journal of Medicine 145: 493–496, 1986Google Scholar
  10. Easom JM, Caraccio TR, Lovejoy Jr FH. Evaluation of activated charcoal and magnesium citrate in the prevention of aspirin absorption in humans. Clinical Pharmacy 1: 154–156, 1982PubMedGoogle Scholar
  11. Farley TA. Severe hypernatremic dehydration after use of activated charcoal-sorbitol suspension. Journal of Pediatrics 109: 719–722, 1986PubMedCrossRefGoogle Scholar
  12. Goldberg MJ, Park GD, Spector R, Fischer LJ, Feldman RD. Lack of effect of oral activated charcoal on imipramine clearance. Clinical Pharmacology and Therapeutics 38: 350–353,1985PubMedCrossRefGoogle Scholar
  13. Goldberg MJ, Spector R, Park GD, Roberts RJ. An approach to the management of the poisoned patient. Archives of Internal Medicine 146: 1381–1385, 1986PubMedCrossRefGoogle Scholar
  14. Harsch HH. Aspiration of activated charcoal. New England Journal of Medicine 314: 318, 1986PubMedGoogle Scholar
  15. Ho JL, Tierney Mg, Dickinson GE. An evaluation of the effect of repeated doses of activated charcoal on salicylate elimination. Journal of Clinical Pharmacology 29: 366–369, 1989PubMedGoogle Scholar
  16. Jones J, Heiselman D, Dougherty J, Eddy E. Cathartic induced magnesium toxicity during overdose management. Annals of Emergency Medicine 15: 1214–1218, 1986PubMedCrossRefGoogle Scholar
  17. Jones J, McMullen MJ, Dougherty J, Cannon L. Repetitive doses of activated charcoal in the treatment of poisoning. American Journal of Emergency Medicine 5: 305–310, 1987PubMedGoogle Scholar
  18. Katona BG, Siegel EG, Cluxton Jr RJ. The new black magic: activated charcoal and new therapeutic uses. Journal of Emergency Medicine 5: 9–18, 1987PubMedCrossRefGoogle Scholar
  19. Keller RE, Schwab RA, Krenzelok EP. Contribution of sorbitol combined with activated charcoal in prevention of salicylate absorption. Annals of Emergency Medicine 19: 654–656, 1990PubMedCrossRefGoogle Scholar
  20. Kirshenbaum LA, Mathews SC, Sitar DS, Tenenbein M. Does multiple-dose charcoal therapy enhance salicylate excretion? Archives of Interval Medicine 150: 1281–1283, 1990aCrossRefGoogle Scholar
  21. Kirshenbaum LA, Sitar DS, Tenenbein M. Interaction between whole bowel irrigation solution and activated charcoal: implications for the treatment of toxic ingestions. Annals of Emergency Medicine 19: 1129–1132, 1990bPubMedCrossRefGoogle Scholar
  22. Krenzelok EP, Keller R, Stewart RD. Gastrointestinal transit times of cathartics combined with charcoal. Annals of Emergency Medicine 14: 1152–1155, 1985PubMedCrossRefGoogle Scholar
  23. Kulig K, Bar-Or D, Cantrill SV, Rosen P, Rumack BH. Management of acutely poisoned patients without gastric emptying. Annals of Emergency Medicine 14: 562–567, 1985PubMedCrossRefGoogle Scholar
  24. Lalonde RL, Deshpande R, Hamilton PP, McLean WM, Greenway DC. Acceleration of digoxin clearance by activated charcoal. Clinical Pharmacology and Therapeutics 37: 367–371, 1985PubMedCrossRefGoogle Scholar
  25. Levy G. Gastrointestinal clearance of drugs with activated charcoal. New England Journal of Medicine 307: 676–678, 1982PubMedCrossRefGoogle Scholar
  26. Levy G, Tsuchiya T. Effect of activated charcoal on aspirin absorption in man. Clinical Pharmacology and Therapeutics 13: 317–322, 1972PubMedGoogle Scholar
  27. Mauro LS, Mauro VF, Brown DL, Somani P. Enhancement of phenytoin elimination by multiple-dose activated charcoal. Annals of Emergency Medicine 16: 1132–1135, 1987PubMedCrossRefGoogle Scholar
  28. Mayersohn M, Perrier D, Picchioni AL. Evaluation of charcoal mixture as an antidote for oral aspirin overdose. Clinical Toxicology 11: 561–567, 1977PubMedCrossRefGoogle Scholar
  29. McCord MM, Okun AL. Toxicity of sorbitol-charcoal suspension. Journal of Pediatrics 111: 307–308, 1987Google Scholar
  30. McNamara R, Aaron CK, Gemborys M, Davidheiser S. Sorbitol catharsis does not enhance efficacy of charcoal in a simulated acetaminophen overdose. Annals of Emergency Medicine 17: 243–246, 1988PubMedCrossRefGoogle Scholar
  31. Menzies DG, Busuttil A, Precott LF. Fatal pulmonary aspiration of activated charcoal. British Medical Journal 297: 459–460, 1988PubMedCrossRefGoogle Scholar
  32. Merigian KS, Woodard M, Hedges Jr, Stuebing R, Rashkin MC. Prospective evaluation of gastric emptying in the self poisoned patient. American Journal of Emergency Medicine 8: 479–483, 1990PubMedCrossRefGoogle Scholar
  33. Neuvonen PJ. Clinical pharmacokinetics or oral activated charcoal in acute intoxications. Clinical Pharmacokinetics 7: 465–489, 1982PubMedCrossRefGoogle Scholar
  34. Neuvonen PJ, Elonen E. Effect of activated charcoal on absorption and elimination of phenobarbitone, carbamazepine and phenylbutazone in man. European Journal of Clinical Pharmacology 17: 51–57, 1980PubMedCrossRefGoogle Scholar
  35. Neuvonen PJ, Olkkola KT. Effect of purgatives on antidotal efficacy of oral activated charcoal. Human Toxicology 5: 255–263, 1986PubMedCrossRefGoogle Scholar
  36. Neuvonen PJ, Olkkola KT. Oral activated charcoal in the treatment of intoxications: role of single and repeated doses. Medical Toxicology 3: 33–58, 1988PubMedGoogle Scholar
  37. Park GD, Goldberg MJ, Spector R, Johnson GF, Feldman RD, et al. The effects of activated charcoal on digoxin and digitoxin clearance. Drug Intelligence and Clinical Pharmacy 19: 937–941, 1985PubMedGoogle Scholar
  38. Park GD, Spector R, Goldberg MJ, Johnson GF. Expanded role of charcoal therapy in the poisoned and overdosed patient. Archives of Internal Medicine 146: 969–973, 1986PubMedCrossRefGoogle Scholar
  39. Picchioni AL. Activated charcoal: a neglected antidote. Pediatric clinics of North America 17: 535–543, 1870Google Scholar
  40. Pond SM. Role of repeated oral doses of activated charcoal in clinical toxicology. Medical Toxicology 1: 341, 1986Google Scholar
  41. Pond SM, Olson KR, Osterloh JD, Tong TG. Randomized study of the treatment of phenobarbital overdose with repeated doses of activated charcoal. Journal of the American Medical Association 251: 3104–3108, 1984PubMedCrossRefGoogle Scholar
  42. Rau NR, Nagaraj MV, Prakash PS, Nelli P. Fatal pulmonary aspiration of activated charcoal. British Medical Journal 297: 918–919, 1988Google Scholar
  43. Ray MJ, Padin R., Condie JD, Halls JM. Charcoal bezoar: small bowel obstruction secondary to amitriptyline overdose therapy. Digestive Diseases and Sciences 33: 106–107, 1988PubMedCrossRefGoogle Scholar
  44. Riegel JM, Becker CE. Use of cathartics in toxic ingestions. Annals of Emergency Medicine 10: 254–258, 1981PubMedCrossRefGoogle Scholar
  45. Saetta JP, March S, Gaunt ME, Quinton DN. Gastric emptying procedures in the self-poisoned patient: are we forcing gastric content beyond the pylorus? Journal of the Royal Society of Medicine 84: 274–276, 1991PubMedGoogle Scholar
  46. Saetta JP, Quinton DN. Residual gastric content after gastric lavage and ipecacuanha-induced emesis in self-poisoned patients: An endoscopic study. Journal of the Royal Society of Medicine 84: 35–38, 1991PubMedGoogle Scholar
  47. Sessler CN. Poor tolerance of oral activated charcoal with theophylline overdose. American Journal of Emergency Medicine 5: 492–495, 1987PubMedCrossRefGoogle Scholar
  48. Sessler CN. Glauser FL, Cooper KR. Treatment of theophylline toxicity with oral activated charcoal. Chest 87: 325–329, 1985PubMedCrossRefGoogle Scholar
  49. Shannon M, Fish SS, Lovejoy Jr FH. Cathartics and laxatives: do they still have a place in management of the poisoned patient? Medical Toxicology 1: 247–252, 1986PubMedGoogle Scholar
  50. Sketris IS, Mowry JB, Czajka PA, Anderson WH, Stafford DT. saline catharsis: effect on aspiration bioavailability in combination with activated charcoal. Journal of Clinical Pharmacology 22: 59–64, 1982PubMedGoogle Scholar
  51. Tenenbein M. Inefficacy of gastric emptying procedures. Journal of Emergency Medicine 3: 133–136, 1985PubMedCrossRefGoogle Scholar
  52. Tenenbein M. Whole bowel irrigation in iron poisoning. Journal of Pediatrics 111: 142–145, 1987PubMedCrossRefGoogle Scholar
  53. Tenenbein M. Whole bowel irrigation as a gastrointestinal decontamination procedure after acute poisoning. Medical Toxicology 3: 77–84, 1988PubMedGoogle Scholar
  54. Tenenbein M. Multiple doses of activated charcoal — time for reappraisal? Annals of Emergency Medicine 20: 529–531, 1991PubMedCrossRefGoogle Scholar
  55. Tenenbein M, Cohen Sitar DS. Efficacy of ipecac-induced emesis, orogastric lavage and activated charcoal for acute drug overdose. Annals of Emergency Medicine 16: 838–841, 1987PubMedCrossRefGoogle Scholar
  56. Watson WA, Cremer KF, Chapman JA. Gastrointestinal obstruction associated with multiple activated charcoal. Journal of Emergency Medicine 4: 401–407, 1986PubMedCrossRefGoogle Scholar

Copyright information

© Adis International Limited 1992

Authors and Affiliations

  • Wesley Palatnick
    • 1
  • Milton Tenenbein
    • 1
  1. 1.Department of Family Medicine and Department of Pediatrics, PharmacologyUniversity of Manitoba, and the Manitoba Poison Control CentreWinnipegCanada

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