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Drugs & Aging

, Volume 29, Issue 2, pp 133–142 | Cite as

RETRACTED ARTICLE: Three-year Experience with Alendronate Treatment in Postmenopausal Osteoporotic Japanese Women with or without Renal Dysfunction

A Retrospective Study
  • Jun IwamotoEmail author
  • Yoshihiro Sato
  • Mitsuyoshi Uzawa
  • Tsuyoshi Takeda
  • Hideo Matsumoto
Original Research Article

Abstract

Background and Objective: Chronic kidney disease is associated with an increased risk of fragility fractures. A retrospective study was conducted to compare outcomes after 3 years of alendronate treatment in postmenopausal osteoporotic Japanese women with or without renal dysfunction (RD).

Methods: One hundred and thirty-five postmenopausal osteoporotic Japanese women (mean age at baseline: 68 years) who had been treated with alendronate in our outpatient clinic for more than 3 years were analysed. The lumbar spine bone mineral density (BMD) of patients was measured using dual energy x-ray absorptiometry, and urinary levels of cross-linked N-terminal telopeptides of type I collagen (NTX) and serum levels of alkaline phosphatase (ALP) were monitored during the 3-year treatment period. The incidence of osteoporotic fractures was also assessed.

Results: Twenty-six women had RD with an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m2. The urinary NTX and serum ALP levels significantly decreased and the lumbar spine BMD significantly increased, compared with the baseline values, in a manner that was similar among women with or without RD. However, the incidence of non-vertebral fractures, but not that of vertebral fractures, was significantly higher among women with RD than among women without RD.

Conclusions: Alendronate treatment appeared to have a similar effect on surrogate markers in postmenopausal osteoporotic Japanese women with or without RD. However, further studies are needed to confirm that RD may increase the risk of non-vertebral fractures in patients treated with alendronate.

Keywords

Bone Mineral Density Vertebral Fracture Renal Dysfunction Alendronate Lumbar Spine Bone Mineral Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The authors report no funding sources or conflict of interest in this work.

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Copyright information

© Adis Data Information BV 2012

Authors and Affiliations

  • Jun Iwamoto
    • 1
    Email author
  • Yoshihiro Sato
    • 2
  • Mitsuyoshi Uzawa
    • 3
  • Tsuyoshi Takeda
    • 1
  • Hideo Matsumoto
    • 1
  1. 1.Institute for Integrated Sports MedicineKeio University School of MedicineShinjuku-ku, TokyoJapan
  2. 2.Department of NeurologyMitate HospitalFukuokaJapan
  3. 3.Department of Orthopaedic SurgeryKeiyu Orthopaedic HospitalGunmaJapan

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