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HLA-Associations in Leponex®/Clozaril® (Clozapine)-Induced Granulocytopenia and Agranulocytosis

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Summary

This paper describes a statistical analysis of the simultaneous occurrence of 48 human leucocyte antigens (HLAs) in an attempt to predict whether a patient treated with clozapine will develop granulocytopenia or agranulocytosis. Whereas the numerical results show that use of HLAs does not appear to satisfy the intended purpose, emphasis is placed on the statistical methodology recommended for a problem of this type. Other work in this area is critically discussed.

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Authors and Affiliations

  1. Department of Biomathematics, Universitätsklinikum, Theodor Stern Kai 7, D-W-6000, Frankfurt am Main 70, Federal Republic of Germany

    K. Abt

  2. Clinical Research Department, Sandoz Pharma Ltd, Basle, Switzerland

    A. Gülich, P. Krupp & W. Reinberg

Authors
  1. K. Abt
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  2. A. Gülich
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  3. P. Krupp
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  4. W. Reinberg
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Abt, K., Gülich, A., Krupp, P. et al. HLA-Associations in Leponex®/Clozaril® (Clozapine)-Induced Granulocytopenia and Agranulocytosis. Drug-Safety 7 (Suppl 1), 10–16 (1992). https://doi.org/10.2165/00002018-199200071-00006

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  • DOI: https://doi.org/10.2165/00002018-199200071-00006

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