A Journey in Science: Cell-Cycle Control
Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to document and preserve these histories. The monographs recount the seminal events as told in the voice of the original investigators who provided the crucial early insight. These essays capture the essence of discovery, chronicling the birth of ideas that created new fields of research; and launched trajectories that persisted and ultimately influenced how disease is prevented, diagnosed, and treated. In this volume, the Cerami Award Monograph is by Paul Nurse, Director, The Francis Crick Institute in London, UK. A visionary in the field of cell biology, this is the story of Dr. Nurse’s scientific journey.
I want to thank Jacky Hayles for critically reading this manuscript and Tim Humphreys for information on Wee1 cancer therapy. The middle part of this account is based on my essay Learning from the Uncontrollable, Cell, 165 (p1301–1306) (2016). This article is dedicated to all my lab colleagues that I have had the privilege to work with. This work was supported by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC01121), the UK Medical Research Council (FC01121), and the Wellcome Trust (FC01121). In addition this work was supported by Wellcome Trust Grant [grant number 093917], The Breast Cancer Research Foundation and The Rockefeller University.
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