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Molecular Medicine

, Volume 20, Issue 1, pp 17–28 | Cite as

Underexpressed CNDP2 Participates in Gastric Cancer Growth Inhibition through Activating the MAPK Signaling Pathway

  • Zhenwei Zhang
  • Lei Miao
  • Xiaoming Xin
  • Jianpeng Zhang
  • Shengsheng Yang
  • Mingyong Miao
  • Xiangping Kong
  • Binghua Jiao
Research Article

Abstract

Increasing evidence suggests that cytosolic non-specific dipeptidase 2 (CNDP2) appears to do more than just perform an enzymatic activity; it is functionally important in cancers as well. Here, we show that the expression of CNDP2 is commonly down-regulated in gastric cancer tissues. The ectopic expression of CNDP2 resulted in significant inhibition of cell proliferation, induction of cell apoptosis and cell cycle arrest, and suppressed gastric tumor growth in nude mice. We further revealed that the reintroduction of CNDP2 transcriptionally upregulated p38 and activated c-Jun NH2-terminal kinase (JNK), whereas the loss of CNDP2 increased the phosphorylation of extracellular signal-related kinase (ERK). These results suggest that CNDP2 acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway.

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Authors and Affiliations

  • Zhenwei Zhang
    • 1
    • 2
  • Lei Miao
    • 3
  • Xiaoming Xin
    • 3
    • 4
  • Jianpeng Zhang
    • 1
  • Shengsheng Yang
    • 1
  • Mingyong Miao
    • 1
  • Xiangping Kong
    • 2
  • Binghua Jiao
    • 1
  1. 1.Department of Biochemistry and Molecular BiologySecond Military Medical UniversityShanghaiChina
  2. 2.Key Laboratory of Liver Disease, Center of Infectious DiseasesGuangzhou 458 HospitalGuangzhouChina
  3. 3.Department of Pharmacology, School of Pharmacy and Institute of Biomedical SciencesFudan UniversityShanghaiChina
  4. 4.Department of PharmacologyTaishan Medical UniversityShandong ProvinceChina

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