Human “Orchestrator” CD11b+ B1 Cells Spontaneously Secrete Interleukin-10 and Regulate T-Cell Activity
Immune regulation produced by B cells has been attributed to production and secretion of interleukin (IL)-10, which is a characteristic of mouse B1 cells. In view of the widespread clinical use of B-cell depletion therapies in autoimmune and malignant diseases, it is important to monitor the function and fate of regulatory B cells. However, there is no consensus regarding the phenotypic identity of human IL-10+ B cells. Here we show that human CD11b+ B1 cells, one of two recently described subpopulations of B1 cells, spontaneously produce IL-10 and suppress T-cell activation. In view of the capacity of these B cells to either stimulate T-cell proliferation or suppress T-cell activation, CD11b+ B1 cells are considered to be capable of orchestrating elements of immune responsiveness and thus are termed “orchestrator B1 cells,” or “B1orc,” whereas CD11b− B1 cells that primarily secrete antibody are termed “secretor B1 cells,” or “B1sec.”
The authors gratefully acknowledge support from the National Institutes of Health (grant AI29690) and the Zucker Family Foundation.
DO Griffin and TL Rothstein designed the study. DO Griffin performed the experiments. DO Griffin and TL Rothstein analyzed the data and contributed to the final manuscript.
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