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Molecular Medicine

, Volume 17, Issue 11–12, pp 1133–1136 | Cite as

Transcription Factor Networks as Targets for Therapeutic Intervention of Cancer: The Breast Cancer Paradigm

  • Michalis V. Karamouzis
  • Athanasios G. Papavassiliou
Commentary

Abstract

It has long been shown that many of the presently used anticancer drugs exert their effects partly through modulating the activity of vital transcription factors. The intricacy of transcriptional regulation still represents the main obstacle for the design of transcription factor-directed agents. Systematic mapping of tumor-specific transcriptional networks and application of new molecular tools have reinforced research interest and efforts in this venue. The case of breast cancer is discussed as a representative example.

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Copyright information

© The Feinstein Institute for Medical Research 2011

Authors and Affiliations

  • Michalis V. Karamouzis
    • 1
  • Athanasios G. Papavassiliou
    • 1
  1. 1.Department of Biological Chemistry, Molecular Oncology UnitUniversity of Athens Medical SchoolAthensGreece

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