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Molecular Medicine

, Volume 17, Issue 11–12, pp 1383–1396 | Cite as

Selective IgA Deficiency in Autoimmune Diseases

  • Ning Wang
  • Nan Shen
  • Timothy J. Vyse
  • Vidya Anand
  • Iva Gunnarson
  • Gunnar Sturfelt
  • Solbritt Rantapää-Dahlqvist
  • Kerstin Elvin
  • Lennart Truedsson
  • Bengt A. Andersson
  • Charlotte Dahle
  • Eva Örtqvist
  • Peter K. Gregersen
  • Timothy W. Behrens
  • Lennart Hammarström
Invited Review Article

Abstract

Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves disease (GD), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), celiac disease (CD), myasthenia gravis (MG) and rheumatoid arthritis (RA) on the basis of both our own recent large-scale screening results and literature data. Genetic factors are important for the development of both IgAD and various autoimmune disorders, including GD, SLE, T1D, CD, MG and RA, and a strong association with the major histocompatibility complex (MHC) region has been reported. In addition, non-MHC genes, such as interferon-induced helicase 1 (IFIH1) and c-type lectin domain family 16, member A (CLEC16A), are also associated with the development of IgAD and some of the above diseases. This indicates a possible common genetic background. In this review, we present suggestive evidence for a shared genetic predisposition between these disorders.

Notes

Acknowledgments

This work was supported by the Swedish Research Council, the European Union-funded project EURO-PADnet (grant 201 549) and the KI funding for PhD students program for PhD students at the Karolinska Institutet (N Wang). We are indebted to Francesco Cucca at the University of Sassari, Italy, for providing samples from Italian patients with T1D and Magdalena Janzi and Ryan Ramanujam for their contributions in the early stages of this work.

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Copyright information

© The Feinstein Institute for Medical Research 2011

Authors and Affiliations

  • Ning Wang
    • 1
  • Nan Shen
    • 2
  • Timothy J. Vyse
    • 3
  • Vidya Anand
    • 3
  • Iva Gunnarson
    • 4
  • Gunnar Sturfelt
    • 5
  • Solbritt Rantapää-Dahlqvist
    • 6
  • Kerstin Elvin
    • 7
  • Lennart Truedsson
    • 8
  • Bengt A. Andersson
    • 9
  • Charlotte Dahle
    • 10
  • Eva Örtqvist
    • 11
  • Peter K. Gregersen
    • 12
  • Timothy W. Behrens
    • 13
  • Lennart Hammarström
    • 1
  1. 1.Division of Clinical Immunology, Department of Laboratory MedicineKarolinska Institutet at Karolinska University Hospital HuddingeStockholmSweden
  2. 2.Department of Rheumatology, Renji HospitalJiaoTong University School of MedicineShanghaiChina
  3. 3.Section of Molecular Genetics and RheumatologyHammersmith HospitalLondonUK
  4. 4.Rheumatology Unit, Department of MedicineKarolinska University Hospital SolnaStockholmSweden
  5. 5.Department of RheumatologyLund University HospitalLundSweden
  6. 6.Department of RheumatologyUniversity HospitalUmeåSweden
  7. 7.Unit of Clinical Immunology, Department of Clinical Immunology and Transfusion MedicineKarolinska University Hospital HuddingeStockholmSweden
  8. 8.Department of Laboratory Medicine, Section of Microbiology, Immunology and GlycobiologyLund UniversityLundSweden
  9. 9.Department of ImmunologySahlgrenska AcademyGothenburgSweden
  10. 10.Clinical Immunology Unit, Department of Clinical and Experimental MedicineLinköping UniversityLinköpingSweden
  11. 11.Department of Woman and Child Health, Astrid Lindgren Children’s HospitalKarolinska University Hospital SolnaStockholmSweden
  12. 12.Robert S. Boas Center for Genomics and Human GeneticsFeinstein Institute for Medical ResearchManhassetUSA
  13. 13.Division of Immunology, Tissue Growth & Repair, Biomarker Discovery and Human GeneticsGenentechSouth San FranciscoUSA

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