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Molecular Medicine

, Volume 17, Issue 5–6, pp 378–390 | Cite as

Histone Deacetylase (HDAC) Inhibition as a Novel Treatment for Diabetes Mellitus

  • Dan P Christensen
  • Mattias Dahllöf
  • Morten Lundh
  • Daniel N Rasmussen
  • Mette D Nielsen
  • Nils Billestrup
  • Lars G Grunnet
  • Thomas Mandrup-Poulsen
Review Article

Abstract

Both common forms of diabetes have an inflammatory pathogenesis in which immune and metabolic factors converge on interleukin-1β as a key mediator of insulin resistance and β-cell failure. In addition to improving insulin resistance and preventing β-cell inflammatory damage, there is evidence of genetic association between diabetes and histone deacetylases (HDACs); and HDAC inhibitors (HDACi) promote β-cell development, proliferation, differentiation and function and positively affect late diabetic microvascular complications. Here we review this evidence and propose that there is a strong rationale for preclinical studies and clinical trials with the aim of testing the utility of HDACi as a novel therapy for diabetes.

Notes

Acknowledgments

This review was written with financial support from the Novo Nordisk Foundation, the Juvenile Diabetes Research Foundation International grant 26-2008-893, the University of Copenhagen and the Novo Nordisk TRAP Program.

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Copyright information

© The Feinstein Institute for Medical Research 2011

Authors and Affiliations

  • Dan P Christensen
    • 1
  • Mattias Dahllöf
    • 1
  • Morten Lundh
    • 1
  • Daniel N Rasmussen
    • 1
  • Mette D Nielsen
    • 1
  • Nils Billestrup
    • 2
  • Lars G Grunnet
    • 1
  • Thomas Mandrup-Poulsen
    • 1
    • 3
    • 4
    • 5
  1. 1.Center for Medical Research Methodology, Department of Biomedical Sciences, The Panum InstituteUniversity of CopenhagenCopenhagen NDenmark
  2. 2.Cellular and Metabolic Research, Department of Biomedical SciencesUniversity of CopenhagenCopenhagenDenmark
  3. 3.Department for Diabetes InflammationHagedorn Research InstituteGentofteDenmark
  4. 4.Department of Medicine and SurgeryKarolinska InstituteStockholmSweden
  5. 5.Institute of Biomedical Sciences, the Panum InstituteUniversity of CopenhagenCopenhagenDenmark

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