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Molecular Medicine

, Volume 14, Issue 11–12, pp 741–751 | Cite as

Adipokines and Insulin Resistance

  • Katja Rabe
  • Michael Lehrke
  • Klaus G. Parhofer
  • Uli C. Broedl
Review Article

Abstract

Obesity is associated with an array of health problems in adult and pediatric populations. Understanding the pathogenesis of obesity and its metabolic sequelae has advanced rapidly over the past decades. Adipose tissue represents an active endocrine organ that, in addition to regulating fat mass and nutrient homeostasis, releases a large number of bioactive mediators (adipokines) that signal to organs of metabolic importance including brain, liver, skeletal muscle, and the immune system— thereby modulating hemostasis, blood pressure, lipid and glucose metabolism, inflammation, and atherosclerosis. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones adiponectin, chemerin, leptin, omentin, resistin, retinol binding protein 4, tumor necrosis factor-α and interleukin-6, vaspin, and visfatin on insulin resistance.

Notes

Acknowledgments

This work was supported by a grant from the Deutsche Forschungsgemeinschaft (BR 2151/4-1 to UCB).

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Copyright information

© Feinstein Institute for Medical Research 2008

Authors and Affiliations

  • Katja Rabe
    • 1
  • Michael Lehrke
    • 1
  • Klaus G. Parhofer
    • 1
  • Uli C. Broedl
    • 1
  1. 1.Department of Internal Medicine IIUniversity of MunichMunichGermany

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