Epileptic Disorders

, Volume 12, Issue 2, pp 146–150 | Cite as

Levetiracetam-induced seizure aggravation associated with continuous spikes and waves during slow sleep in children with refractory epilepsies

  • Roberto H. Caraballo
  • Ricardo Cersósimo
  • Cecilia De los Santos
Clinical Commentary


We present a patient with cryptogenic focal epilepsy and another with Dravet syndrome, who experienced seizure aggravation and negative myoclonus, associated with continuous spikes and waves during slow sleep, induced by levetiracetam. For both patients levetiracetam was discontinued, and there was significant improvement of this particular electroclinical picture.

Key words

aggravation continuous spikes and waves during slow sleep Dravet syndrome negative myoclonus levetiracetam 


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Copyright information

© John Libbey Eurotext and Springer 2010

Authors and Affiliations

  • Roberto H. Caraballo
    • 1
    • 2
  • Ricardo Cersósimo
    • 1
  • Cecilia De los Santos
    • 1
  1. 1.Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”Buenos AiresArgentina
  2. 2.Neurology DepartmentHospital de Pediatría “Prof. Dr. Juan P. Garrahan”Buenos AiresArgentina

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