Epileptic Disorders

, Volume 12, Issue 1, pp 84–87 | Cite as

Focal epileptic seizure induced by transient hypoglycaemia in insulin-treated diabetes

  • Leonardo Lapenta
  • Carlo Di Bonaventura
  • Jinane Fattouch
  • Francesca Bonini
  • Simona Petrucci
  • Silvia Gagliardi
  • Sara Casciato
  • Mario Manfredi
  • Massimiliano Prencipe
  • Anna Teresa Giallonardo
Clinical Commentary
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Abstract

Hypoglycaemia, common in diabetic patients treated with insulin, can induce various neurological disturbances. Of these, seizures are the most common acute symptom, mainly of the generalised tonic-clonic type, with focal events only exceptionally being reported and documented. Hypoglycaemia can modify cortical excitability by determining an imbalance between excitation and inhibition; some brain structures, such as the temporal lobe and hippocampus, appear to be particularly susceptible to this insult. We describe a case of a 61-year-old diabetic patient in whom insulin-induced transient hypoglycaemia triggered a focal seizure of temporal origin that was well documented by EEG during 24-hour ambulatory monitoring. This is, to our knowledge, one of the few, well-documented cases of this type of seizure.

Key words

hypoglycaemia epileptic seizure acute symptom diabetes 

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Copyright information

© John Libbey Eurotext and Springer 2010

Authors and Affiliations

  • Leonardo Lapenta
    • 1
    • 3
  • Carlo Di Bonaventura
    • 1
  • Jinane Fattouch
    • 1
  • Francesca Bonini
    • 1
  • Simona Petrucci
    • 1
  • Silvia Gagliardi
    • 1
  • Sara Casciato
    • 1
  • Mario Manfredi
    • 1
    • 2
  • Massimiliano Prencipe
    • 1
  • Anna Teresa Giallonardo
    • 1
  1. 1.Department of Neurological SciencesPoliclinico Umberto IRomeItaly
  2. 2.Neuromed Institute of Pozzilli IRCSS“Sapienza” University of RomeRomeItaly
  3. 3.Department of Neurological SciencesUniversity of RomeRomeItaly

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