Locally advanced head and neck squamous cell carcinoma and melanoma simultaneously treated with pembrolizumab: an unusual situation

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  1. 1.

    Lomas A, Leonardi-Bee J, Bath-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol 2012; 166: 1069–80.

    CAS  Article  Google Scholar 

  2. 2.

    Stevenson ML, Wang CQ, Abikhair M, et al. Expression of programmed cell death ligand in cutaneous squamous cell carcinoma and treatment of locally advanced disease with pembrolizumab. JAMA Dermatol 2017; 153: 299–303.

    Article  Google Scholar 

  3. 3.

    Cohen EEW, Soulières D, LeTourneau C, et al. Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study. Lancet 2019; 393: 156–67.

    CAS  Article  Google Scholar 

  4. 4.

    Eggermont AMM, Blank CU, Mandala M, et al. adjuvant pembrolizumab versus placebo in resected Stage III melanoma. N Engl J Med 2018; 378: 1789–801.

    CAS  Article  Google Scholar 

  5. 5.

    Lee CH, Yelensky R, Jooss K, Chan TA. Update on tumor neoantigens and their utility: why it is good to be different. Trends Immunol 2018; 39: 536–48.

    CAS  Article  Google Scholar 

  6. 6.

    Garcia-Diez I, Hernandez-Ruiz E, Andrades E, et al. PD-L1 Expression is increased in metastasizing squamous cell carcinomas and their metastases. Am J Dermatopathol 2018; 40: 647–54.

    Article  Google Scholar 

  7. 7.

    Veness MJ, Quinn DI, Ong CS, et al. Aggressive cutaneous malignancies following cardiothoracic transplantation: The Australian experience. Cancer 1999; 85: 1758–64.

    CAS  Article  Google Scholar 

  8. 8.

    Euvrard S, Kanitakis J, Claudy A. Skin cancers after organ transplantation. N Engl J Med 2003; 348: 1681–91.

    Article  Google Scholar 

  9. 9.

    Euvrard S, Kanitakis J, Decullier E, et al. Subsequent skin cancers in kidney and heart transplant recipients after the first squamous cell carcinoma. Transplantation 2006; 81: 1093–100.

    Article  Google Scholar 

  10. 10.

    Saavedra D, García B. Immunosenescence: effects of aging process on immune system. Rev Cubana Hematol Inmunol Hemoter 2014; 30: 332–45.

    Google Scholar 

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Correspondence to Verónica Mora-Fernández.

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Mora-Fernández, V., Boada, A., Manzano, JL. et al. Locally advanced head and neck squamous cell carcinoma and melanoma simultaneously treated with pembrolizumab: an unusual situation. Eur J Dermatol 30, 743–744 (2020). https://doi.org/10.1684/ejd.2020.3911

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