European Journal of Dermatology

, Volume 27, Issue 4, pp 363–368 | Cite as

Risk factors associated with relapse of eyelid basal cell carcinoma: results from a retrospective study of 142 patients

  • Giusy Fatigato
  • Silvano Capitani
  • Daniela Milani
  • Silvia Grassilli
  • Ayman Am Alameen
  • Marco Candiani
  • Carlo Riberti
  • Marco Galasso
  • Maurizio Previati
Clinical report
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Abstract

Background

Of skin cancers, 9% arise at the periocular level, constituting a significant threat due to the proximity to intracranial structures, such as the eyes, nerve endings and proximal tissues. Tumour recurrence can be frequent and represents a primary clinical challenge for the surgeon.

Objectives

To present a retrospective study on the treatment of eyelid tumours at a tertiary care centre in Italy over an eight-year period and, in particular, to underline the risk factors associated with tumour relapse.

Materials & methods

Among a cohort of 205 patients, a retrospective study was conducted on 142 basal cell carcinoma (BCC) patients with eyelid tumours treated with surgical excision. Relapse-free survival was assessed using univariate Kaplan-Meier and multivariate Cox regression analysis.

Results

Over an eight-year study period, we detected 23 cases of BCC recurrence, with tumour localization associating with tumour relapse, representing an independent risk factor. The extent of the area of excision was significantly associated with relapse, but not margin positivity whichwas associated with reduced relapse-free survival.

Conclusion

To minimize relapse of basal cell carcinoma during patient management, relevant factors to consider before and after tumour excision include tumour localization, margin invasion, and extension of the excision, but not the surgical technique used.

Key words

basal cell carcinoma eyelid reconstructive surgery skin cancer 

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Copyright information

© John Libbey Eurotext 2017

Authors and Affiliations

  • Giusy Fatigato
    • 1
    • 2
  • Silvano Capitani
    • 3
    • 4
  • Daniela Milani
    • 4
  • Silvia Grassilli
    • 4
  • Ayman Am Alameen
    • 4
  • Marco Candiani
    • 1
  • Carlo Riberti
    • 1
  • Marco Galasso
    • 3
    • 4
  • Maurizio Previati
    • 3
    • 4
  1. 1.Department of Morphology, Surgery and Experimental Medicine, Surgery and Translational Medicine SectionUniversity of FerraraFerraraItaly
  2. 2.Department of Emergency and Organ Transplantation, Plastic and Reconstructive Surgery UnitUniversity of BariBariItaly
  3. 3.LTTA CentreUniversity of FerraraFerraraItaly
  4. 4.Department of Morphology, Surgery and Experimental Medicine, Anatomy and Histology SectionUniversity of FerraraFerraraItaly

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