European Journal of Dermatology

, Volume 25, Issue 5, pp 410–417 | Cite as

Long-term (1 year) efficacy of etanercept in moderate-to-severe psoriasis. Results of a multicentric observational study in Spain

  • Lluís Puig
  • Francisco Camacho
  • Vicente García-Patos
  • Maria Luisa Fernández-Díaz
  • Amparo Marquina
  • Carmen García-Calvo
Therapy
  • 36 Downloads

Abstract

Background

Information on the long-term efficacy of etanercept (ETN) treatment of moderate-to-severe psoriasis according to the Summary of Product Characteristics (SmPC) is scarce.

Objectives

We report the efficacy results of an observational clinical trial including 202 patients treated for 12 months with ETN according to SmPC.

Methods

Concomitant topical treatment was permitted throughout the study period. Efficacy assessment was done by intention-to-treat analysis with last observation carried forward.

Results

Mean%Body Surface Area (BSA) and Psoriasis Area and Severity Index (PASI) decreased from 39.0% and 22.2% at baseline to 7.9% and 4.4%, respectively, at 12 months. Throughout the study duration, PASI 50, PASI 75 and PASI 90 response rates ranged from 72.8% to 95.7%, 55.6% to 84.3%, and 36.1% to 62.2%, respectively. Body mass index and body weight had minor effects on treatment efficacy.

Conclusion

ETN treatment according to the SmPC provided sustained improvement of psoriasis throughout one year.

Key words

efficacy etanercept psoriasis 

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Copyright information

© John Libbey Eurotext 2015

Authors and Affiliations

  • Lluís Puig
    • 1
  • Francisco Camacho
    • 2
  • Vicente García-Patos
    • 3
  • Maria Luisa Fernández-Díaz
    • 4
  • Amparo Marquina
    • 5
  • Carmen García-Calvo
    • 6
  1. 1.Dermatology DepartmentHospital de la Santa Creu i Sant PauBarcelona, CatalunyaSpain
  2. 2.Departamento de DermatologíaHospital Virgen de la MacarenaSevillaSpain
  3. 3.Hospital Universitario Vall d’HebronBarcelonaSpain
  4. 4.Servicio de DermatologíaHospital Universitario Lucus AugustiLugoSpain
  5. 5.Servicio de DermatologíaHospital Universitario Doctor PesetValenciaSpain
  6. 6.Departamento Médico PfizerMadridSpain

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