Vitamin D insufficiency is associated with higher carotid intima-media thickness in psoriatic patients
- 37 Downloads
Psoriasis has been associated with vitamin D insufficiency and cardiovascular risk factors. Reports show that serum 25-hydroxyvitamin D (25-OHD) levels are inversely associated with chronic inflammatory systemic diseases, cardiovascular risk factors and cardiovascular outcomes.
To analyze the association between 25-hydroxyvitamin D serum levels and subclinical carotid atherosclerosis (maximal intima-media thickness (MIMT)) in psoriasis patients and controls. MIMT was compared and associated factors were analyzed.
Patients and Method
This was a case-control study with 44 psoriatic patients without arthritis from a Dermatology outpatient clinic in Granada (Spain) and 44 controls. Confounding factors related to 25-OHD serum levels and cardiovascular risk factors were also analyzed.
25-OHD levels were significantly lower in the psoriatic than in the control group (29.20 vs. 38.00 ng/mL p<0.0001) and a significant negative correlation was found between serum 25-OHD levels and the MIMT (rs = −0.678, p<0.0001) in psoriatic patients. No correlation was found in healthy controls. This association remained after adjusting for confounders. Serum 25-OHD levels were significantly lower (p = 0.003) in psoriatic patients with carotid atheromatous plaque (22.38 ± 10.23 ng/mL) than in those without (31.74 ± 8.62 ng/mL). Patients with a longer history of psoriasis presented significantly higher MIMT than controls (638.70 ± 76.21 vs 594.67 ± 80.20 μm; p = 0.026 for ≥6 yrs with psoriasis).
In psoriasis patients, lower serum 25-OHD levels were associated with higher MIMT after adjusting for selected confounding factors. The MIMT risk increases with a longer history of psoriasis, regardless of the patient’s age.
Keywordsvitamin D 25-hydroxyvitamin D carotid artery atherosclerosis cardiovascular risk factors psoriasis
Unable to display preview. Download preview PDF.
- 2.O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group.NEngl J Med 1999; 340: 14–22.Google Scholar
- 17.Emaus A, Degerstrøm J, Wilsgaard T, et al. Does a variation in self-reported physical activity reflect variation in objectively measured physical activity, resting heart rate, and physical fitness? Results from the Tromso study. Scand J Public Health. 2010; 38(Suppl. 5): 105–118.PubMedCrossRefGoogle Scholar
- 18.Stein JH, Korcarz CE, Hurst RT, et al. American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr 2008; 21: 93–111.PubMedCrossRefGoogle Scholar
- 36.Lau SL, Gunton JE, Athayde NP, Byth K, Cheung NW. Serum 25-hydroxyvitamin D and glycated haemoglobin levels in women with gestational diabetes mellitus. Med J Aus 2011; 194: 334–337.Google Scholar
- 51.Di Minno MN, Iervolino S, Peluso R, Scarpa R, Di Minno G, CaRRDs study group G. Carotid intima-media thickness in psoriatic arthritis: differences between tumor necrosis factor-α blockers and traditional disease-modifying antirheumatic drugs. Arterioscler Thromb Vasc Biol 2011; 31: 705–712.PubMedCrossRefGoogle Scholar