European Journal of Dermatology

, Volume 24, Issue 2, pp 147–153 | Cite as

Small-fibre neuropathies and skin: news and perspectives for dermatologists

  • Laurent Misery
  • Céline Bodere
  • Steeve Genestet
  • Fabien Zagnoli
  • Pascale Marcorelles
Review Article


Small-fibre neuropathies (SFNs) can be defined as diseases of small nerve fibres. Because their symptoms are mainly located in the skin in the initial stages, dermatologists may frequently be confronted with these diseases. Moreover, skin biopsies and the subsequent measurement of intraepidermal nerve fibre density have become a widely accepted technique to investigate the structural integrity of small nerve fibres. The pathogenesis of injury to small nerve fibres is poorly understood. It probably depends on the cause. SCN9A-gene variants have been reported. Diabetes mellitus is one of the main causes of SFNs. Some causes of SFNs are very well-known to dermatologists: Gougerot-Sjögren syndrome, lupus, sarcoidosis and Fabry disease. We also discuss erythermalgia, prurigo nodularis, nummular eczema, burning mouth syndrome and sensitive skin as SFNs.

Key words

small-fibre neuropathy PGP9.5 nerve Gougerot-Sjögren syndrome sarcoidosis Fabry disease erythermalgia pruritus burning mouth syndrome sensitive skin 


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Copyright information

© John Libbey Eurotext 2014

Authors and Affiliations

  • Laurent Misery
    • 1
    • 2
    • 3
  • Céline Bodere
    • 1
    • 4
  • Steeve Genestet
    • 2
    • 5
  • Fabien Zagnoli
    • 1
    • 2
    • 6
  • Pascale Marcorelles
    • 1
    • 2
    • 7
  1. 1.Laboratory of Neurosciences of BrestUniversity of Western BrittanyBrestFrance
  2. 2.Breton Competence Centre of RareNeuro-Muscular Diseases and Neuropathies with Cutaneous-Mucosal SymptomsBrestFrance
  3. 3.Department of dermatologyArmed Forces Instruction Hospital Clermont-TonnerreBrestFrance
  4. 4.Department of odontologyArmed Forces Instruction Hospital Clermont-TonnerreBrestFrance
  5. 5.Department of clinical neurophysiologyArmed Forces Instruction Hospital Clermont-TonnerreBrestFrance
  6. 6.Department of neurologyArmed Forces Instruction Hospital Clermont-TonnerreBrestFrance
  7. 7.Department of pathologyUniversity Hospital of BrestBrestFrance

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