European Journal of Dermatology

, Volume 28, Issue 3, pp 343–350 | Cite as

Comparable efficacy of adapalene 0.3% gel and tretinoin 0.05% cream as treatment for cutaneous photoaging

  • Ediléia BagatinEmail author
  • Heitor de Sá Gonçalves
  • Maurício Sato
  • Luiz Maurício Costa Almeida
  • Helio Amante Miot



Adapalene has been previously evaluated as a treatment for actinic keratosis (AK) and solar lentigines and shown to improve signs of photoaging.


To evaluate whether adapalene 0.3% gel is non-inferior to tretinoin 0.05% cream as treatment for photoaged skin.

Materials & Methods

An investigator-blinded, parallel-group comparison study was conducted in Brazil. Subjects were randomised in a 1:1 ratio to receive, once daily, adapalene 0.3% gel or tretinoin 0.05% cream. Subjects were evaluated at Weeks 1, 4, 8, 12, 16, 20 and 24, based on clinical signs of cutaneous photoaging, histopathological and digital morphometric findings, as well as safety and tolerability.


A comparison of clinical efficacy showed that both treatments did not differ significantly regarding clinical evaluation of the following criteria: global cutaneous photoaging, periorbital wrinkles, ephelides/melanosis, forehead wrinkles, and AK.


Adapalene 0.3% gel showed non-inferior efficacy to tretinoin 0.05% cream as treatment for photoaged skin, with a similar safety profile. Adapalene 0.3% gel may therefore be considered a safe and effective option for the treatment of mild or moderate photoaging.

Key words

adapalene melanosis photoaging retinoid tretinoin wrinkles 


  1. 1.
    Fisher GJ, Kang S, Varani J, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol 2002; 138: 1462–70.CrossRefPubMedGoogle Scholar
  2. 2.
    Rabe JH, Mamelak AJ, McElgunn PJ, Morison WL, Sauder DN. Photoaging:mechanisms and repair. J Am Acad Dermatol 2006; 55: 1–19.CrossRefPubMedGoogle Scholar
  3. 3.
    Kang S, Fisher GJ, Voorhees JJ. Photoaging:pathogenesis, prevention, and treatment. Clin Geriatr Med 2001; 17: 643–59.CrossRefPubMedGoogle Scholar
  4. 4.
    Poon F, Kang S, Chien AL. Mechanisms and treatments of photoaging. Photodermatol Photoimmunol Photomed 2015; 31: 65–74.CrossRefPubMedGoogle Scholar
  5. 5.
    Ascenso A, Ribeiro H, Marques HC, Oliveira H, Santos C, Simoes S. Is tretinoin still a key agent for photoaging management? Mini Rev Med Chem 2014; 4: 629–41.CrossRefGoogle Scholar
  6. 6.
    Kircik LH. Histologic improvement in photodamage after 12 months of treatment with tretinoin emollient cream (0.02%). J Drugs Dermatol 2012; 11: 1036–40.PubMedGoogle Scholar
  7. 7.
    Bagatin E, Guadanhim LR, Enokihara MM, et al. Low–dose oral isotretinoin versus topical retinoic acid for photoaging:a randomized, comparative study. Int J Dermatol 2014; 53: 114–22.CrossRefPubMedGoogle Scholar
  8. 8.
    Phillips TJ, Gottlieb AB, Leyden JJ, et al. Efficacy of 0.1% tazarotene cream for the treatment of photodamage:a 12–month multicenter, randomized trial. Arch Dermatol 2002; 138: 1486–93.PubMedGoogle Scholar
  9. 9.
    Baldwin HE, Nighland M, Kendall C, Mays DA, Grossman R, Newburger J. 40 years of topical tretinoin use in review. J Drugs Dermatol 2013; 12: 638–42.PubMedGoogle Scholar
  10. 10.
    Kang S, Leyden JJ, Lowe NJ, et al. Tazarotene cream for the treatment of facial photodamage:a multicenter, investigatormasked, randomized, vehicle–controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks. Arch Dermatol 2001; 137: 1597–604.CrossRefPubMedGoogle Scholar
  11. 11.
    Thiboutot D, Pariser DM, Egan N, et al. Adapalene gel 0.3% for the treatment of acne vulgaris:a multicenter, randomized, double–blind, controlled, phase III trial. J Am Acad Dermatol 2006; 54: 242–50.CrossRefPubMedGoogle Scholar
  12. 12.
    Pariser DM, Thiboutot DM, Clark SD, et al. The efficacy and safety of adapalene gel 0.3% in the treatment of acne vulgaris:a randomized, multicenter, investigator–blinded, controlled comparison study versus adapalene gel 0.1% and vehicle. Cutis 2005; 76: 145–51.PubMedGoogle Scholar
  13. 13.
    Kang S, Goldfarb MT, Weiss JS, et al. Assessment of adapalene gel for the treatment of actinic keratoses and lentigines:a randomized trial. J Am Acad Dermatol 2003; 49: 83–90.CrossRefPubMedGoogle Scholar
  14. 14.
    Herane MI, Orlandi C, Zegpi E, Valdes P, Ancic X. Clinical efficacy of adapalene (differin(®)) 0.3% gel in Chilean women with cutaneous photoaging. J Dermatolog Treat 2012; 23: 57–64.CrossRefPubMedGoogle Scholar
  15. 15.
    Griffiths CE,Wang TS, Hamilton TA, Voorhees JJ, Ellis CN. A photonumeric scale for the assessment of cutaneous photodamage. Arch Dermatol 1992; 128: 347–51.CrossRefPubMedGoogle Scholar
  16. 16.
    Ishibashi H, Suzuki T, Suzuki S, et al. Sex steroid hormone receptors in human thymoma. J Clin Endocrinol Metab 2003; 88: 2309–17.CrossRefPubMedGoogle Scholar
  17. 17.
    Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ:25 years of image analysis. Nat Methods 2012; 9: 671–5.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Miot HA, Brianezi G, Tamega Ade A, Miot LD. Techniques of digital image analysis for histological quantification of melanin. An Bras Dermatol 2012; 87: 608–11.CrossRefPubMedGoogle Scholar
  19. 19.
    Brianezi G, Grandi F, Bagatin E, Enokihara MM, Miot HA. Dermal type I collagen assessment by digital image analysis. An Bras Dermatol 2015; 90: 723–7.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Antoniou C, Kosmadaki MG, Stratigos AJ, Katsambas AD. Sunscreens–what’s important to know. J Eur Acad Dermatol Venereol 2008; 22: 1110–8.CrossRefPubMedGoogle Scholar
  21. 21.
    Kligman AM, Grove GL, Hirose R, Leyden JJ. Topical tretinoin for photoaged skin. J Am Acad Dermatol 1986; 15: 836–59.CrossRefPubMedGoogle Scholar
  22. 22.
    Sorg O, Antille C, Kaya G, Saurat JH. Retinoids in cosmeceuticals. Dermatol Ther 2006; 19: 289–96.CrossRefPubMedGoogle Scholar
  23. 23.
    Stratigos AJ, Katsambas AD. The role of topical retinoids in the treatment of photoaging. Drugs 2005; 65: 1061–72.CrossRefPubMedGoogle Scholar
  24. 24.
    Shroot B, Michel S. Pharmacology and chemistry of adapalene. J Am Acad Dermatol 1997;36:S96–103.CrossRefPubMedGoogle Scholar
  25. 25.
    Lowe N, Gifford M, Tanghetti E, et al. Tazarotene 0.1% cream versus tretinoin 0.05% emollient cream in the treatment of photodamaged facial skin:a multicenter, double–blind, randomized, parallel–group study. J Cosmet Laser Ther 2004; 6: 79–85.CrossRefPubMedGoogle Scholar
  26. 26.
    Fisher GJ, Datta SC, Talwar HS, et al. Molecular basis of suninduced premature skin ageing and retinoid antagonism. Nature 1996; 379: 335–9.CrossRefPubMedGoogle Scholar
  27. 27.
    Czernielewski J, Michel S, Bouclier M, Baker M, Hensby JC. Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne. J Eur Acad Dermatol Venereol 2001; 15: 5–12.CrossRefPubMedGoogle Scholar

Copyright information

© John Libbey Eurotext 2018

Authors and Affiliations

  • Ediléia Bagatin
    • 1
    • 2
    Email author
  • Heitor de Sá Gonçalves
    • 3
  • Maurício Sato
    • 4
  • Luiz Maurício Costa Almeida
    • 5
    • 6
  • Helio Amante Miot
    • 7
  1. 1.Department of DermatologyFederal University of São PauloSão PauloBrazil
  2. 2.Translational Medicine Post-Graduation ProgramFederal University of São PauloSão PauloBrazil
  3. 3.Dona Libânia Dermatology center, Department of HealthCearáBrazil
  4. 4.Federal University of ParanáParanáBrazil
  5. 5.Department of DermatologyMedical Sciences CollegeBelo HorizonteBrazil
  6. 6.Preceptor of the medical residency of the Santa CasaSão PauloBrazil
  7. 7.Department of DermatologyFMB-UnespSão PauloBrazil

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