European Journal of Dermatology

, Volume 28, Issue 3, pp 406–407 | Cite as

Clinical course of the first Japanese family with Marie Unna hereditary hypotrichosis: a follow-up report

  • Yurika Masuda
  • Taisuke ItoEmail author
  • Yutaka Shimomura
  • Masaaki Ogai
  • Jun-Ichi Sakabe
  • Yoshiki Tokura


  1. 1.
    Ito T, Shimomura Y, Ogai M, Sakabe J, Tokura Y. Identification of a novel heterozygous mutation in the first Japanese case of Marie Unna hereditary hypotrichosis. J Dermatol 2013; 40: 278–80.CrossRefPubMedGoogle Scholar
  2. 2.
    Yoshida K, Hayashi R, Shimomura Y, Niizeki H. Novel heterozygous mutation, c.74C>G (p.Pro25Arg), in the U2HR gene underlies Marie Unna hereditary hypotrichosis in a Japanese family. J Dermatol 2017; 44:e184–5.CrossRefGoogle Scholar
  3. 3.
    Wen Y, Liu Y, Xu Y, et al. Loss–of–function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat Genet 2009; 41: 228–33.CrossRefPubMedGoogle Scholar
  4. 4.
    Kim JK, Kim E, Baek IC, et al. Overexpression of Hr links excessive induction of Wnt signaling to Marie Unna hereditary hypotrichosis. Hum Mol Genet 2010; 19: 445–53.CrossRefPubMedGoogle Scholar
  5. 5.
    Unna M. Über hypotrichosis congenita hereditaria. Dermatol Wochenschr 1925; 8: 1167–78.Google Scholar
  6. 6.
    Yun SK, Cho YG, Song KH, et al. Identification of a novel U2HR mutation in a Korean woman with Marie Unna hereditary hypotrichosis. Int J Dermatol 2014; 53: 1358–61.CrossRefPubMedGoogle Scholar
  7. 7.
    Argenziano G, Sammarco E, Rossi A, Delfino M, Calvieri S. Marie Unna hereditary hypotrichosis. Eur J Dermatol 1999; 9: 278–80.PubMedGoogle Scholar
  8. 8.
    Srinivas SM, Hiremagalore R. Marie–Unna hereditary hypotrichosis. Int J Trichology 2014; 6: 182–4.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Sreekumar GP, Roberts JL, Wong CQ, Stenn KS, Parimoo S. Marie Unna hereditary hypotrichosis gene maps to human chromosome 8p21 near hairless. J Invest Dermatol 2000; 114: 595–7.CrossRefPubMedGoogle Scholar
  10. 10.
    Düzenli S, Redler S, Müller M, et al. Identification of a U2HR gene mutation in Turkish families with Marie Unna hereditary hypotrichosis. Clin Exp Dermatol 2009; 34:e953–6.CrossRefGoogle Scholar

Copyright information

© John Libbey Eurotext 2018

Authors and Affiliations

  • Yurika Masuda
    • 1
  • Taisuke Ito
    • 1
    Email author
  • Yutaka Shimomura
    • 2
  • Masaaki Ogai
    • 3
  • Jun-Ichi Sakabe
    • 4
  • Yoshiki Tokura
    • 1
  1. 1.Department of DermatologyHamamatsu University School of MedicineHamamatsuJapan
  2. 2.Department of DermatologyYamaguchi University Faculty of Medicine and Health SciencesYamaguchiJapan
  3. 3.Department of DermatologySeirei Hamamatsu General HospitalShizuokaJapan
  4. 4.Institute of Medical BiologyAgency for Science, Technology and Research (A*STAR)Singapore CitySingapore

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