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European Journal of Dermatology

, Volume 27, Issue 6, pp 620–626 | Cite as

Nail apparatus melanoma in a Japanese population: a comparative study of surgical procedures and prognoses in a large series of 151 cases

  • Dai OgataEmail author
  • Hisashi Uhara
  • Arata Tsutsumida
  • Naoya Yamazaki
  • Kosuke Mochida
  • Masahiro Amano
  • Shusuke Yoshikawa
  • Yoshio Kiyohara
  • Tetsuya Tsuchida
Clinical report

Abstract

Background

Nail apparatus melanoma (NAM) is a rare subtype of malignant melanoma with a prevalence that varies among populations. Conservative surgical approaches for thin to intermediate NAMs have recently been reported, however, their adoption is controversial, and resulting long-term prognoses are unknown.

Objectives

The purpose of this study was to determine the prognosis of NAM in a sample Asian population, and to investigate whether there is a difference in the local control and overall survival (OS) rates according to the extent of resection of the primary tumour.

Materials & methods

We performed a retrospective study of NAM patients treated at five medical institutions in Japan between 2000 and 2013. Outcomes according to surgery (amputation vs. resection) and tumour thickness were compared.

Results

We identified 151 cases of NAM in 83 men and 68 women; the thumb (n = 50; 33.1%) and hallux (n = 55; 36.4%) were the most common sites. No local recurrence was detected following any of the surgical procedures; Kaplan-Meier survival analysis revealed that the surgical procedure type was not significantly associated with disease-free survival (p = 0.786) or OS (p = 0.997). Five-year OS rates according to tumour thickness were 100% for in situ, 94.4% for ≤1-mm, 91.7% for 1.01-2.0-mm, 72.7% for 2.01-4.0-mm, and 47.6% for ≥4.01-mm tumours.

Conclusion

Surgical procedure type does not influence survival as long as total primary tumour resection is accomplished. The prognosis of NAMis comparable to that of other types of melanoma.

Key words

Nail apparatus melanoma overall survival surgical procedure subungual melanoma tumour thickness 

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Supplementary material

40699_2018_3133_MOESM1_ESM.pdf (44 kb)
Nail apparatus melanoma in a Japanese population: a comparative study of surgical procedures and prognoses in a large series of 151 cases

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Copyright information

© JLE/Springer 2018

Authors and Affiliations

  • Dai Ogata
    • 1
    • 2
    Email author
  • Hisashi Uhara
    • 3
  • Arata Tsutsumida
    • 4
  • Naoya Yamazaki
    • 4
  • Kosuke Mochida
    • 5
  • Masahiro Amano
    • 5
  • Shusuke Yoshikawa
    • 2
  • Yoshio Kiyohara
    • 2
  • Tetsuya Tsuchida
    • 1
  1. 1.Department of DermatologySaitama Medical UniversitySaitamaJapan
  2. 2.Division of DermatologyShizuoka Cancer Center HospitalShizuokaJapan
  3. 3.Department of DermatologyShinsyu UniversityNaganoJapan
  4. 4.Department of Dermatologic OncologyNational Cancer Center HospitalTokyoJapan
  5. 5.Department of DermatologyMiyazaki UniversityMiyazakiJapan

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