Abstract
Objective
The aim of this study was to explore the association of dopamine receptor D2 (DRD2) polymorphism and alleviation of obesity in children and adolescents after 8-year follow-up.
Methods
This retrospective cohort study included obese children and adolescents with a follow-up period of 8 years. Baseline clinical characteristics and DRD2 polymorphisms (including rs1076562, rs2075654, and rs4586205) were extracted from medical records. A follow-up visit was performed in May 2017 to collect related data including height, weight, diet compliance, and exercise compliance.
Results
One hundred and nine obese children and adolescents were included in the current study. Among three DRD2 single nucleotide polymorphisms, only rs2075654 had a statistically significant association with alleviation of obesity, as the alleviation rate for minor allele carriers (68.6% for TC+TT) was higher compared to the major allele homozygote (43.3% for CC). After adjusting for all related factors, the hazard ratio of rs2075654 minor allele carriers for the alleviation of obesity was 3.34 (95% confidence interval (CI): 1.30‒8.58).
Conclusions
The rs2075654 polymorphism of DRD2 is related to long-term obesity alleviation in obese Chinese children and adolescents.
中文概要
目的
在经过8 年随访的中国肥胖儿童青少年中,评价多巴胺受体D2(DRD2)基因多态性和肥胖缓解的相关性。
创新点
探索肥胖儿童青少年的基因多态性与长期体重变化的相关性,期望能够指导肥胖儿童青少年的临床诊疗。
方法
该研究纳入了我院随访8 年的108名肥胖儿童及青少年。基线的临床资料和 DRD2 基因多态性(包括rs1076562、rs2075654 和rs4586205)相关数据从原始病历及检验结果中提取。于2017 年5 月份 进行电话随访,采集相关数据,包括身高、体重、饮食和运动干预依从性。
结论
DRD2 基因rs2075654 位点多态性与肥胖儿童青少年的长期体重变化有相关性。
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References
1000 Genomes Project Consortium, Auton A, Brooks LD, et al., 2015. A global reference for human genetic variation. Nature, 526(7571):68-74. https://doi.org/10.1038/nature15393
Bray GA, Heisel WE, Afshin A, et al., 2018. The science of obesity management: an endocrine society scientific statement. Endocr Rev, 39(2):79–132. https://doi.org/10.1210/er.2017-00253
Carpenter CL, Wong AM, Li ZP, et al., 2013. Association of dopamine D2 receptor and leptin receptor genes with clinically severe obesity. Obesity (Silver Spring), 21(9): E467–E473. https://doi.org/10.1002/oby.20202
Collaboration NRF, 2017. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet, 390(10113):2627–2642. https://doi.org/10.1016/S0140-6736(17)32129-3
de Onis M, Onyango AW, Borghi E, et al., 2007. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ, 85(9):660–667. https://doi.org/10.2471/BLT.07.043497
Garcia-Tornadú I, Perez-Millan MI, Recouvreux V, et al., 2010. New insights into the endocrine and metabolic roles of dopamine D2 receptors gained from the Drd2–/–mouse. Neuroendocrinology, 92(4):207–214. https://doi.org/10.1159/000321395
Gosso MF, de Geus EJ, Polderman TJ, et al., 2008. Catechol O-methyl transferase and dopamine D2 receptor gene polymorphisms: evidence of positive heterosis and genegene interaction on working memory functioning. Eur J Hum Genet, 16(9):1075–1082. https://doi.org/10.1038/ejhg.2008.57
Hardman CA, Rogers PJ, Timpson NJ, et al., 2014. Lack of association between DRD2 and OPRM1 genotypes and adiposity. Int J Obes, 38(5):730–736. https://doi.org/10.1038/ijo.2013.144
Imed H, Jihene MM, Hamida BH, et al., 2009. Tracking of overweight among urban school children: a 4 years cohort study in Sousse Tunisia. J Public Health Epidemiol, 1(1): 31–36.
Julia M, van Weissenbruch MM, Prawirohartono EP, et al., 2008. Tracking for underweight, overweight and obesity from childhood to adolescence: a 5-year follow-up study in urban Indonesian children. Horm Res, 69(5):301–306. https://doi.org/10.1159/000114862
Kvaløy K, Holmen J, Hveem K, et al., 2015. Genetic effects on longitudinal changes from healthy to adverse weight and metabolic status—the HUNT study. PLoS ONE, 10(10): e0139632. https://doi.org/10.1371/journal.pone.0139632
Nakano T, Sei M, Ewis AA, et al., 2010. Tracking overweight and obesity in Japanese children; a six years longitudinal study. J Med Invest, 57(1-2):114–123. https://doi.org/10.2152/jmi.57.114
Ng M, Fleming T, Robinson M, et al., 2014. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 384(9945):766–781. https://doi.org/10.1016/s0140-6736(14)60460-8
Obregón AM, Valladares M, Goldfield G, 2017. Association of the dopamine D2 receptor rs1800497 polymorphism and eating behavior in Chilean children. Nutrition, 35: 139–145. https://doi.org/10.1016/j.nut.2016.11.005
Roth CL, Hinney A, Schur EA, et al., 2013. Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention. BMC Pediatr, 13:197. https://doi.org/10.1186/1471-2431-13-197
Sagar R, Gupta T, 2017. Psychological aspects of obesity in children and adolescents. Indian J Pediatr, 85(7):554–559. https://doi.org/10.1007/s12098-017-2539-2
Skinner AC, Perrin EM, Moss LA, et al., 2015. Cardiometabolic risks and severity of obesity in children and young adults. N Engl J Med, 373(14):1307–1317. https://doi.org/10.1056/NEJMoa1502821
Su LN, Wang YB, Wnag CG, et al., 2017. Network analysis identifies common genes associated with obesity in six obesity-related diseases. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 18(8):727–732. https://doi.org/10.1631/jzus.B1600454
Trivedi S, Burton A, Oden J, 2014. Management of pediatric obesity: a lifestyle modification approach. Indian J Pediatr, 81(2):152–157. https://doi.org/10.1007/s12098-013-1138-0
US Preventive Services Task Force, Grossman DC, Bibbins-Domingo K, et al., 2017. Screening for obesity in children and adolescents: US preventive services task force recommendation statement. JAMA, 317(23):2417-2426. https://doi.org/10.1001/jama.2017.6803
van de Giessen E, Celik F, Schweitzer DH, et al., 2014. Dopamine D2/3 receptor availability and amphetamineinduced dopamine release in obesity. J Psychopharmacol, 28(9):866–873. https://doi.org/10.1177/0269881114531664
Vizcaíno FM, Aguilar FS, Artalejo FR, et al., 2002. Obesity prevalence and tracking of body mass index after a 6 years follow up study in children and adolescents: the Cuenca Study, Spain. Med Clín, 119(9):327–330. https://doi.org/10.1016/s0025-7753(02)73406-4
Wang SS, Lay S, Yu HN, et al., 2016. Dietary Guidelines for Chinese Residents (2016): comments and comparisons. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 17(9):649–656. https://doi.org/10.1631/jzus.B1600341
Ward ZJ, Long MW, Resch SC, et al., 2017. Simulation of growth trajectories of childhood obesity into adulthood. N Engl J Med, 377(22):2145–2153. https://doi.org/10.1056/NEJMoa1703860
Yeh J, Trang A, Henning SM, et al., 2016. Food cravings, food addiction, and a dopamine-resistant (DRD2 A1) receptor polymorphism in Asian American college students. Asia Pac J Clin Nutr, 25(2):424–429. https://doi.org/10.6133/apjcn.102015.05
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Project supported by the National Natural Science Foundation of China (No. 11571309), the National Key Research and Development Programme of China (No. 2016YFC1305301), and the Jin Lei Pediatric Endocrinology Growth Research Fund for Young Physicians (No. PEGRF201405001), China
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Zhu, Jf., Chen, Lh., Yuan, K. et al. Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents. J. Zhejiang Univ. Sci. B 19, 807–814 (2018). https://doi.org/10.1631/jzus.B1800155
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DOI: https://doi.org/10.1631/jzus.B1800155