Abstract
Asthma is a chronic disease of airway inflammation due to excessive T helper cell type 2 (Th2) response. Present treatment based on inhalation of synthetic glucocorticoids can only control Th2-driven chronic eosinophilic inflammation, but cannot change the immune tolerance of the body to external allergens. Regulatory T cells (Tregs) are the main negative regulatory cells of the immune response. Tregs play a great role in regulating allergic, autoimmune, graft-versus-host responses, and other immune responses. In this review, we will discuss the classification and biological characteristics, the established immunomodulatory mechanisms, and the characteristics of induced differentiation of Tregs. We will also discuss the progress of Tregs in the field of asthma. We believe that further studies on the regulatory mechanisms of Tregs will provide better treatments and control strategies for asthma.
摘要
哮喘是一种由于II 型T 辅助细胞(Th2)反应过 度而引起的慢性气道炎症疾病。目前以吸入糖皮 质激素为基础的治疗仅能控制Th2 驱动的慢性嗜 酸性炎症,但是不能改变机体对外界过敏原的免 疫耐受状态。调节性T 细胞(Tregs)是免疫应答 的主要负调节细胞,Tregs 在调节变态反应、自 身免疫反应、移植物抗宿主反应和其他免疫反应 中发挥着重要作用。在本文中,我们综述了Tregs 的分类和生物学特性、免疫调节机制及诱导分化 特性。我们也探讨了Tregs 在哮喘领域的研究进 展。我们相信,进一步对Tregs 调控免疫反应机 制的研究会为哮喘防控提供更好的治疗方案和 策略
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Zhao, St., Wang, Cz. Regulatory T cells and asthma. J. Zhejiang Univ. Sci. B 19, 663–673 (2018). https://doi.org/10.1631/jzus.B1700346
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DOI: https://doi.org/10.1631/jzus.B1700346