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Advances in predicting the prognosis of hepatocellular carcinoma recipients after liver transplantation

肝癌肝移植术后受体预后相关因素的研究进展

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Abstract

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors worldwide. Liver transplantation (LT) is known as a curative and therapeutic modality. However, the survival rates of recipients after LT are still not good enough because of tumor recurrence. To improve the survival rates of recipients after LT, identifying predictive factors for prognosis after LT and establishing a model assessing prognosis are very important to HCC patients. There has recently been a lot of clinical and basic research on recurrence and prognosis after LT. Progress has been made, especially in selection criteria for LT recipients and risk factors for predicting prognosis after LT. Hangzhou criteria, in line with China’s high current incidence rate of primary liver, are first proposed by Chinese scholars of LT, and are accepted world-wide, and make an important contribution to the development of LT.

中文概要

研究肝癌肝移植患者术后生存与影响生存的各影 响因素之间的关系,并评价各影响因素及移植标 准的价值。筛选有效的预测肝癌预后的影响因 素,可帮助建立肝移植术后肿瘤预后预警机制, 对改善肝癌肝移植受体的术后预后具有重要意 义。杭州标准是被国际移植学界广泛接受的肝癌 肝移植标准,在引领肝癌肝移植领域的发展中做 出了重要贡献。

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References

  • Agopian VG, Harlander-Locke M, Zarrinpar A, et al., 2015. A novel prognostic nomogram accurately predicts hepatocellular carcinoma recurrence after liver transplantation: analysis of 865 consecutive liver transplant recipients. J Am Coll Surg, 220(4):416–427. https://doi.org/10.1016/j.jamcollsurg.2014.12.025

    Article  PubMed  Google Scholar 

  • Ahn CS, Moon DB, Lee SG, et al., 2014. Survival differences between Milan criteria after down-staging and De novo Milan in living donor liver transplantation for hepatocellular carcinoma. Hepatogastroenterology, 61(129): 187–191.

    PubMed  Google Scholar 

  • Akoad ME, Pomfret EA, 2015. Surgical resection and liver transplantation for hepatocellular carcinoma. Clin Liver Dis, 19(2):381–399. https://doi.org/10.1016/j.cld.2015.01.007

    Article  PubMed  Google Scholar 

  • Audet M, Panaro F, Piardi T, et al., 2009. Are the Hangzhou criteria adaptable to hepatocellular carcinoma patients for liver transplantation in Western countries? Liver Transpl, 15(7):822–823. https://doi.org/10.1002/lt.21765

    Article  PubMed  Google Scholar 

  • Balogh J, Victor D 3rd, Asham EH, et al., 2016. Hepatocellular carcinoma: a review. J. Hepatocell Carcinoma, 3:41–53. https://doi.org/10.2147/JHC.S61146

    Article  PubMed  PubMed Central  Google Scholar 

  • Chan SC, 2013. Liver transplantation for hepatocellular carcinoma. Liver Cancer, 2(3-4):338–344. https://doi.org/10.1159/000343849

    Article  PubMed  PubMed Central  Google Scholar 

  • Ciccarelli O, Lai Q, Goffette P, et al., 2012. Liver transplantation for hepatocellular cancer: UCL experience in 137 adult cirrhotic recipients. Alpha-foetoprotein level and locoregional treatment as refined selection criteria. Transpl Int, 25(8):867–875. https://doi.org/10.1111/j.1432-2277.2012.01512.x

    PubMed  CAS  Google Scholar 

  • Duvoux C, Roudot-Thoraval F, Decaens T, et al., 2012. Liver transplantation for hepatocellular carcinoma: a model including α-fetoprotein improves the performance of Milan criteria. Gastroenterology, 143(4):986–994.e3. https://doi.org/10.1053/j.gastro.2012.05.052

    Article  PubMed  CAS  Google Scholar 

  • Fan ST, 2008. Selection of HCC patients for liver transplantation: the Milan criteria, Hangzhou criteria and beyond. Hepatobiliary Pancreat Dis Int, 7(3):233–234.

    PubMed  Google Scholar 

  • Ferreira MV, Chaib E, Nascimento MU, et al., 2012. Liver transplantation and expanded Milan criteria: does it really work? Arq Gastroentero, 49(3):189–194. https://doi.org/10.1590/S0004-28032012000300004

    Article  Google Scholar 

  • Grąt M, Kornasiewicz O, Lewandowski Z, et al., 2014. Combination of morphologic criteria and α-fetoprotein in selection of patients with hepatocellular carcinoma for liver transplantation minimizes the problem of posttransplant tumor recurrence. World J Surg, 38(10):2698–2707. https://doi.org/10.1007/s00268-014-2647-3

    Article  PubMed  PubMed Central  Google Scholar 

  • Guerrini GP, Pinelli D, di Benedetto F, et al., 2015. Predictive value of nodule size and differentiation in HCC recurrence after liver transplantation. Surg Oncol, 25(4): 419–428. https://doi.org/10.1016/j.suronc.2015.09.003

    Article  PubMed  Google Scholar 

  • Gugenheim J, Bredt LC, Iannelli A, et al., 2013. Recurrence after liver transplantation for hepatocellular carcinoma according to up-to-seven criteria. Hepatogastroenterology, 60(124):799–806. https://doi.org/10.5754/hge12997

    PubMed  Google Scholar 

  • Guo R, Feng X, Xiao S, et al., 2015. Short- and long-term outcomes of hepatectomy with or without radiofrequencyassist for the treatment of hepatocellular carcinomas: a retrospective comparative cohort study. Biosci Trends, 9(1):65–72. https://doi.org/10.5582/bst.2014.01142

    Article  PubMed  CAS  Google Scholar 

  • Hameed B, Mehta N, Sapisochin G, et al., 2014. Alphafetoprotein gt;1000 ng/ml as an exclusion criterion for liver transplantation in patients with hepatocellular carcinoma meeting Milan criteria. Liver Transpl, 20(8):945–951. https://doi.org/10.1002/lt.23904

    Article  PubMed  PubMed Central  Google Scholar 

  • Hirokawa F, Hayashi M, Miyamoto Y, et al., 2015. Predictors of poor prognosis by recurrence patterns after curative hepatectomy for hepatocellular carcinoma in Child-Pugh classification A. Hepatogastroenterology, 62(137):164–168.

    PubMed  Google Scholar 

  • Ioannou GN, Perkins JD, Carithers RL, 2008. Liver transplantation for hepatocellular carcinoma: impact of the MELD allocation system and predictors of survival. Gastroenterology, 134(5):1342–1351. https://doi.org/10.1053/j.gastro.2008.02.013

    Article  PubMed  Google Scholar 

  • Kanai T, Hirohashi S, Upton MP, et al., 1987. Pathology of small hepatocellular carcinoma. A proposal for a new gross classification. Cancer, 60(4):810–819. https://doi.org/10.1002/1097-0142(19870815)60:4lt;810:: AID-CNCR2820600417gt;3.0.CO;2-1

    PubMed  CAS  Google Scholar 

  • Kashkoush S, El Moghazy W, Kawahara T, et al., 2014. Three-dimensional tumor volume and serum alphafetoprotein are predictors of hepatocellular carcinoma recurrence after liver transplantation: refined selection criteria. Clin Transplant, 28(6):728–736. https://doi.org/10.1111/ctr.12373

    Article  PubMed  CAS  Google Scholar 

  • Kim H, Park MS, Park YN, et al., 2009. Preoperative radiologic and postoperative pathologic risk factors for early intra-hepatic recurrence in hepatocellular carcinoma patients who underwent curative resection. Yonsei Med J, 50(6):789–795.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim JH, Sinn DH, Gwak GY, et al., 2016. Factors determining long-term outcomes of hepatocellular carcinoma within the Milan criteria: liver transplantation versus locoregional therapy: a retrospective cohort study. Medicine (Baltimore), 95(35):e4735. https://doi.org/10.1097/MD.0000000000004735

    Article  CAS  Google Scholar 

  • Kumaran V, 2014. Role of liver transplantation for hepatocellular carcinoma. J Clin Exp Hepatol, 4(Suppl 3):S97–S103. https://doi.org/10.1016/j.jceh.2014.01.002

    Article  PubMed  PubMed Central  Google Scholar 

  • Kwon CH, Kim DJ, Han YS, et al., 2007. HCC in living donor liver transplantation: can we expand the Milan criteria? Dig Dis, 25(4):313–319. https://doi.org/10.1159/000106911

    Article  PubMed  Google Scholar 

  • Lai Q, Avolio AW, Manzia TM, et al., 2011. Role of alphafetoprotein in selection of recipients with hepatocellular carcinoma waiting for liver transplantation: must we reconsider it? Int J Biol Markers, 26(3):153–159. https://doi.org/10.5301/JBM.2011.8557

    Article  PubMed  CAS  Google Scholar 

  • Lai Q, Avolio AW, Manzia TM, et al., 2012. Combination of biological and morphological parameters for the selection of recipients with hepatocellular carcinoma waiting for liver transplantation. Clin Transplant, 26(2):E125–E131. https://doi.org/10.1111/j.1399-0012.2011.01572.x

    Article  PubMed  Google Scholar 

  • Lee KW, Yi NJ, Suh KS, 2014. Section 5. Further expanding the criteria for HCC in living donor liver transplantation: when not to transplant: SNUH experience. Transplantation, 97(Suppl 8):S20–S23. https://doi.org/10.1097/01.tp.0000446269.20934.d3

    Article  PubMed  Google Scholar 

  • Lei JY, Wang WT, Yan LN, 2013. Up-to-seven criteria for hepatocellular carcinoma liver transplantation: a single center analysis. World J Gastroenterol, 19(36):6077–6083. https://doi.org/10.3748/wjg.v19.i36.6077

    Article  PubMed  PubMed Central  Google Scholar 

  • Li Z, Zhao X, Jiang P, et al., 2016. HBV is a risk factor for poor patient prognosis after curative resection of hepatocellular carcinoma: a retrospective case-control study. Medicine (Baltimore), 95(31):e4224. https://doi.org/10.1097/MD.0000000000004224

    Article  Google Scholar 

  • Mazzaferro V, Regalia E, Doci R, et al., 1996. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med, 334(11): 693–699. https://doi.org/10.1056/NEJM199603143341104

    Article  PubMed  CAS  Google Scholar 

  • Mazzaferro V, Llovet JM, Miceli R, et al., 2009. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. Lancet Oncol, 10(1):35–43. https://doi.org/10.1016/S1470-2045(08)70284-5

    Article  PubMed  Google Scholar 

  • McHugh PP, Gilbert J, Vera S, et al., 2010. Alpha-fetoprotein and tumor size are associated with microvascular invasion in explanted livers of patients undergoing transplantation with hepatocellular carcinoma. HPB (Oxford), 12(1):56–61. https://doi.org/10.1111/j.1477-2574.2009.00128.x

    Article  Google Scholar 

  • Merli M, Nicolini G, Gentili F, et al., 2005. Predictive factors of outcome after liver transplantation in patients with cirrhosis and hepatocellular carcinoma. Transpl Proc, 37(6):2535–2540. https://doi.org/10.1016/j.transproceed.2005.06.031

    Article  CAS  Google Scholar 

  • Molmenti PE, Marsh WJ, Dvorchik I, et al., 1999. Hepatobiliary malignancies: primary hepatic malignant neoplasms. Surg Clin North Am, 79(1):43–57. https://doi.org/10.1016/S0039-6109(05)70006-2

    Article  PubMed  CAS  Google Scholar 

  • Müller V, Fortsch T, Gündelm M, et al., 2013. Long-term outcome of liver transplantation as treatment modality in patients with hepatocellular carcinoma in cirrhosis: a single-center experience. Transplant Proc, 45(5):1957–1960. https://doi.org/10.1016/j.transproceed.2013.01.035

    Article  PubMed  Google Scholar 

  • Patel MS, Kohn R, Kratz JR, et al., 2015. The race to liver transplantation: a comparison of patients with and without hepatocellular carcinoma from listing to post transplantation. J Am Coll Surg, 220(6):1001–1007. https://doi.org/10.1016/j.jamcollsurg.2014.12.050

    Article  PubMed  Google Scholar 

  • Pawlik TM, Delman KA, Vauthey JN, et al., 2005. Tumor size predicts vascular invasion and histologic grade: implications for selection of surgical treatment for hepatocellular carcinoma. Liver Transpl, 11(9):1086–1092. https://doi.org/10.1002/lt.20472

    Article  PubMed  Google Scholar 

  • Reddy SS, Civan JM, 2016. From Child-Pugh to model for end-stage liver disease: deciding who needs a liver transplant. Med Clin North Am, 100(3):449–464. https://doi.org/10.1016/j.mcna.2015.12.002

    Article  PubMed  Google Scholar 

  • Silva MF, Sapisochin G, Strasser SI, et al., 2013. Liver resection and transplantation offer similar 5-year survival for Child-Pugh-Turcotte A HCC-patients with a single nodule up to 5 cm: a multicenter, exploratory analysis. Eur J Surg Oncol, 39(4):386–395. https://doi.org/10.1016/j.ejso.2012.12.011

    Article  PubMed  CAS  Google Scholar 

  • Sohn W, Paik YH, Kim JM, et al., 2014. HBV DNA and HBsAg levels as risk predictors of early and late recurrence after curative resection of HBV-related hepatocellular carcinoma. Ann Surg Oncol, 21(7):2429–2435. https://doi.org/10.1245/s10434-014-3621-x

    Article  PubMed  Google Scholar 

  • Toso C, Asthana S, Bigam DL, et al., 2009. Reassessing selection criteria prior to liver transplantation for hepatocellular carcinoma utilizing the scientific registry of transplant recipients database. Hepatology, 49(3):832–838. https://doi.org/10.1002/hep.22693

    Article  PubMed  Google Scholar 

  • Varona MA, Soriano A, Aguirre-Jaime A, et al., 2015. Risk factors of hepatocellular carcinoma recurrence after liver transplantation: accuracy of the alpha-fetoprotein model in a single-center experience. Transplant Proc, 47(1): 84–89. https://doi.org/10.1016/j.transproceed.2014.12.013

    Article  PubMed  CAS  Google Scholar 

  • WHO (World Health Organization), 2016. Hepatitis B. http://www.who.int/mediacentre/factsheets/fs204/en [Accessed on Jan. 28, 2017].

    Google Scholar 

  • Wong LL, Naugler WE, Schwartz J, et al., 2013. Impact of locoregional therapy and alpha-fetoprotein on outcomes in transplantation for liver cancer: a UNOS Region 6 pooled analysis. Clin Transplant, 27(1):E72–E79. https://doi.org/10.1111/ctr.12056

    Article  PubMed  Google Scholar 

  • Xu X, Ke QH, Shao ZX, et al., 2009. The value of serum α-fetoprotein in predicting tumor recurrence after liver transplantation for hepatocellular carcinoma. Dig Dis Sci, 54(2):385–388. https://doi.org/10.1007/s10620-008-0349-0

    Article  PubMed  CAS  Google Scholar 

  • Xu X, Lu D, Ling Q, et al., 2016. Liver transplantation for hepatocellular carcinoma beyond the Milan criteria. Gut, 65(6):1035–1041. https://doi.org/10.1136/gutjnl-2014-308513

    Article  PubMed  CAS  Google Scholar 

  • Yang SH, Suh KS, Lee HW, et al., 2007. A revised scoring system utilizing serum alphafetoprotein levels to expand candidates for living donor transplantation in hepatocellular carcinoma. Surgery, 141(5):598–609. https://doi.org/10.1016/j.surg.2006.11.006

    Article  PubMed  Google Scholar 

  • Yao FY, Ferrell L, Bass NM, et al., 2001. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology, 33(6):1394–1403. https://doi.org/10.1053/jhep.2001.24563

    Article  PubMed  CAS  Google Scholar 

  • Yao FY, Xiao L, Bass NM, et al., 2007. Liver transplantation for hepatocellular carcinoma: validation of the UCSF expanded criteria based on preoperative imaging. Am J Transplant, 7(11):2587–2596. https://doi.org/10.1111/j.1600-6143.2007.0965.x

    Article  PubMed  CAS  Google Scholar 

  • Yao FY, Mehtam N, Flemming J, et al., 2015. Downstaging of hepatocellular cancer before liver transplant: long-term outcome compared to tumors within Milan criteria. Hepatology, 61(6):1968–1977. https://doi.org/10.1002/hep.27752

    Article  PubMed  PubMed Central  Google Scholar 

  • Zavaglia C, de Carlis L, Alberti AB, et al., 2005. Predictor of longterm survival after liver transplant at ion for hepatocellular carcinoma. Am J Gastroenterol, 100(12):2708–2716. https://doi.org/10.1111/j.1572-0241.2005.00289.x

    Article  PubMed  Google Scholar 

  • Zhang Q, Shang L, Zang Y, et al., 2014. α-Fetoprotein is a potential survival predictor in hepatocellular carcinoma patients with hepatitis B selected for liver transplantation. Eur J Gastroenterol Hepatol, 26(5):544–552. https://doi.org/10.1097/MEG.0000000000000029

    Article  PubMed  CAS  Google Scholar 

  • Zheng SS, Xu X, Wu J, et al., 2008. Liver transplantation for hepatocellular carcinoma: Hangzhou experiences. Transplantation, 85(12):1726–1732. https://doi.org/10.1097/TP.0b013e31816b67e4

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Ultrasound, Shaoxing Second Hospital, Shaoxing, 312000, China

    Li-ying Wang

  2. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Health, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China

    Shu-sen Zheng

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  1. Li-ying Wang
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  2. Shu-sen Zheng
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Correspondence to Li-ying Wang.

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Project supported by the National Natural Science Foundation of China (No. 81121002) and the National S&T Major Project of China (No. 2012ZX10002017)

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Wang, Ly., Zheng, Ss. Advances in predicting the prognosis of hepatocellular carcinoma recipients after liver transplantation. J. Zhejiang Univ. Sci. B 19, 497–504 (2018). https://doi.org/10.1631/jzus.B1700156

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