Skip to main content
Log in

Immunological effects of a 10-μg dose of domestic hepatitis B vaccine in adults

  • Communication
  • Published:
Journal of Zhejiang University SCIENCE B Aims and scope Submit manuscript

Abstract

Objective

To evaluate the immunological effects of three types of domestic 10-μg/dose hepatitis B vaccines in adults compared with a foreign vaccine, and to provide scientific evidence in support of adult hepatitis B vaccination.

Methods

Adults from five counties (Deqing, Changxing, Nanxun, Wuxing, Anji) in Huzhou City, Shaoxing County and Tongxiang County, Zhejiang Province, China were selected. Blood samples were taken to assess serum HBsAg, anti-HBs, and anti-HBc using a chemiluminescence immunoassay. Adults, aged 16 to 49 years and who were anti-HBs negative at baseline, received hepatitis B immunizations at 0, 1, and 6 months. Anti-HBs levels were assessed one month after the third and final vaccination.

Results

A total of 1 872 adults were immunized and the average positive rate was 89.5%. Four types of hepatitis B vaccine were used, including three from Chinese companies (Shenzhen Kangtai, Dalian High-Tech, and North China Pharmaceutical) and one from a UK company (GlaxoSmithKline). Their seroconversion rates were 81.67%, 95.05%, 89.64%, and 86.81%, respectively. There was a significant difference between the anti-HBs positive conversion rates of the four types (P<0.005) but the seroconversion rates among the different vaccines were not significantly different (χ 2=2.123, P=0.145). The average anti-HBs geometric mean titers (GMTs) of non-immune adults immunized with each of the four vaccines were 177.28, 473.23, 246.13, and 332.20 mIU/ml, respectively. There were no statistically significant differences in the GMTs between the three types of domestic vaccine and the foreign vaccine (t=−1.575, P=0.116).

Conclusions

Domestic recombinant hepatitis B vaccines can achieve immunization effects comparable to those of a foreign vaccine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Bonanni, P., 1995. Implementation in Italy of a universal vaccination programme against hepatitis B. Vaccine, 13(s1):68–71. [doi:10.1016/0264-410X(95)80058-L]

    Google Scholar 

  • Bryan, J.P., Craig, P.G., Reyes, L., Hakre, S., Jaramillo, R., Harlan, H., MacArthy, P., Legters, L.J., 1995. Randomized comparison of 5 and 10 microgram doses of two recombinant hepatitis B vaccines. Vaccine, 13(11): 978–982. [doi:10.1016/0264-410X(95)00030-5]

    Article  PubMed  CAS  Google Scholar 

  • Chang, M.H., Hadzic, D., Rouassant, S.H., Jonas, M., Kohn, I.J., Negro, F., Roberts, E., Sibal, A., 2004. Acute and chronic hepatitis: Working Group Report of the Second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J. Pediatr. Gastroenterol. Nutr., 39(s2):584–588. [doi:10.1097/00005176-200406002-00002]

    Article  Google Scholar 

  • Coates, T., Wilson, R., Patrick, G., Andre, F., Watson, V., 2001. Hepatitis B vaccines: assessment of the seroprotective efficacy of two recombinant DNA vaccines. Clin. Ther., 23(3):392–403. [doi:10.1016/S0149-2918(01)80044-8]

    Article  PubMed  CAS  Google Scholar 

  • Daniels, D., Grytdal, S., Wasley, A., 2009. Surveillance for acute viral hepatitis—United States, 2007. MMWR Surveill. Summ., 58(3):1–27.

    PubMed  Google Scholar 

  • Dong, M.H., Lin, Y.D., Qian, Y.H., Jiang, Y., Deng, Y., Ding, S., Ren, Y.J., 2009. Immunity effect of homemade recombinant yeast-derived hepatitis B vaccine in adults. Mod. Med. J. China, 11(2):24–26.

    Google Scholar 

  • Ganczak, M., Szych, Z., Korzen, M., 2009. Preoperative vaccination for HBV at Polish hospitals as a possible public health tool to limit the spread of the epidemic: a cross-sectional study. Vaccine, 27(30):3969–3974. [doi:10.1016/j.vaccine.2009.04.042]

    Article  PubMed  Google Scholar 

  • Ganem, D., Prince, A.M., 2004. Hepatitis B virus infection—natural history and clinical consequences. N. Engl. J. Med., 350(11):1118–1129. [doi:10.1056/NEJMra031087]

    Article  PubMed  CAS  Google Scholar 

  • Gilbert, C.L., Klopfer, S.O., Martin, J.C., Schodel, F.P., Bhuyan, P.K., 2011. Safety and immunogenicity of a modified process hepatitis B vaccine in healthy adults ≥50 years. Hum. Vaccin, 7(12):1336–1342. [doi:10. 4161/hv.7.12.18333]

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, S.T., Zhou, F., Hadler, S.C., Bell, B.P., Mast, E.E., Margolis, H.S., 2005. A mathematical model to estimate global hepatitis B disease burden and vaccination impact. Int. J. Epidemiol., 34(6):1329–1339. [doi:10.1093/ije/dyi206]

    Article  PubMed  Google Scholar 

  • Gong, X.Y., Zhong, J.Y., 2009. Evaluation of Immunogenicity of 10 μg Recombinant yeast-derived hepatitis B vaccine in adults. China Prevent Med., 10(10):934–936 (in Chinese).

    Google Scholar 

  • Jilg, W., Schmidt, M., Deinhardt, F., 1988. Persistence of specific antibodies after hepatitis B vaccination. J. Hepatol., 6(2):201–207. [doi:10.1016/S0168-8278(88)80032-1]

    Article  PubMed  CAS  Google Scholar 

  • Lavanchy, D., 2004. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J. Viral Hepat., 11(2):97–107. [doi:10.1046/j.1365-2893.2003.00487.x]

    Article  PubMed  CAS  Google Scholar 

  • Liang, X., Bi, S., Yang, W., Wang, L., Cui, G., Cui, F., Zhang, Y., Liu, J., Gong, X., Chen, Y., et al., 2009a. Epidemiological serosurvey of hepatitis B in China— declining HBV prevalence due to hepatitis B vaccination. Vaccine, 27(47):6550–6557. [doi:10.1016/j.vaccine.2009.08.048]

    Article  PubMed  Google Scholar 

  • Liang, X., Bi, S., Yang, W., Wang, L., Cui, G., Cui, F., Zhang, Y., Liu, J., Gong, X., Chen, Y., et al., 2009b. Evaluation of the impact of hepatitis B vaccination among children born during 1992–2005 in China. J. Infect. Dis., 200(1): 39–47. [doi:10.1086/599332]

    Article  PubMed  Google Scholar 

  • Lu, F.M., Zhuang, H., 2009. Management of hepatitis B in China. Chin. Med. J. (Engl.), 122(1):3–4.

    Google Scholar 

  • Mast, E.E., Mahoney, F.J., Alter, M.J., Margolis, H.S., 1998. Progress toward elimination of hepatitis B virus transmission in the United States. Vaccine, 16(Suppl.): 48–51. [doi:10.1016/S0264-410X(98)00294-1]

    Article  Google Scholar 

  • Mast, E.E., Weinbaum, C.M., Fiore, A.E., Alter, M.J., Bell, B.P., Finelli, L., Rodewald, L.E., Douglas, J.M.Jr., Janssen, R.S., Ward, J.W., 2006. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP). Part II: immunization of adults. MMWR Recomm. Rep., 55(RR-16):1–33, quiz CE31–CE34.

    PubMed  Google Scholar 

  • Rendi-Wagner, P., Kundi, M., Stemberger, H., Wiedermann, G., Holzmann, H., Hofer, M., Wiesinger, K., Kollaritsch, H., 2001. Antibody-response to three recombinant hepatitis B vaccines: comparative evaluation of multicenter travel-clinic based experience. Vaccine, 19(15–16): 2055–2060. [doi:10.1016/S0264-410X(00)00410-2]

    Article  PubMed  CAS  Google Scholar 

  • Shen, L.Z., Yao, J., 2011. Study development on booster immune strategy of hepatitis B vaccine. Zhejiang J. Prevent. Med., 23(12):22–25 (in Chinese).

    Google Scholar 

  • Trivello, R., Chiaramonte, M., Ngatchu, T., Baldo, V., Majori, S., Moschen, M.E., Simoncello, I., Renzulli, G., Naccarato, R., 1995. Persistence of anti-HBs antibodies in health care personnel vaccinated with plasma-derived hepatitis B vaccine and response to recombinant DNA HB booster vaccine. Vaccine, 13(2):139–141. [doi:10.1016/0264-410X(95)93126-T]

    Article  PubMed  CAS  Google Scholar 

  • Weinbaum, C.M., Williams, I., Mast, E.E., Wang, S.A., Finelli, L., Wasley, A., Neitzel, S.M., Ward, J.W., 2008. Recommendations for identification and public health management of persons with chronic hepatitis B virus infection. MMWR Recomm. Rep., 57(RR-8):1–20.

    PubMed  Google Scholar 

  • WHO (World Health Organization), 2000. Hepatitis B. WHO, Geneva, Switzerland. Available from http://www.who.int/mediacentre/factsheets/fs204/en [Accessed on 2 June 2010].

    Google Scholar 

  • Yao, J., Chen, Y.D., 2009. Immunity effect of domestic hepatitis B vaccine in adults. China Prevent Med., 10(4): 258–261 (in Chinese).

    Google Scholar 

  • Yao, J., Ren, J.J., Shen, L.Z., Chen, Y.D., Liang, X.F., Cui, F.Q., Li, Q., Jiang, Z.G., Wang, F.Z., 2011. The effects of booster vaccination of hepatitis B vaccine on anti-HBV surface antigen negative children 11–15 years after primary vaccination. Hum. Vaccin., 7(10):1055–1059. [doi:10.4161/hv.7.10.15990]

    Article  PubMed  CAS  Google Scholar 

  • Young, M.D., Gooch, W.M.3rd, Zuckerman, A.J., Du, W., Dickson, B., Maddrey, W.C., 2001. Comparison of a triple antigen and a single antigen recombinant vaccine for adult hepatitis B vaccination. J. Med. Virol., 64(3): 290–298. [doi:10.1002/jmv.1049]

    Article  PubMed  CAS  Google Scholar 

  • Yuan, Y.B., Zheng, X.H., Wang, Z.Q., 2003. Study on the immuno-effects and security of Chinese Hamster Ovary (CHO) cell hepatitis B vaccine among adults, under different dosages. Chin. J. Infect. Dis., 21(6):423–424 (in Chinese).

    Google Scholar 

  • Zhang, W., Lin, C., Han, L., Li, L., Gao, P., Lin, H., Gong, X., Huang, F., Tang, Y., Ma, J., 2010. Study on the immuno-effects and influencing factors of Chinese Hamster Ovary (CHO) cell hepatitis B vaccine among adults, under different dosages. Chin. J. Epidemiol., 31(7): 767 (in Chinese).

    CAS  Google Scholar 

  • Zuckerman, J., Langer, B., 2005. Hepatitis B vaccination in a school age population: a feasibility study. J. Med. Virol., 76(1):47–54. [doi:10.1002/jmv.20335]

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Jun Yao or Lan-juan Li.

Additional information

Project (No. 2009ZX10004-901) supported by the National Scientific and Technological Major Project of China

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ren, Jj., Dai, Xw., Jiang, Zg. et al. Immunological effects of a 10-μg dose of domestic hepatitis B vaccine in adults. J. Zhejiang Univ. Sci. B 13, 948–954 (2012). https://doi.org/10.1631/jzus.B1200179

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1631/jzus.B1200179

Key words

CLC number

Navigation