Malignant peritoneal mesothelioma presenting with persistent high fever

  • Li-ying Chen
  • Ling-xiu Huang
  • Jin Wang
  • Yi Qian
  • Li-zheng Fang
Case Report


Malignant peritoneal mesothelioma (MPM) is a rare tumor that develops in the peritoneum. In this paper, we describe an extremely rare case of MPM metastasizing to the appendix in a 48-year-old female who initially presented with a persistent high fever. The woman reported a slight lower abdominal discomfort which had been relieved by urination for four months. She had lost 5 kg of weight. There was no nausea, vomiting, diarrhea, abdominal pain, or abdominal distension. Many broad spectrum antibiotics were given without relief of fever. Computed tomography (CT) scans revealed a thickened omentum majus and diffused multiple omental nodules. An omentectomy, appendectomy, and adnexectomy were carried out. A gross pathologic specimen of omentum tissue revealed a firm gray-white mass. Microscopic and immunohistochemical examinations confirmed the diagnosis of appendiceal and bilateral adnexal metastases of an MPM. These results suggest that MPM should be considered in the differential diagnosis of unexplained persistent high fever. Awareness of such atypical presentations of mesothelioma may help to make a correct diagnosis.

Key words

Malignant peritoneal mesothelioma High fever Metastasis 

CLC number



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Copyright information

© Zhejiang University and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Li-ying Chen
    • 1
  • Ling-xiu Huang
    • 1
  • Jin Wang
    • 2
  • Yi Qian
    • 1
  • Li-zheng Fang
    • 1
  1. 1.Department of Family Medicine, Sir Run Run Shaw Hospital, School of MedicineZhejiang UniversityHangzhouChina
  2. 2.Department of Pathology, Sir Run Run Shaw Hospital, School of MedicineZhejiang UniversityHangzhouChina

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