Journal of Zhejiang University SCIENCE B

, Volume 12, Issue 6, pp 428–435 | Cite as

HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations

  • Li Shi
  • Xiao-qin Huang
  • Lei Shi
  • Yu-fen Tao
  • Yu-feng Yao
  • Liang Yu
  • Ke-qin Lin
  • Wen Yi
  • Hao Sun
  • Katsushi Tokunaga
  • Jia-you Chu
Article

Abstract

A study of the human leukocyte antigen (HLA) genetic characteristics in the Zhuang, the largest ethnic population in China, would provide insight into Zhuang history and give a useful tool for disease associations, transplantation, and anthropology. In the present study, we report the comprehensive HLA-A, HLA-B, HLA-C, and HLA-DRB1 alleles and haplotypes in the Zhuang population of southern China for the first time. A total of 13 HLA-A, 24 HLA-B, 22 HLA-C, and 18 HLA-DRB1 were identified in 104 Zhuang individuals. The frequencies of HLA-A*11:01, A*02:07, A*24:02, A*02:03, and A*33:03 on A loci, B*15:02, B*58:01, B*46:01, and B*13:01 on B loci, C*03:04, C*08:01, C*01:02, C*03:02, and C*07:02 on C loci, and DRB1*15:01, DRB1*16:02, DRB1*14:01, DRB1*15:02, and DRB1*03:01 on the DRB1 loci were S>10%. The A*33:03-C*03:02-B*58:01-DRB1*03:01 and A*02:07-C*01:02-B*46:01-DRB1*14:01 haplotypes were predominant in the Zhuang. The phylogenetic tree, as well as the analysis of haplotypes, suggested that the Zhuang are genetically similar to southern Chinese populations, especially the Zhuang-Dong language-speaking populations, such as the Bouyei, Dai, and Maonan. Even though the Zhuang and southern Chinese populations shared common alleles and haplotypes, the Zhuang has maintained its unique genetic characteristics.

Key words

Human leukocyte antigen (HLA) alleles Haplotypes Zhuang population 

CLC number

Q987 

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Copyright information

© Zhejiang University and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Li Shi
    • 1
  • Xiao-qin Huang
    • 1
  • Lei Shi
    • 1
  • Yu-fen Tao
    • 1
  • Yu-feng Yao
    • 1
  • Liang Yu
    • 1
  • Ke-qin Lin
    • 1
  • Wen Yi
    • 1
  • Hao Sun
    • 1
  • Katsushi Tokunaga
    • 2
  • Jia-you Chu
    • 1
  1. 1.Institute of Medical BiologyChinese Academy of Medical Sciences & Peking Union Medical CollegeKunmingChina
  2. 2.Department of Human Genetics, Graduate School of MedicineUniversity of TokyoTokyoJapan

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